Recombinant Mouse TSLP Protein


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Reactivity MuSpecies Glossary
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Recombinant Mouse TSLP Protein Summary

Details of Functionality
Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with mouse IL-7 R alpha. The ED50 for this effect is 0.5-2.5 ng/mL.
Mouse myeloma cell line, NS0-derived mouse TSLP protein
Tyr20-Glu140, with a C-terminal 10-His tag
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
15 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
22-29 kDa, reducing conditions
Read Publications using
555-TS in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TSLP Protein

  • thymic stromal lymphopoietin
  • TSLP


Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220+/IgM- pre-B cells, mouse TSLP promotes the development B220+/IgM+ B cells. Human TSLP was reported to preferentially stimulate myeloid cells; inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c+ dendritic cells. Mouse TSLP cDNA encodes a 140 amino acid (aa) residue precursor protein with a 19 aa signal sequence. Within the mature region, there are three potential N-glycosylation sites and 7 cysteine residues. Mouse TSLP shares approximately 43% aa sequence identity with human TSLP. The gene for mouse TSLP has been localized to chromosome 18. By Northern and RT-PCR analysis, mouse TSLP expression has been detected in spleen, thymus, kidney, lung and bone marrow. TSLP is proposed to signal through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a new member of the hemopoietin receptor family most closely related to R gamma c.

  1. Sims, J.E. et al. (2000) J. Exp. Med. 192:671.
  2. Park, L.S. et al. (2000) J. Exp. Med. 192:659.
  3. Pandey, A. et al. (2000) Nature Immunol. 1:59.
  4. Reche, P.A. et al. (2001) J. Immunol. 167:336.

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Publications for TSLP (555-TS)(28)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, Cell Culture, Enzyme Assay, In Vivo.

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Enzyme Assay
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Showing Publications 1 - 10 of 28. Show All 28 Publications.
Publications using 555-TS Applications Species
K Arae, M Ikutani, K Horiguchi, S Yamaguchi, Y Okada, H Sugiyama, K Orimo, H Morita, H Suto, K Okumura, H Taguchi, K Matsumoto, H Saito, K Sudo, S Nakae Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin Scientific Reports, 2021;11(1):5913. 2021 [PMID: 33723298] (Bioassay, Mouse) Bioassay Mouse
F Yao, Q Yuan, X Song, L Zhou, G Liang, G Jiang, L Zhang Yupingfeng Granule Improves Th2-Biased Immune State in Microenvironment of Hepatocellular Carcinoma through TSLP-DC-OX40L Pathway Evid Based Complement Alternat Med, 2020;2020(0):1263053. 2020 [PMID: 32351590] (Cell Culture, Mouse) Cell Culture Mouse
SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch Cell Rep, 2020;31(1):107472. 2020 [PMID: 32268102] (Bioassay, Mouse) Bioassay Mouse
S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei, NM Santerre, P Loughran, TR Billiar TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway JCI Insight, 2019;4(22):. 2019 [PMID: 31723054] (Bioassay, Mouse) Bioassay Mouse
E Ragonnaud, K Moritoh, M Bodogai, F Gusev, S Garaud, C Chen, X Wang, T Baljinnyam, KG Becker, RW Maul, K Willard-Ga, E Rogaev, A Biragyn Tumor-derived Thymic stromal lymphopoietin expands bone marrow B-cell precursors in circulation to support metastasis Cancer Res., 2019;0(0):. 2019 [PMID: 31575547] (Bioassay, Mouse) Bioassay Mouse
NR Han, PD Moon, HM Kim, HJ Jeong TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway J Clin Med, 2019;8(9):. 2019 [PMID: 31480519] (In Vivo, Mouse) In Vivo Mouse
N Inagaki-Ka, T Ito, M Inaba, Y Azuma, A Tanaka, PTX Vien, K Kibata, A Satake, S Nomura Statins can suppress dendritic cell-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression Eur. J. Immunol., 2019;0(0):. 2019 [PMID: 31269241] (Cell Culture, Mouse) Cell Culture Mouse
JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019;0(0):. 2019 [PMID: 31263279] (Cell Culture, Human) Cell Culture Human
M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice J. Immunol., 2017;0(0):. 2017 [PMID: 28701507] (Bioassay, Mouse) Bioassay Mouse
L Kummola, Z Ortutay, X Chen, S Caucheteux, S Hämäläinen, S Aittomäki, R Yagi, J Zhu, M Pesu, WE Paul, IS Junttila IL-7R? Expression Regulates Murine Dendritic Cell Sensitivity to Thymic Stromal Lymphopoietin J. Immunol., 2017;0(0):. 2017 [PMID: 28404633] (Bioassay, Mouse) Bioassay Mouse
Show All 28 Publications.

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Gene Symbol Tslp