Immunohistochemistry-Paraffin: RIPK1/RIP1 Antibody [NB100-56160] - Analysis of RIPK1 in formalin-fixed, paraffin-embedded tonsil using this antibody at 1:2000. A, low magnification overview of a secondary follicle. A1 ...read more
Immunohistochemistry: RIPK1/RIP1 Antibody [NB100-56160] - Analysis of RIP in formalin-fixed, paraffin-embedded tissue sections using NB100-56160 at 1:2000. A, normal human breast. B, normal human colon. Plasma cells in ...read more
WB, IHC, IHC-P, IP
This product is unpurified. The exact concentration of antibody is not quantifiable.
RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD, TRADD, and RIP in their signal transduction pathways. RIP deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.