SIRP gamma/CD172g Antibody (595337) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clone: 595337
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

SIRP gamma/CD172g Antibody (595337) [Alexa Fluor® 700] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human SIRPγ/CD172g
  Val64-Ser364
  Accession # Q9P1W8
• Specificity: Detects human SIRP gamma /CD172g in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 20% cross-reactivity with recombinant human (rh) SIRP alpha and rhSIRP beta 1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SIRP gamma/CD172g Antibody (595337) [Alexa Fluor® 700]

• bA77C3.1
• CD172g antigen
• CD172g
• FLJ42230
• signal-regulatory protein beta 2
• Signal-regulatory protein beta-2
• signal-regulatory protein gamma
• SIRP beta 2
• SIRP gamma
• SIRP-B2
• SIRPB2CD172 antigen-like family member B
• SIRP-beta-2
• SIRPG
• SIRPgamma
• SIRP-gamma

Background

Signal-regulatory protein gamma/beta 2 (SIRP gamma/beta 2) is a 45-47 kDa type 1 transmembrane glycoprotein and member of the immunoglobulin superfamily and SIRP family of proteins. Human SIRP gamma/beta 2 is synthesized as a 387 amino acid (aa) precursor that contains a 28 aa signal sequence, a 332 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 4 aa cytoplasmic tail. The ECD contains two Ig-like C1-type domains, one Ig-like V-type domain, and four potential sites for N-linked glycosylation. There are four named isoforms for human SIRP gamma/beta 2. Human SIRP gamma/beta 2 has no orthologs, but it is 75% aa identical to SIRP beta . It is expressed in the liver and at very low levels in brain, heart, lung, pancreas, kidney, placenta, and skeletal muscle. SIRP gamma/beta 2 is also expressed on CD4⁺ T-cells, CD8⁺ T-cells, and activated NK cells. 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.