SorLA Antibody

Images

 
Western Blot: SorLA Antibody [NB100-785] - (0.3ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SorLA Antibody Summary

Immunogen
Peptide with sequence C-TGFSDDVPMVIA corresponding to C-Terminus according to NP_003096.1.
Epitope
The epitope region is located at the C-terminal end of SORL1.
Localization
Type I membrane protein
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SORL1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.3 - 1 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 250 kDa band observed in mouse and rat brain lysates (calculated MW of 248 kDa band according to human NP_003096.1, and 247 kDa band accordnig to mouse NP_035566.2).
Positive Control
Lung Lysate (NB820-59235)
Publications
Read Publication using NB100-785.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human, Rat, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SorLA Antibody

  • C11orf32
  • chromosome 11 open reading frame 32
  • FLJ21930
  • FLJ39258
  • gp250
  • Low-density lipoprotein receptor relative with 11 ligand-binding repeats
  • LR11
  • LR11LDLR relative with 11 ligand-binding repeats
  • LRP9
  • mosaic protein LR11
  • SORL1
  • SorLA
  • SorLA-1SORLA
  • sortilin-related receptor
  • sortilin-related receptor, L(DLR class) A repeats containing
  • sortilin-related receptor, L(DLR class) A repeats-containing
  • Sorting protein-related receptor containing LDLR class A repeats

Background

SORL1 is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. It binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. SORL1 binds the receptor-associated protein (RAP). It could play a role in cell-cell interaction. SORL1 is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. It is also found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. Moreover, it is expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SorLA Antibody (NB100-785)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SORL1
Entrez
Uniprot