Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451 + AACT/1452)

Immunohistochemistry-Paraffin: Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451 + AACT/1452) [NBP2-53320]

Product Discontinued

Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451 + AACT/1452) Summary

• Immunogen: Recombinant human Antichymotrypsin (AACT) protein fragment (aa49-187) (exact sequence is proprietary)
• Localization: Cytoplasmic
• Marker: Histiocytoma Marker
• Protein/Peptide Type: Recombinant Protein
• Isotype: IgG1/IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SERPINA3
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.5 - 1 ug/million cells
  • Immunocytochemistry/ Immunofluorescence 0.5 - 1 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml
  • Western Blot 0.5 - 1.0 ug/ml
• Application Notes: IHC-P: Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer pH 6.0 for 10-20 min followed by cooling at RT for 20 minutes
• Theoretical MW: 70 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 10mM PBS with 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Protein A or G purified

Alternate Names for Serpin A3/alpha 1-Antichymotrypsin Antibody (AACT/1451 + AACT/1452)

• AACTMGC88254
• ACTGIG25
• alpha 1-Antichymotrypsin
• alpha-1-antichymotrypsin
• antitrypsin), member 3
• Cell growth-inhibiting gene 24/25 protein
• growth-inhibiting protein 24
• growth-inhibiting protein 25
• member 3
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• serine (or cysteine) proteinase inhibitor, clade A, member 3
• Serpin A3
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

Background

Alpha 1 Antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variation in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SERPINA3