SENP1 Antibody [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 350

SENP1 Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human SUMO1-Specific Peptidase 1/SENP1
  Glu419-Leu644
  Accession # Q9P0U3
• Specificity: Detects human SUMO1-Specific Peptidase 1/SENP1 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SENP1 Antibody [Alexa Fluor® 350]

• EC 3.4.22
• EC 3.4.22.-
• SENP1
• Sentrin/SUMO-specific protease SENP1
• sentrin-specific protease 1
• SUMO1/sentrin specific peptidase 1
• SUMO1/sentrin specific protease 1
• SuPr-2

Background

SENP1 (Sentrin/SUMO-specific protease) is a member of the SENP family of proteases. Sentrin/SUMO-specific proteases (SENPs) are a group of cysteine-type peptidases that catalyze two essential functions in the SUMO pathways: processing of full-length SUMOs to their mature forms and deconjugation of SUMOs from SUMOlyated proteins. The seven mammalian SENPs share a conserved C-terminal catalytic domain while the N-terminal domains have no significant similarity. Human SENP-1 has broad specificity for the three mammalian SUMOs. It is found in the cytoplasm and nucleus depending on cell type, and is expressed in testis, thymus, pancreas, spleen, liver, ovary and small intestine. It is thought that localization of SENP-1 is vital for the regulation for SUMOylation status of target proteins. The small ubiquitin-like modifier (SUMO) is a member of ubiquitin-like protein family. SUMO modification of the target proteins is a reversible process that regulates many cellular processes including transcription regulation, nuclear localization, centromere segregation and signal transduction. The recombinant human SENP-1 (immunogen) includes the catalytic domain, which has been shown to be sufficient for SENP-1 activity and substrate specificity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.