SAR1B Antibody

Images

 
Western Blot: SAR1B Antibody [NBP1-06074] - (0.03ug/ml) staining of Mouse Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot: SAR1B Antibody [NBP1-06074] - HEK293 overexpressing SAR1B and probed with (mock transfection in first lane).

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SAR1B Antibody Summary

Immunogen
Peptide with sequence C-DHERLLESKEELD corresponding to internal region according to NP_057187.1.
Epitope
C-DHERLLESKEELD
Specificity
Both reported variants (NP_001028675.1 and NP_057187.1) represent identical protein
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SAR1B
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.03 - 0.1 ug/ml
  • Peptide ELISA Detection limit 1:8000
Application Notes
WB: Approx. 25 kDa band observed in mouse liver and rat liver lysates (calculated MW of 22.4 kDa band according to human NP_057187.1 and mouse NP_079811.1). In transfected HEK293 transiently expressing SAR1B a band of approx. 26 kDa is observed. This band is not observed in the non-transfected HEK293.
Positive Control
SAR1B Lysate (NBL1-15692)
Publications
Read Publication using NBP1-06074.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SAR1B Antibody

  • 2310075M17Rik
  • ANDD
  • CMRD
  • EC 3.6.5
  • GTP-binding protein B
  • GTP-binding protein SAR1b
  • GTP-binding protein Sara
  • SAR1 homolog B (S. cerevisiae)
  • SAR1a gene homolog (S. cerevisiae) 2
  • SAR1a gene homolog 2 (S. cerevisiae)
  • SAR1a gene homolog 2
  • SARA2GTBPB
  • SARB

Background

SAR1B belongs to the small GTPase superfamily, SAR1 family. It is involved in transport from the endoplasmic reticulum to the Golgi apparatus and is activated by the guanine nucleotide exchange factor PREB. SAR1B is involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SAR1B Antibody (NBP1-06074)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SAR1B
Entrez
Uniprot