SmarcAL1 Antibody (PCRP-SMARCAL1-1C4) [CoraFluor™ 1]

• Reactivity: Hu
• Applications: IHC
• Clone: PCRP-SMARCAL1-1C4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: CoraFluor 1

SmarcAL1 Antibody (PCRP-SMARCAL1-1C4) [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(TM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
  
  CoraFluor(TM) 1, amine reactive
  
  CoraFluor(TM) 1, thiol reactive
  
  For more information, please see our CoraFluor(TM) TR-FRET technology flyer.
• Immunogen: Recombinant full-length human SmarcAL1 protein
• Localization: Nucleus.
• Isotype: IgG2c Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: SMARCAL1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for SmarcAL1 Antibody (PCRP-SMARCAL1-1C4) [CoraFluor™ 1]

• ATP-driven annealing helicase
• EC 3.6.1
• EC 3.6.4.-
• HARPSWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A-like protein 1
• HepA-related protein
• HHARP
• SIOD
• SMARCA-like protein 1
• subfamily a-like 1
• Sucrose nonfermenting protein 2-like 1
• SWI/SNF related, matrix associated, actin dependent regulator of chromatin

Background

SmarcAL1 is encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SMARCAL1