SMURF1 Antibody (530131) [Alexa Fluor® 647]

• Applications: WB
• Clone: 530131
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

SMURF1 Antibody (530131) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human SMURF1
  Met496-Glu757
  Accession # Q9HCE7
• Specificity: Detects human SMURF1 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Smurf-1 is a 757 amino acids E3 ubiquitin-protein ligase encoded by the SMURF1 gene. Smurf-1 ubiquitinates receptor regulated SMAD proteins acting as a negative regulator of BMP signaling pathway, and it has been shown to inhibit osteoblast differentiation by targeting Runx2, the master regulator of osteoblast differentiation, for degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.