SerpinB2 Antibody (930109) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: Flow
• Clone: 930109
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

SerpinB2 Antibody (930109) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human Serpin B2
  Glu2-Ala65, Ala99-Pro415
  Accession # P05120
• Specificity: Detects human Serpin B2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SerpinB2 Antibody (930109) [Alexa Fluor® 647]

• HsT1201
• Monocyte Arg-serpin
• PAI
• PAI2
• PAI2Urokinase inhibitor
• Placental plasminogen activator inhibitor
• PLANH2
• PLANH2PAI-2
• plasminogen activator inhibitor 2
• plasminogen activator inhibitor, type II (arginine-serpin)
• serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
• Serpin B2
• serpin peptidase inhibitor, clade B (ovalbumin), member 2
• Urokinase Inhibitor

Background

Serpin B2, also known as Plasminogen Activator Inhibitor 2 (PAI-2), is a 415 amino acid serine-type endopeptidase inhibitor with high expression in blood, vasculature and placenta. Its expression is upregulated in pregnancy and in activated monocytes/macrophages by a wide range of viral, bacterial and parasitic agents. Serpin B2 is upregulated in monocytes from HIV-1 infected patients, and is thought to modulate Th1/Th2 responses. Serpin B2/PAI-2 colocalizes with CHL1 and Vitronectin and mediates neurite outgrowth during post-natal brain development. Inhibition of uPA by SerpinB2 in tumors is associated with a favorable prognosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • P05120()