SENP1 Antibody

Images

 
Western Blot: SENP1 Antibody [NBP1-50510] - Analysis of anti-SENP1 antibody with HL60 cell lysate.
Immunohistochemistry-Paraffin: SENP1 Antibody [NBP1-50510] - Analysis of anti-SENP1 antibody with human thymus at concentration 10 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

SENP1 Antibody Summary

Immunogen
KLH-conjugated synthetic peptide between amino acids 28-59 from N-terminal region of human SENP1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SENP1
Purity
Ammonium sulfate precipitation
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Purity
Ammonium sulfate precipitation

Alternate Names for SENP1 Antibody

  • EC 3.4.22
  • EC 3.4.22.-
  • SENP1
  • Sentrin/SUMO-specific protease SENP1
  • sentrin-specific protease 1
  • SUMO1/sentrin specific peptidase 1
  • SUMO1/sentrin specific protease 1
  • SuPr-2

Background

SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the a GGa region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF-2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis. SENP6 localizes to the cytoplasm and releases SUMO-1. Expression of SENP6 is higher in reproductive organs, indicating that it may mediate processes related to reproduction. SENP8 is involved in the release of sentrins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SENP1
Entrez
Uniprot