SHB Antibody [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Janelia Fluor 646

SHB Antibody [Janelia Fluor® 646] Summary

• Immunogen: E. coli-derived recombinant human SHB
  Ala2-Phe128
  Accession # Q15464
• Specificity: Detects human SHB in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SHB
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for SHB Antibody [Janelia Fluor® 646]

• bA3J10.2
• RP11-3J10.8
• SH2 domain-containing adapter protein B
• SHB (Src homology 2 domain containing) adaptor protein B
• SHB adaptor protein (a Src homology 2 protein)
• SHB
• Src homology 2 domain containing adaptor protein B

Background

SHB is an adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. It may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. It may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades, and may also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SHB