Serpin A7/TBG Antibody

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Western blot shows human plasma. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Serpin A7/TBG Antigen Affinity-purified Polyclonal Antibody (Catalog # AF8176) followed by HRP-conjugated Anti-Sheep IgG ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Serpin A7/TBG Antibody Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Serpin A7/TBG
Ala21-Ala415
Accession # P05543
Specificity
Detects human Serpin A7/TBG in direct ELISAs and Western blots.  In direct ELISAs, approximately 5% cross-reactivity with recombinant human Serpin A9 is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
SERPINA7
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin A7/TBG Antibody

  • antitrypsin), member 7
  • FLJ17820
  • member 7
  • Serpin A7
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
  • T4-binding globulin
  • TBG
  • TBGclade A (alpha-1 antiproteinase
  • thyroxin-binding globulin
  • thyroxine-binding globulin

Background

Serpin A7 (also TBG/Thyroxine-binding globulin and T4-binding globulin) is a secreted 54 kDa glycoprotein, non-inhibitory member of the serpin family of proteins. It is expressed by the liver and secreted in plasma. Mutations in the SERPINA7 gene can result in a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. A deficiency in TBG result in low serum total T4 and T3 count in clinically euthyroid subjects in the presence of normal serum TSH. Over aa21-415, human serpin A7 shares 76% aa sequence identity with mouse serpin A7.        

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SERPINA7
Uniprot