SerpinB9 Antibody (7D8) [DyLight 755]


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Product Details

Reactivity Hu, Mu(-), Po(-)Species Glossary
Applications WB, Flow, IHC, IHC-Fr, IHC-P
Please see the vial label for concentration. If unlisted please contact technical services.

SerpinB9 Antibody (7D8) [DyLight 755] Summary

Recombinant PI-9 produced in P. pastoris.
NB100-64359 is specific for human PI-9 (proteinase inhibitor 9), also known as SerpinB9, a 42kDa intracellular nucleocytoplasmic serpin expressed in cytotoxic lymphocytes (CTLs), natural killer (NK) cells, monocyte-derived dendritic cells (DCs), and to a lesser extent in B cells and myeloid cells. Granzyme B (grB) is a serine protease highly expressed by CTLs and NK cells, which is endocytosed by virus-infected and malignant target cells. The subsequent release of grB from the endocytic vesicles into the cytoplasm of the target cells, triggers grB-mediated apoptosis, through cleavage of various cytoplasmic or nuclear proteins. PI-9, up-regulated in response to grB production and degranulation, has been identified as a potent inhibitor of Granzyme B-mediated apoptosis, providing a vital self-protection mechanism against the premature apoptosis of CTLs and NK cells by grB, which may escape into the cytoplasm of the effector cells themselves. Clone 7D8 detects a band of approximately 42kDa under reducing conditions. Clone 7D8 is suitable for use in indirect Immunofluorescence (2).
Protein G purified
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Packaging, Storage & Formulations

Store at 4C in the dark.
DyLight 755
DyLight 755 (A=754, E=776)
50mM Sodium Borate
0.05% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Protein G purified


Application Notes
Membrane permeabilisation is required for this application Flow Cytometry. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.

Reactivity Notes

Reacts with Human. Does not react with Pig or Mouse.


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SerpinB9 Antibody (7D8) [DyLight 755]

  • CAP-3
  • CAP3PI-9
  • Cytoplasmic antiproteinase 3
  • Peptidase inhibitor 9
  • PI9protease inhibitor 9 (ovalbumin type)
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
  • serpin B9
  • serpin peptidase inhibitor, clade B (ovalbumin), member 9
  • serpin peptidase inhibitor, clade B, member 9


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-64359APC
DyLight 350 Labeled NB100-64359UV
DyLight 405 Labeled NB100-64359V
DyLight 405LS Labeled NB100-64359V3
DyLight 488 Labeled NB100-64359G
DyLight 680 Labeled NB100-64359FR
PE Labeled NB100-64359PE
PerCP Labeled NB100-64359PCP

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Contact Information

Product PDFs


Gene Symbol SERPINB9

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