SerpinB9 Products

Antibodies
SerpinB9 Antibody
SerpinB9 Antibody
NBP2-33924
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
SerpinB9 Antibody
SerpinB9 Antibody
NB100-58965
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Lysates
SerpinB9 Overexpression Lysat ...
SerpinB9 Overexpression Lysate (De...
H00005272-T01
Species: Hu
Applications: WB
SerpinB9 Overexpression Lysat ...
SerpinB9 Overexpression Lysate (Na...
NBL1-15851
Applications: WB
Proteins
SerpinB9 Partial Recombinant ...
SerpinB9 Partial Recombinant Protein
H00005272-Q01
Species: Hu
Applications: WB, ELISA, PA
SerpinB9 Recombinant Protein
SerpinB9 Recombinant Protein
H00005272-P01
Species: Hu
Applications: WB, ELISA, PA
SerpinB9 Recombinant Protein ...
SerpinB9 Recombinant Protein Antigen
NBP2-33924PEP
Species: Hu
Applications: AC
RNAi
SerpinB9 RNAi
SerpinB9 RNAi
H00005272-R01
Species: Hu

Description

SerpinB9 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. The mouse orthologue to PI9 is SPI-6. SerpinB9 was first discovered in human bone marrow in a search for serpins similar to SerpinB6. SerpinB9 was identified in lymphocytes, especially natural killer cells and cytotoxic T lymphocytes, cells which also produce and store the apoptosis-inducing enzyme Granzyme B. PI9 was shown to be a potent inhibitor of Granzyme B, working at picamolar efficiencies. PI9 was also shown to inhibit caspase 1, the interleukin 1 converting enzyme, thus blocking IL1 223; production, and decreasing inflammatory processes. Most leukemia cells and many tumor cells produce PI9, leading to speculation that PI9 may help protect tumor cells from destruction by NK and CTL cells. PI9 is also found in placenta, lung, kidney, mast cells, and many tissues and cell lines. In kidney transplant, PI9 is sharply elevated, and in the liver PI9 has been shown to be upregulated by a downstream estrogen promoter. SerpinB9 inhibits Granzyme B, and is cleaved by Granzyme M, as a down regulatory step. SerpinB9 also inhibits the bacterial proteinase subtilisin A, and this may be a protective agent against infections. Neutrophil elastase is also a target of SerpinB9. Like SerpinB6 and SerpinB8, SerpinB9 lacks a signal sequence, and is found mainly in the cytoplasm and nucleus, although it can be detected outside of cells and in serum. The original SerpinB9 sequence described was 379 amino acids in length, with predicted mass of 42.4 kDa and pI of 5.51.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5272
Alternate Names
  • Peptidase inhibitor 9
  • serpin peptidase inhibitor, clade B, member 9
  • Cytoplasmic antiproteinase 3
  • serpin B9
  • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9
  • PI9protease inhibitor 9 (ovalbumin type)
  • CAP3PI-9
  • CAP-3
  • serpin peptidase inhibitor, clade B (ovalbumin), member 9

Research Areas for SerpinB9

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Immunology

PTMs for SerpinB9

Learn more about PTMs related to SerpinB9.

Cleavage
Phosphorylation
Biotinylation

Bioinformatics Tool for SerpinB9

Discover related pathways, diseases and genes to SerpinB9. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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