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Somatostatin R3/SSTR3 Antibody

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Immunohistochemistry-Paraffin: Somatostatin R3/SSTR3 Antibody [NB100-74538] - Staining of SSTR3 in human pancreatic islands.
Immunohistochemistry-Paraffin: Somatostatin R3/SSTR3 Antibody [NB100-74538] - Staining of SSTR3 in human pancreatic islands.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Somatostatin R3/SSTR3 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.
Specificity
Somatostatin Receptor 3
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SSTR3
Purity
Unpurified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:5000
  • Immunohistochemistry 1:2500
  • Immunohistochemistry-Paraffin 1:2500
  • Western Blot 1:5000
Publications
Read Publication using
NB100-74538 in the following applications:

  • IHC
    1 publication

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Whole serum
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for Somatostatin R3/SSTR3 Antibody

  • Somatostatin R3
  • somatostatin receptor 3
  • SomatostatinR3
  • SS-3-R
  • SS3-R
  • SSR-28
  • SST3
  • SSTR3

Background

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Immunocytochemistry/Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of Somatostatin Receptor 4 (green) showing staining in the cytoplasm of SH-SY5Y cells (right) compared to a negative control without primary antibody (left).
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Immunocytochemistry/Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of Somatostatin Receptor 4 (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative control without primary antibody (left).
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Somatostatin
R3/SSTR3 Antibody
NB100-74538
Somatostatin R3/SSTR3 Antibody
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P

Publications for Somatostatin R3/SSTR3 Antibody (NB100-74538)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC.


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Bioinformatics

Gene Symbol SSTR3
Entrez
Uniprot