Serpin A6/Cortisol Binding Globulin Antibody (433903) [CoraFluor™ 1]

• Reactivity: Mu
• Applications: WB
• Clone: 433903
• Clonality: Monoclonal
• Host: Rat
• Conjugate: CoraFluor 1

Serpin A6/Cortisol Binding Globulin Antibody (433903) [CoraFluor™ 1] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Serpin A6
  Val23-Ala397
  Accession # Q06770
• Specificity: Detects mouse Serpin A6 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant mouse Serpin A1, A5, B8, C1, D1, E1, E2, F1, F2, I1, recombinant human Serpin A3, A4, B6, B9, G1, I2, or recombinant rat Serpin A6 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: SERPINA6
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Serpin A6/Cortisol Binding Globulin Antibody (433903) [CoraFluor™ 1]

• antitrypsin), member 6
• CBG
• CBGcorticosteroid-binding globulin
• corticosteroid binding globulin
• member 6
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• Serpin A6
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
• transcortin

Background

Corticol binding globulin (CBG or transcotin) binds with high affinity to cortisol in plasma. Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SERPINA6