RIPK1/RIP1 Products

Antibodies
RIPK1/RIP1 Antibody
RIPK1/RIP1 Antibody
NBP1-77077
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
RIPK1/RIP1 Antibody
RIPK1/RIP1 Antibody
NB100-56160
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
RIPK1/RIP1 Antibody (334640) ...
RIPK1/RIP1 Antibody (334640) [Unco...
MAB3585
Species: Hu, Mu, Rt
Applications: WB, Simple Western
Host: Mouse Monoclonal
Lysates
RIPK1/RIP1 Overexpression Lys ...
RIPK1/RIP1 Overexpression Lysate (...
NBL1-15377
Applications: WB
Proteins
RIPK1/RIP1 Partial Recombinan ...
RIPK1/RIP1 Partial Recombinant Pro...
H00008737-Q01
Species: Hu
Applications: WB, ELISA, PA
RIPK1/RIP1 Peptide
RIPK1/RIP1 Peptide
NBP1-77077PEP
Species: Hu
Applications: AC
RIPK1/RIP1 Recombinant Protei ...
RIPK1/RIP1 Recombinant Protein Ant...
NBP1-87128PEP
Species: Hu
Applications: AC
RNAi
RIPK1/RIP1 RNAi
RIPK1/RIP1 RNAi
H00008737-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

RIP (Receptor Interacting Protein) is a 74 kD Ser/Thr kinase which interacts with CD95 (Fas/APO1) receptor and the tumor necrosis factor receptor (TNFR1). It is a cell death domain adapter protein which can bind to the adapter proteins TRADD, RAID (CRADD) and TRAF2. RIP contains an N terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C terminal region containing an intracellular death domain motif. RIP activates both p38 MAP Kinase and SAPK families. In vitro, RIP induces apoptosis, as well as SAPK/JNK and NF-kB activation. NF-kB activation through TRADD, TRAF2 and RIP can be triggered also by DR3/APO3 upon activation with APO3/Tweak ligand. DR4 and DR5 also use FADD, TRADD, and RIP in their signal transduction pathways. RIP deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age. RIP possesses kinase activity as it autophosphorylates itself on serine and threonine residues.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 8737
Alternate Names
  • Rip1 kinase
  • EC 2.7.11.1
  • RIP-1
  • receptor-interacting serine/threonine-protein kinase 1
  • Serine/threonine-protein kinase RIP
  • receptor interacting protein
  • Receptor-interacting protein 1
  • Cell death protein RIP
  • RIPFLJ39204
  • RIP1
  • receptor (TNFRSF)-interacting serine-threonine kinase 1

Research Areas for RIPK1/RIP1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for RIPK1/RIP1

Learn more about PTMs related to RIPK1/RIP1.

Cleavage
Phosphorylation
Ubiquitination
Carboxylation
Reduction
Glycosylation

Bioinformatics Tool for RIPK1/RIP1

Discover related pathways, diseases and genes to RIPK1/RIP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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