SMPD3/NSMase2 Antibody

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Western Blot: NSMASE2 Antibody [NBP1-69344] - This Anti-SMPD3 antibody was used in Western Blot of Fetal Lung tissue lysate at a concentration of 1ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

SMPD3/NSMase2 Antibody Summary

Immunogen
Synthetic peptides corresponding to SMPD3(sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)) The peptide sequence was selected from the middle region of SMPD3 (NP_061137). Peptide sequence RPPEADDPVPGGQARNGAGGGPRGQTPNHN
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SMPD3
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.2-1 ug/ml
Theoretical MW
71 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS and 2% Sucrose
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Notes

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for SMPD3/NSMase2 Antibody

  • EC 3.1.4.12
  • FLJ22593
  • MGC138443
  • Neutral sphingomyelinase 2
  • Neutral sphingomyelinase II
  • NSMASE2
  • nSMase-2
  • SMPD3
  • sphingomyelin phosphodiesterase 3
  • sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinaseII)

Background

SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. SMPD3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SMPD3
Entrez
Uniprot