Somatostatin R3/SSTR3 Antibody

Immunohistochemistry-Paraffin: Somatostatin R3/SSTR3 Antibody [NB100-74538] - Staining of SSTR3 in human pancreatic islands.

• Reactivity: Hu
• Applications: WB, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Somatostatin R3/SSTR3 Antibody Summary

• Description: Novus Biologicals Rabbit Somatostatin R3/SSTR3 Antibody (NB100-74538) is a polyclonal antibody validated for use in IHC, WB and ICC/IF. Anti-Somatostatin R3/SSTR3 Antibody: Cited in 2 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.
• Specificity: Somatostatin Receptor 3
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SSTR3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:5000
  • Immunohistochemistry 1:2500
  • Immunohistochemistry-Paraffin 1:2500
  • Western Blot 1:5000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Whole serum
• Preservative: 0.05% Sodium Azide
• Purity: Unpurified

Alternate Names for Somatostatin R3/SSTR3 Antibody

• Somatostatin R3
• somatostatin receptor 3
• SomatostatinR3
• SS-3-R
• SS3-R
• SSR-28
• SST3
• SSTR3

Background

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Somatostatin R3/SSTR3 Antibody (NB100-74538)(2)

Publications using NB100-74538

• Tollefsen SE, Jarmund AH, Ytterhus B et al. Somatostatin Receptors in Human Meningiomas-Clinicopathological Aspects Cancers (Basel) 2021-11-15 [PMID: 34830858] (Immunohistochemistry, Human)
• Arne G, Nilsson B, Dalmo J et al. Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs Acta Oncol 2012-11-01 [PMID: 23116418] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: SSTR3
• Entrez:
  • 6753(Human)
• Uniprot:
  • P32745()