SMC6L1 Antibody

Product Discontinued

SMC6L1 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 1050 and the C-terminus (residue 1091) of human Structural Maintenance of Chromosomes 6 using the numbering given in TrEMBL entry Q96SB8 (GeneID 79677).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SMC6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:500-1:2000
  • Immunoprecipitation 5-10 ug/mg
  • Western Blot 1:500-1:2500
• Application Notes: Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
• Control:

  SMC6L1 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for SMC6L1 Antibody

• FLJ22116
• hSMC6
• SMC protein 6
• SMC6 structural maintenance of chromosomes 6-like 1 (yeast)
• SMC6 structural maintenance of chromosomes 6-like 1
• SMC-6
• SMC6L1FLJ35534
• structural maintenance of chromosomes 6
• structural maintenance of chromosomes protein 6

Background

SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SMC6
• Entrez:
  • 79677(Human)
  • 67241(Mouse)
• Uniprot:
  • Q96SB8(Human)