RNase L Antibody - BSA Free

Immunohistochemistry-Paraffin: RNase L Antibody [NBP1-87230] - Staining of human small intestine shows weak cytoplasmic positivity in glandular cells.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

RNase L Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit RNase L Antibody - BSA Free (NBP1-87230) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: HGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSI
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RNASEL
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:20 - 1:50
  • Immunohistochemistry-Paraffin 1:20 - 1:50
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  RNase L Recombinant Protein Antigen (NBP1-87230PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for RNase L Antibody - BSA Free

• 2-5A-dependent ribonuclease
• 2-5A-dependent RNase
• 2'-5'-oligoisoadenylate synthetase-dependent
• EC 3.1.26.-
• HPC1
• interferon-induced 2-5A-dependent RNase
• MGC104972
• MGC133329
• PRCA1
• prostate cancer 1
• Ribonuclease 4
• ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent)
• Ribonuclease L
• RNase L
• RNS4DKFZp781D08126

Background

RNase L is a virally induced endoribonuclease that is also the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation through total RNA degradation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L is thought to function in counteracting prostate cancer, via apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RNASEL