SATB1 Antibody (815427) [Alexa Fluor® 647]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 815427
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

SATB1 Antibody (815427) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human SATB1
  Met1-Ser260
  Accession # Q01826
• Specificity: Detects human and mouse SATB1 in ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SATB1 Antibody (815427) [Alexa Fluor® 647]

• DNA-binding protein SATB1
• SATB homeobox 1
• SATB1
• special AT-rich sequence binding protein 1 (binds to nuclearmatrix/scaffold-associating DNA's)
• Special AT-rich sequence-binding protein 1

Background

SATB1 (special AT-rich sequence binding protein-1) is an approximately 103 kDa nuclear matrix-associated homeobox transcription factor that binds AT rich DNA sequences at scaffolding protein attachment and viral genome integration sites. It is a key factor integrating higher-order chromatin architecture with gene regulation. Specifically, it is involved in MHC class-I gene organization and chromatin organization in undifferentiated thymocytes. SATB1 is cleaved into 65-70 kDa and 25‑30 kDa fragments during apoptosis. Human SATB1 shares 99% amino acid sequence identity with mouse and rat SATB1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.