RNASEH2A Antibody

Images

 
Western Blot: RNASEH2A Antibody [NBP1-76981] - Western blot analysis of RNAse H2A in HeLa cell lysate with RNAse H2A antibody at 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: RNASEH2A Antibody [NBP1-76981] - HeLa cells with RNASEH2A antibody at 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: RNASEH2A Antibody [NBP1-76981] - Hela cells

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

RNASEH2A Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide near the center of human RNAse H2A. The immunogen is located within amino acids 190 - 240 of RNAse H2A.
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RNASEH2A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Theoretical MW
33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
RNASEH2A Peptide (NBP1-76981PEP)
Publications
Read Publication using
NBP1-76981 in the following applications:

  • IP
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RNASEH2A Antibody

  • AGS4RNase H2 subunit A
  • Aicardi-Goutieres syndrome 4 protein
  • Aicardi-Goutieres syndrome 4
  • JUNB
  • ribonuclease H2 subunit A
  • ribonuclease H2, large subunit
  • ribonuclease H2, subunit A
  • Ribonuclease HI large subunit
  • Ribonuclease HI subunit A
  • ribonuclease HI, large subunit
  • RNase H(35)
  • RNASEHIEC 3.1.26.4
  • RNHIARNase HI large subunit
  • RNHL

Background

Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for RNASEH2A Antibody (NBP1-76981)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IP.


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(1)
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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Diseases for RNASEH2A Antibody (NBP1-76981)

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Bioinformatics

Gene Symbol RNASEH2A
Uniprot