SOCS-5 Antibody [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 405

SOCS-5 Antibody [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human SOCS-5
  Met1-Lys536
  Accession # O75159
• Specificity: Detects human SOCS-5 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human SOCS‑1, -2, -3, -6, and -7 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOCS-5 Antibody [Alexa Fluor® 405]

• CIS6
• CIS6Cytokine-inducible SH2 protein 6
• CISH5
• CISH6
• CISH6CIS-6
• KIAA0671Cytokine-inducible SH2-containing protein 5
• SOCS5
• SOCS-5
• SOCS-5CISH5
• suppressor of cytokine signaling 5

Background

SOCS-5 (Suppressor of cytokine signaling 5; also CIS-6) is a 55‑60 kDa member of the SOCS family of proteins. It is an SH2-domain containing cytoplasmic adaptor protein expressed by Th1 cells that is known to reduce the expression of the EGF receptor and block signaling by the IL-4 R alpha chain. Human SOCS-5 is 536 amino acids (aa) in length. It contains one SH2 domain (aa 381‑476) and a SOCS box (aa 471‑520) that mediates interaction with E3 ubiquitin ligase complexes. Full-length SOCS-5 is 94% aa identical to mouse SOCS-5.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.