Recombinant Mouse IL-2 Protein

Recombinant Mouse IL-2 (Catalog # 402‑ML) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. The ED50 for this effect is 0.1‑0.4 ng/mL.

1 μg/lane of Recombinant Mouse IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band(s) at 19 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-2 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED₅₀ for this effect is 0.1-0.4 ng/mL.
• Source: E. coli-derived mouse IL-2 protein
  Ala21-Gln169, with and without an N-terminal Met
• Accession #: P04351
• N-terminal Sequence: Ala21 & Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il2
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17.2 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and Tween®-80 with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-2 Protein

• Aldesleukin
• IL2
• IL-2
• IL-2lymphokine
• interleukin 2
• interleukin-2
• involved in regulation of T-cell clonal expansion
• Proleukin
• T cell growth factor
• T-cell growth factor
• TCGF

Background

Interleukin‑2 (IL‑2) is a O‑glycosylated four alpha ‑helix bundle cytokine that has potent stimulatory activity for antigen‑activated T cells. It is expressed by CD4⁺ and CD8⁺ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1‑3). Mature mouse IL‑2 shares 56% and 73% aa sequence identity with human and rat IL‑2, respectively. It shows strain‑specific heterogeneity in an N‑terminal region that contains a poly‑glutamine stretch (4). Mouse and human IL‑2 exhibit cross‑species activity (5). The receptor for IL‑2 consists of three subunits that are present on the cell surface in varying preformed complexes (6‑8). The 55 kDa IL‑2 R alpha is specific for IL‑2 and binds with low affinity. The 75 kDa IL‑2 R beta , which is also a component of the IL‑15 receptor, binds IL‑2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma , which is shared with the receptors for IL‑4, ‑7, ‑9, ‑15, and ‑21, does not independently interact with IL‑2. Upon ligand binding, signal transduction is performed by both IL‑2 R beta and gamma c. IL‑2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL‑2 and IL‑2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas‑induced death of naïve CD4⁺ T cells but not activated CD4⁺ memory lymphocytes (9). IL‑2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (10‑12). Thus, IL‑2 may be a key cytokine in the natural suppression of autoimmunity (13, 14).

1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.
2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109.
3. Kashima, N. et al. (1985) Nature 313:402.
4. Matesanz, F. et al. (1993) Immunogenetics 38:300.
5. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813.
6. Liparoto, S.F. et al. (2002) Biochemistry 41:2543.
7. Wang, X. et al. (2005) Science 310:1159.
8. Bodnar, A. et al. (2008) Immunol. Lett. 116:117.
9. Jaleco, S. et al. (2003) J. Immunol. 171:61.
10. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.
11. Laurence, A. et al. (2007) Immunity 26:371.
12. Kryczek, I. et al. (2007) J. Immunol. 178:6730.
13. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32.
14. Fehervari, Z. et al. (2006) Trends Immunol. 27:109.

Publications for IL-2 (402-ML)(280)

Publications using 402-ML

• Fischer, C;Chen, SS;Nimmerfroh, J;Eugster, A;Stücheli, S;Schulthei beta , C;Widmer, C;Heim, D;Kasenda, B;Passweg, J;Kobold, S;Egli, L;Coianiz, N;Chijioke, O;Chiorazzi, N;Follo, M;Läubli, H;Peipp, M;Binder, M; IGLV3-21R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia Haematologica 2025-09-11 [PMID: 40931870] (In vivo assay, Mouse)
• Xu, W;Li, S;Shan, X;Wang, Q;Chen, X;Wu, S;Gao, Y;Shan, D;Ding, S;Ren, W;Hou, X;Liu, S;Wang, T;Shen, Y;Niu, Z;Xu, H;Sun, L;Yue, W; Targeting tumor-associated CCR2+ macrophages to inhibit pancreatic cancer recurrence following irreversible electroporation Science advances 2025-07-25 [PMID: 40700478] (Bioassay, Mouse)
• Zhang, J;Cao, G;Li, F;Tang, S;Wu, C;Jiang, M;Ye, J;Ju, S;Qian, F;Ding, W; M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer Cell death & disease 2025-07-09 [PMID: 40634299] (Bioassay, Mouse)
• Zhang, J;Tang, H;Wu, H;Pang, X;Jin, R;Zhang, Y; Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-? production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms eLife 2025-05-14 [PMID: 40366856] (Bioassay, Mouse)
• Wang, N;Li, D;Zhang, T;Pachai, MR;Cho, WH;Khudoynazarova, MN;Schoeps, DM;Bao, Y;Liu, M;Tang, L;Yelena, J;Chi, P;Chen, Y; Loss of Kmt2c / d promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy bioRxiv : the preprint server for biology 2025-04-01 [PMID: 40236091] (Bioassay, Mouse)
• Li, Y;Ascui, G;Dicker, M;Riffelmacher, T;Chandra, V;Schmiedel, B;Chou, TF;Vijayanand, P;Kronenberg, M; Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function Nature communications 2025-03-15 [PMID: 40089498] (Bioassay, Mouse)
• Bréart, B;Williams, K;Krimm, S;Wong, T;Kayser, BD;Wang, L;Cheng, E;Cruz Tleugabulova, M;Bouziat, R;Lu, T;Yuen, K;Firmino, NS;Bravo, DD;Roels, J;Bhakta, A;Bevers, J;Lehoux, I;Gutierrez, A;Chestnut, Y;Klementowicz, JE;Arenzana, TL;Akhmetzyanova, I;Dixon, E;Chen, M;Tasneem, K;Yadav, R;Koeppen, H;Oh, SA;Delamarre, L;Huang, H;Lim, SA;Nakamura, G;Wang, J;Gao, C;Corpuz, R;Müller, S;West, NR; IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control Nature 2025-02-05 [PMID: 39910298] (Bioassay, Mouse, Transgenic Mouse)
• Mao, M;Yuan, Y;Li, R;Kuang, Y;Lu, Y;Zhu, W;Chen, W; Modulation of gut propionate and intestinal mucosal protection by Bifidobacterium longum: Mitigating methotrexate side effects without compromising the efficacy of psoriasis therapy International immunopharmacology 2025-02-03 [PMID: 39904035] (Bioassay, Mouse)
• Zotta, A;Toller-Kawahisa, J;Palsson-McDermott, EM;O'Carroll, SM;Henry, ÓC;Day, EA;McGettrick, AF;Ward, RW;Ryan, DG;Watson, MA;Brand, MD;Runtsch, MC;Maitz, K;Lueger, A;Kargl, J;Miljkovic, JL;Lavelle, EC;O'Neill, LAJ; Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion Science advances 2025-01-24 [PMID: 39841829] (Bioassay, Mouse)
• Xie, Y;Liu, Y;Lin, M;Li, Z;Shen, Z;Yin, S;Zheng, Y;Zou, Y;Zhang, Y;Zhan, Y;Fang, Y;Ding, Y; Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity Journal of advanced research 2024-12-19 [PMID: 39708961] (Bioassay, Mouse)
• Westermann, S;Radtke, D;Kramer, L;Wirtz, S;Voehringer, D; Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation European journal of immunology 2024-12-13 [PMID: 39670708] (Bioassay, Transgenic Mouse)
• Hua, L;Yang, Y;Zhang, H;Jiang, X;Jin, C;Feng, B;Che, L;Xu, S;Lin, Y;Wu, D;Zhuo, Y; Adipocyte FGF21 Signaling Defect Aggravated Adipose Tissue Inflammation in Gestational Diabetes Mellitus Nutrients 2024-11-07 [PMID: 39599611] (Bioassay, Mouse)
• Wang, Z;Elbanna, Y;Godet, I;Peters, L;Lampe, G;Chen, Y;Xavier, J;Huse, M;Massagué, J; TGF-? induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis bioRxiv : the preprint server for biology 2024-10-15 [PMID: 39463937] (Bioassay, Human)
• Dietz, S;Hebel, J;Rühle, J;Huff, A;Eltzschig, HK;Lajqi, T;Poets, CF;Gille, C;Köstlin-Gille, N; Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy European journal of immunology 2024-10-25 [PMID: 39460389] (Bioassay, Mouse)
• Thylur Puttalingaiah, R;Dean, MJ;Zheng, L;Philbrook, P;Wyczechowska, D;Kayes, T;Del Valle, L;Danos, D;Sanchez-Pino, MD; Excess Potassium Promotes Autophagy to Maintain the Immunosuppressive Capacity of Myeloid-Derived Suppressor Cells Independent of Arginase 1 Cells 2024-10-19 [PMID: 39451254] (Bioassay, Mouse)
• Zhao, X;Li, F;Cheng, C;Bi, M;Li, J;Cong, J;Wang, X; Social isolation promotes tumor immune evasion via ?2-adrenergic receptor Brain, behavior, and immunity 2024-10-12 [PMID: 39401555] (Bioassay, Mouse)
• May, L;Hu, B;Jerajani, P;Jagdeesh, A;Alhawiti, O;Cai, L;Semenova, N;Guo, C;Isbell, M;Deng, X;Faber, A;Pillappa, R;Bandyopadhyay, D;Wang, XY;Neuwelt, A;Koblinski, J;Bos, PD;Li, H;Martin, R;Landry, JW; The Innate Immune System and TRAIL-BCL-XL Axis Mediate a Sex Bias in Lung Cancer and Confer a Therapeutic Vulnerability in Females Cancer research 2024-09-23 [PMID: 39312191] (Cell Culture, Human)
• Chang, YH;Yamamoto, K;Fujino, T;Wang, TW;Sugimoto, E;Zhang, W;Yabushita, T;Suzaki, K;Pietsch, EC;Weir, BA;Crescenzo, R;Cowley, GS;Attar, R;Philippar, U;Wunderlich, M;Mizukawa, B;Zheng, Y;Enomoto, Y;Imai, Y;Kitamura, T;Goyama, S; SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation Cell reports 2024-07-30 [PMID: 39096901] (Bioassay, Mouse)
• Port, JR;Riopelle, JC;Smith, SG;Myers, L;Kaiser, FK;Lewis, MC;Gallogly, S;Okumura, A;Bushmaker, T;Schulz, JE;Rosenke, R;Prado-Smith, J;Carmody, A;Bane, S;Smith, BJ;Saturday, G;Feldmann, H;Rosenke, K;Munster, VJ; Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis) Nature microbiology 2024-04-22 [PMID: 38649413] (Bioassay, Mouse)
• Choi, SC;Park, YP;Roach, T;Jimenez, D;Fisher, A;Zadeh, M;Ma, L;Sobel, ES;Ge, Y;Mohamadzadeh, M;Morel, L; Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression Science advances 2024-03-29 [PMID: 38536923] (Bioassay, Mouse)
• Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B; Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice Nature communications 2024-02-26 [PMID: 38409097] (Bioassay, Mouse)
• Jiang, B;Zhou, H;Xie, X;Xia, T;Ke, C; Down-regulation of zinc finger protein 335 undermines natural killer cell function in mouse colitis-associated colorectal carcinoma Heliyon 2024-02-29 [PMID: 38375265] (Bioassay, Mouse)
• Hirai, T;Naito, Y;Koyama, S;Nakanishi, Y;Masuhiro, K;Izumi, M;Kuge, T;Naito, M;Mizuno, Y;Yamaguchi, Y;Kang, S;Yaga, M;Futami, Y;Nojima, S;Nishide, M;Morita, T;Kato, Y;Tsuda, T;Takemoto, N;Kinugasa-Katayama, Y;Aoshi, T;Villa, JK;Yamashita, K;Enokida, T;Hoshi, Y;Matsuura, K;Tahara, M;Takamatsu, H;Takeda, Y;Inohara, H;Kumanogoh, A; Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer JCI insight 2024-02-08 [PMID: 38329122] (Stimulation, Mouse)
• Landoni, E;Woodcock, MG;Barragan, G;Casirati, G;Cinella, V;Stucchi, S;Flick, LM;Withers, TA;Hudson, H;Casorati, G;Dellabona, P;Genovese, P;Savoldo, B;Metelitsa, LS;Dotti, G; IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity Nature communications 2024-01-02 [PMID: 38167707] (Bioassay, Human)
• Su, HH;Cheng, CM;Yang, YN;Chang, YW;Li, CY;Wu, ST;Lin, CC;Wu, HE;Suen, JL; Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells Mucosal immunology 2023-10-05 [PMID: 37805143] (Bioassay, Mouse)
• Baumgartner, CK;Ebrahimi-Nik, H;Iracheta-Vellve, A;Hamel, KM;Olander, KE;Davis, TGR;McGuire, KA;Halvorsen, GT;Avila, OI;Patel, CH;Kim, SY;Kammula, AV;Muscato, AJ;Halliwill, K;Geda, P;Klinge, KL;Xiong, Z;Duggan, R;Mu, L;Yeary, MD;Patti, JC;Balon, TM;Mathew, R;Backus, C;Kennedy, DE;Chen, A;Longenecker, K;Klahn, JT;Hrusch, CL;Krishnan, N;Hutchins, CW;Dunning, JP;Bulic, M;Tiwari, P;Colvin, KJ;Chuong, CL;Kohnle, IC;Rees, MG;Boghossian, A;Ronan, M;Roth, JA;Wu, MJ;Suermondt, JSMT;Knudsen, NH;Cheruiyot, CK;Sen, DR;Griffin, GK;Golub, TR;El-Bardeesy, N;Decker, JH;Yang, Y;Guffroy, M;Fossey, S;Trusk, P;Sun, IM;Liu, Y;Qiu, W;Sun, Q;Paddock, MN;Farney, EP;Matulenko, MA;Beauregard, C;Frost, JM;Yates, KB;Kym, PR;Manguso, RT; The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity Nature 2023-10-04 [PMID: 37794185] (Bioassay, Mouse)
• Jiao, D;Sun, R;Ren, X;Wang, Y;Tian, P;Wang, Y;Yuan, D;Yue, X;Wu, Z;Li, C;Gao, L;Ma, C;Liang, X; Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity Cell reports 2023-10-03 [PMID: 37792534] (Bioassay, Human)
• van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E; CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1 European journal of immunology 2023-09-08 [PMID: 37683186] (Bioassay, Mouse)
• Zhao, H;Wu, L;Dai, J;Sun, K;Zi, Z;Guan, J;Zhang, L; Ligand-based adoptive T cell targeting CA125 in ovarian cancer Journal of translational medicine 2023-09-05 [PMID: 37670338] (Cell Culture, Mouse)
• van der Ploeg, EK;Krabbendam, L;Vroman, H;van Nimwegen, M;de Bruijn, MJW;de Boer, GM;Bergen, IM;Kool, M;Tramper-Standers, GA;Braunstahl, GJ;Huylebroeck, D;Hendriks, RW;Stadhouders, R; Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations Nature communications 2023-08-23 [PMID: 37612281] (In vivo assay, Mouse)
• Tamura, S;Ishiguro, H;Suwabe, T;Katagiri, T;Cho, K;Fuse, K;Shibasaki, Y;Mikami, T;Shindo, T;Kitagawa, H;Igarashi, M;Sone, H;Masuko, M;Ushiki, T; Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity Scientific reports 2023-08-11 [PMID: 37567982] (Bioassay, Mouse)
• Rashu, R;Ninkov, M;Wardell, CM;Benoit, JM;Wang, NI;Meilleur, CE;D'Agostino, MR;Zhang, A;Feng, E;Saeedian, N;Bell, GI;Vahedi, F;Hess, DA;Barr, SD;Troyer, RM;Kang, CY;Ashkar, AA;Miller, MS;Haeryfar, SMM; Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens PLoS pathogens 2023-06-29 [PMID: 37384813] (Bioassay, Mouse)
• Suzuki, K;Kunisada, Y;Miyamura, N;Eikawa, S;Hurtado de Mendoza, T;Mose, ES;Lu, C;Kuroda, Y;Ruoslahti, E;Lowy, AM;Sugahara, KN; Tumor-resident regulatory T cells in pancreatic cancer express the ?v?5 integrin as a targetable activation marker bioRxiv : the preprint server for biology 2023-05-24 [PMID: 37292693] (Bioassay, Mouse)
• Naito, Y;Koyama, S;Masuhiro, K;Hirai, T;Uenami, T;Inoue, T;Osa, A;Machiyama, H;Watanabe, G;Sax, N;Villa, J;Kinugasa-Katayama, Y;Nojima, S;Yaga, M;Hosono, Y;Okuzaki, D;Satoh, S;Tsuda, T;Nakanishi, Y;Suga, Y;Morita, T;Fukushima, K;Nishide, M;Shiroyama, T;Miyake, K;Iwahori, K;Hirata, H;Nagatomo, I;Yano, Y;Tamiya, M;Kumagai, T;Takemoto, N;Inohara, H;Yamasaki, S;Yamashita, K;Aoshi, T;Akbay, EA;Hosen, N;Shintani, Y;Takamatsu, H;Mori, M;Takeda, Y;Kumanogoh, A; Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation Science advances 2023-05-19 [PMID: 37205755] (Bioassay, Mouse, Transgenic Mouse)
• Laragione, T;Harris, C;Azizgolshani, N;Beeton, C;Bongers, G;Gulko, PS; Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome EBioMedicine 2023-05-16 [PMID: 37201335] (Bioassay, Mouse)
• Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC; Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development Science advances 2023-05-05 [PMID: 37146141] (Bioassay, Mouse)
• CP Camargo, AK Muhuri, Y Alapan, LF Sestito, M Khosla, MP Manspeaker, AS Smith, CM Paulos, SN Thomas A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T�cells with enhanced tumor homing to improve cell therapy Cell Reports, 2023-02-26;42(3):112175. 2023-02-26 [PMID: 36848287] (Bioassay, Human, Mouse)
• Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)
• JA O'Sullivan, FJ Kohlhapp, A Zloza, L Plaza-Roja, B Burke, NO Dulin, JA Guevara-Pa Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFbeta International Journal of Molecular Sciences, 2023-02-15;24(4):. 2023-02-15 [PMID: 36835342] (Bioassay, Mouse, Transgenic Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023-01-29;24(3):. 2023-01-29 [PMID: 36768873] (Bioassay, Mouse)
• WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway International Journal of Molecular Sciences, 2023;24(3):. 2023 [PMID: 36768873] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• W Lin, L Chen, H Zhang, X Qiu, Q Huang, F Wan, Z Le, S Geng, A Zhang, S Qiu, L Chen, L Kong, JJ Lu Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation Nature Communications, 2023-01-17;14(1):265. 2023-01-17 [PMID: 36650153] (Bioassay, Mouse)
• T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival Mucosal Immunology, 2023-01-13;0(0):. 2023-01-13 [PMID: 36642378] (Bioassay, Mouse)
• D Shore, N Griggs, V Graffeo, ARMR Amin, XM Zha, Y Xu, JP McAleer GPR68 limits the severity of chemical-induced oral epithelial dysplasia Scientific Reports, 2023-01-07;13(1):353. 2023-01-07 [PMID: 36611126] (Differentiation, Differentiation, Mouse)
• M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 2022-11-30;8(48):eadc9657. 2022-11-30 [PMID: 36449620] (Bioassay, Transgenic Mouse)
• S Ganesan, H Acosta, C Brigolin, K Orange, K Trabbic, C Chen, CE Lien, YJ Lin, MY Lin, YS Chuang, A Fattom, V Bitko Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice PLoS ONE, 2022-11-02;17(11):e0272594. 2022-11-02 [PMID: 36322572] (Bioassay, Mouse)
• SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Mouse)
• S Peng, D Xing, L Ferrall, YC Tsai, CF Hung, TC Wu Identification of human MHC-I HPV18 E6/E7-specific CD8?+?T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice Journal of Biomedical Science, 2022-10-12;29(1):80. 2022-10-12 [PMID: 36224625] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• JN Chi, JY Yang, CH Hsueh, CY Tsai, HC Chuang, TH Tan MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation Theranostics, 2022-07-18;12(13):5744-5760. 2022-07-18 [PMID: 35966593] (Cell Culture, Human)
• JH Badrani, AN Strohm, L Lacasa, B Civello, K Cavagnero, YA Haung, M Amadeo, LH Naji, SJ Lund, A Leng, H Kim, RE Baum, N Khorram, M Mondal, G Seumois, J Pilotte, PW Vanderklis, HM McGee, TA Doherty RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R Nature Communications, 2022-07-30;13(1):4435. 2022-07-30 [PMID: 35908044] (Bioassay, Mouse)
• HS Lee, HW Park IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation Journal of Cellular and Molecular Medicine, 2022-07-08;0(0):. 2022-07-08 [PMID: 35801505] (Bioassay, Mouse)
• E Shelkey, D Oommen, ER Stirling, DR Soto-Panto, KL Cook, Y Lu, KI Votanopoul, S Soker Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy Scientific Reports, 2022-06-15;12(1):9983. 2022-06-15 [PMID: 35705580] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
• PL Vu, J Vadakekola, S Idri, H Nicholls, M Cavaignac, S Reeder, MA Khan, D Christense, AG Pockley, SE McArdle A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice Cancers, 2022-04-13;14(8):. 2022-04-13 [PMID: 35454873] (Bioassay, Mouse)
• B Wu, X Zhang, HC Chiang, H Pan, B Yuan, P Mitra, L Qi, H Simonyan, CN Young, E Yvon, Y Hu, N Zhang, R Li RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity Nature Communications, 2022-04-20;13(1):2155. 2022-04-20 [PMID: 35444206] (Bioassay, Mouse)
• S Peng, D Xing, L Ferrall, YC Tsai, RBS Roden, CF Hung, TC Wu Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice MBio, 2022-01-04;0(0):e0325221. 2022-01-04 [PMID: 35089069] (Bioassay, Mouse)
• A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 PloS Pathogens, 2022-01-13;18(1):e1010200. 2022-01-13 [PMID: 35025968] (Bioassay, Mouse)
• M Fleury, C Vazquez-Ma, J Hernandez-, H Dooms Partial STAT5 signaling is sufficient for CD4+ T cell priming but not memory formation Cytokine, 2021-11-26;150(0):155770. 2021-11-26 [PMID: 34839177] (Bioassay, Mouse)
• HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis Science Advances, 2021-10-08;7(41):eabg4167. 2021-10-08 [PMID: 34623912] (Bioassay, Mouse)
• I Safina, ZAN Al Sudani, A Hashoosh, E Darrigues, F Watanabe, AS Biris, RPM Dings, K Bao Vang Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells PLoS ONE, 2021-08-30;16(8):e0241882. 2021-08-30 [PMID: 34460818] (Bioassay, Mouse)
• JL Sun, NP Zhang, RC Xu, GC Zhang, ZY Liu, W Abuduwaili, F Wang, XN Yu, X Shi, GQ Song, H Wu, TT Liu, XZ Shen, B Deng, SQ Weng, L Dong, JM Zhu Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages Journal of Translational Medicine, 2021-08-13;19(1):347. 2021-08-13 [PMID: 34389031] (Bioassay, Mouse)
• ME Kotas, NM Mroz, S Koga, HE Liang, AW Schroeder, RR Ricardo-Go, C Schneider, RM Locksley CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone Mucosal Immunology, 2021-07-21;0(0):. 2021-07-21 [PMID: 34290377] (Bioassay, Mouse)
• T Katsuyama, VR Moulton Splicing factor SRSF1 is indispensable for regulatory T�cell homeostasis and function Cell Reports, 2021-07-06;36(1):109339. 2021-07-06 [PMID: 34233194] (Bioassay, Mouse)
• J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity Science Advances, 2021-06-16;7(25):. 2021-06-16 [PMID: 34134995] (Bioassay, Mouse)
• CH Hsieh, HC Hsieh, FS Shih, PW Wang, LX Yang, DB Shieh, YC Wang An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment Theranostics, 2021-05-13;11(14):7072-7091. 2021-05-13 [PMID: 34093872] (Bioassay, Mouse)
• S Sheppard, EK Santosa, CM Lau, S Violante, P Giovanelli, H Kim, JR Cross, MO Li, JC Sun Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function Cell Reports, 2021-06-01;35(9):109210. 2021-06-01 [PMID: 34077737] (Bioassay, Mouse)
• Y Wang, C Xie, Y Song, W Xiang, J Peng, L Han, J Ding, Y Guan miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis Journal of Translational Medicine, 2021-05-26;19(1):223. 2021-05-26 [PMID: 34039371] (Bioassay, Mouse)
• H Zhang, D Dai, Q Hu, F Yang, Y Xue, F Li, N Shen, M Zhang, C Huang Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development Cell Reports, 2021-05-11;35(6):109096. 2021-05-11 [PMID: 33979619] (Bioassay, Mouse)
• D Guan, Z Wang, J Huo, S Xu, KP Lam Bruton&#039;s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response Cell Death & Disease, 2021-04-30;12(5):431. 2021-04-30 [PMID: 33931590] (Bioassay, Mouse)
• SH Shin, KA Cho, HS Yoon, SY Kim, HY Kim, Y Pewzner-Ju, SA Jung, WJ Park, AH Futerman, JW Park Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells International Journal of Molecular Sciences, 2021-03-08;22(5):. 2021-03-08 [PMID: 33800208] (Bioassay, Mouse)
• J Lu, S Li, X Li, W Zhao, X Duan, X Gu, J Xu, B Yu, LJ Sigal, Z Dong, L Xie, M Fang Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging Aging Cell, 2021-03-29;0(0):e13353. 2021-03-29 [PMID: 33780118] (Bioassay, Mouse)
• JL Liu, CY Wang, TY Cheng, Youlutuzia, C Ji, M Deng, S Yao, LH Yuan, YY Zhao, T Shen, JM Li Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B-cells in Experimental Colitis and Colitis Associated Colorectal Cancer Cellular and Molecular Gastroenterology and Hepatology, 2021-02-27;0(0):. 2021-02-27 [PMID: 33652118] (Bioassay, Mouse)
• L Fan, Q Wu, S Kang, B Yang, C Wu The phenotypic and functional study of tissue B cells in respiratory system provided important information for diseases and development of vaccines Journal of Cellular and Molecular Medicine, 2021-01-22;0(0):. 2021-01-22 [PMID: 33481318] (Bioassay, Mouse)
• CG Burke, JR Myers, CM Post, LA Boulé, BP Lawrence DNA Methylation Patterns in CD 4 + T Cells of Na�ve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand Environmental health perspectives, 2021-01-15;129(1):17007. 2021-01-15 [PMID: 33449811] (Flow Cytometry, Mouse)
• J Yu, MD Green, S Li, Y Sun, SN Journey, JE Choi, SM Rizvi, A Qin, JJ Waninger, X Lang, Z Chopra, I El Naqa, J Zhou, Y Bian, L Jiang, A Tezel, J Skvarce, RK Achar, M Sitto, BS Rosen, F Su, SP Narayanan, X Cao, S Wei, W Szeliga, L Vatan, C Mayo, MA Morgan, CA Schonewolf, K Cuneo, I Kryczek, VT Ma, CD Lao, TS Lawrence, N Ramnath, F Wen, AM Chinnaiyan, M Cieslik, A Alva, W Zou Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination Nature Medicine, 2021-01-04;0(0):. 2021-01-04 [PMID: 33398162] (Bioassay, Transgenic Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• K Ochiai, M Yamaoka, A Swaminatha, H Shima, H Hiura, M Matsumoto, D Kurotaki, J Nakabayash, R Funayama, K Nakayama, T Arima, T Ikawa, T Tamura, R Sciammas, P Bouvet, TK Kundu, K Igarashi Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 Cell Reports, 2020-12-22;33(12):108517. 2020-12-22 [PMID: 33357426] (Bioassay, Mouse, Transgenic Mouse)
• J Liu, C Yang, T Liu, Z Deng, W Fang, X Zhang, J Li, Q Huang, C Liu, Y Wang, D Yang, GK Sukhova, JS Lindholt, A Diederichs, LM Rasmussen, D Li, G Newton, FW Luscinskas, L Liu, P Libby, J Wang, J Guo, GP Shi Eosinophils improve cardiac function after myocardial infarction Nature Communications, 2020-12-16;11(1):6396. 2020-12-16 [PMID: 33328477] (Bioassay, Mouse)
• GM Wiedemann, S Grassmann, CM Lau, M Rapp, AV Villarino, C Friedrich, G Gasteiger, JJ O'Shea, JC Sun Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells Cell Reports, 2020-12-15;33(11):108498. 2020-12-15 [PMID: 33326784] (Bioassay, Mouse)
• T Koga, F Sasaki, K Saeki, S Tsuchiya, T Okuno, M Ohba, T Ichiki, S Iwamoto, H Uzawa, K Kitajima, C Meno, E Nakamura, N Tada, Y Fukui, J Kikuta, M Ishii, Y Sugimoto, M Nakao, T Yokomizo Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation Cell Mol Immunol, 2020-10-09;0(0):. 2020-10-09 [PMID: 33037399] (Bioassay, Mouse)
• JH Kang, G Katsikis, Z Li, KM Sapp, MA Stockslage, D Lim, MG Vander Hei, MB Yaffe, SR Manalis, TP Miettinen Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division Nat Commun, 2020-10-05;11(1):4983. 2020-10-05 [PMID: 33020492] (Bioassay, Mouse)
• EJ Bassin, AR Buckley, JD Piganelli, SR Little TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model PLoS ONE, 2020-09-23;15(9):e0239396. 2020-09-23 [PMID: 32966314] (Bioassay, Mouse)
• KM Au, SI Park, AZ Wang Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy Sci Adv, 2020-07-03;6(27):eaba8564. 2020-07-03 [PMID: 32923587] (Cell Culture, Mouse)
• W Pan, A Sharabi, AP Ferretti, Y Zhang, C Burbano, N Yoshida, MG Tsokos, GC Tsokos PPP2R2D suppresses interleukin-2 production and regulatory T cell function JCI Insight, 2020-10-02;5(19):. 2020-10-02 [PMID: 32897879] (Bioassay, Mouse)
• K Schmitt, J Curlin, L Remling-Mu, R Moriarty, K Goff, S O'Connor, M Stenglein, P Marx, R Akkina Cross-Species Transmission and Evolution of SIV Chimpanzee Progenitor Viruses Toward HIV-1 in Humanized Mice Front Microbiol, 2020-08-11;11(0):1889. 2020-08-11 [PMID: 32849468] (Bioassay, Mouse)
• J Tur, S Pereira-Lo, T Vico, EA Marín, JP Muñoz, M Hernández-, PJ Cardona, A Zorzano, J Lloberas, A Celada Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity Cell Rep, 2020-08-25;32(8):108079. 2020-08-25 [PMID: 32846136] (Bioassay, Mouse)
• A Villegas-M, G Khandelwal, LM McGowan, RS Dookie, MJ Haley, C George, D Sims, GM Lord, LV Sinclair, RG Jenner, KN Couper Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression J. Immunol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32817333] (Bioassay, Cell Culture, Mouse)
• V Peng, C Georgescu, A Bakowska, A Pankow, L Qian, JD Wren, XH Sun E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells J. Biol. Chem., 2020-08-19;0(0):. 2020-08-19 [PMID: 32817168] (Bioassay, Cell Culture, Mouse)
• JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition Nat. Immunol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32807943] (Bioassay, Mouse)
• MND Svensson, M Zoccheddu, S Yang, G Nygaard, C Secchi, KM Doody, K Slowikowsk, F Mizoguchi, F Humby, R Hands, E Santelli, C Sacchetti, K Wakabayash, DJ Wu, C Barback, R Ai, W Wang, GP Sims, P Mydel, T Kasama, DL Boyle, F Galimi, D Vera, ML Tremblay, S Raychaudhu, MB Brenner, GS Firestein, C Pitzalis, AH Ekwall, SM Stanford, N Bottini Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal Sci Adv, 2020-06-26;6(26):eaba4353. 2020-06-26 [PMID: 32637608] (Bioassay, Mouse)
• J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (Bioassay, Mouse)
• W Li, AS Elshikha, C Cornaby, X Teng, G Abboud, J Brown, X Zou, L Zeumer-Spa, B Robusto, SC Choi, K Fredenburg, A Major, L Morel T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice JCI Insight, 2020-06-04;5(11):. 2020-06-04 [PMID: 32493841] (Bioassay, Transgenic Mouse)
• CW Keller, MB Kotur, S Mundt, N Dokalis, LA Ligeon, AM Shah, M Prinz, B Becher, C Münz, JD Lünemann CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation Autophagy, 2020-05-13;0(0):1-15. 2020-05-13 [PMID: 32401602] (Bioassay, Mouse)
• X Guo, Y Pan, M Xiong, S Sanapala, C Anastasaki, O Cobb, S Dahiya, DH Gutmann Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth Nat Commun, 2020-05-01;11(1):2177. 2020-05-01 [PMID: 32358581] (Cell Culture, Mouse)
• L Simula, M Corrado, B Accordi, A Di Rita, F Nazio, Y Antonucci, A Di Daniele, F Caicci, I Caruana, ME Soriano, M Pigazzi, F Locatelli, F Cecconi, S Campello JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction Cell Death Differ., 2020-04-28;0(0):. 2020-04-28 [PMID: 32346136] (Bioassay, Mouse)
• CA Bessell, A Isser, JJ Havel, S Lee, DR Bell, JW Hickey, W Chaisawang, J Glick Biel, R Srivastava, F Kuo, T Purohit, R Zhou, TA Chan, JP Schneck Commensal bacteria stimulate antitumor responses via T cell cross-reactivity JCI Insight, 2020-04-23;5(8):. 2020-04-23 [PMID: 32324171] (Cell Culture, Mouse)
• H Baek, SY Park, SJ Ku, K Ryu, Y Kim, H Bae, YS Lee Bee Venom Phospholipase A2 Induces Regulatory T Cell Populations by Suppressing Apoptotic Signaling Pathway Toxins (Basel), 2020-03-22;12(3):. 2020-03-22 [PMID: 32235689] (Cell Culture, Mouse)
• W Seo, K Shimizu, S Kojo, A Okeke, T Kohwi-Shig, SI Fujii, I Taniuchi Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity Nat Commun, 2020-03-26;11(1):1562. 2020-03-26 [PMID: 32218434] (Bioassay, Cell Culture, Mouse)
• LA Sacramento, L Benevides, SR Maruyama, L Tavares, KF Fukutani, M Francozo, T Sparwasser, FQ Cunha, RP Almeida, JS da Silva, V Carregaro TLR4 abrogates the Th1 immune response through IRF1 and IFN-&amp;beta to prevent immunopathology during L. infantum infection PLoS Pathog., 2020-03-25;16(3):e1008435. 2020-03-25 [PMID: 32210480] (Bioassay, Mouse)
• M Wagner, KN Ealey, H Tetsu, T Kiniwa, Y Motomura, K Moro, S Koyasu Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s Cell Rep, 2020-02-25;30(8):2743-2757.e5. 2020-02-25 [PMID: 32101749] (Bioassay, Mouse)
• F do Valle D, A Lafont, M Beibel, K Martin, K Darribat, R Cuttat, A Waldt, U Naumann, G Wieczorek, S Gaulis, S Pfister, KD Mertz, J Li, G Roma, M Warncke Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis JCI Insight, 2020-02-13;5(3):. 2020-02-13 [PMID: 32051345] (In Vivo, Mouse)
• JL Galeano Ni, SS Tay, JLE Tearle, J Xie, MA Govendir, D Kempe, J Mazalo, AP Drew, F Colakoglu, SK Kummerfeld, CG Proud, M Biro The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation J. Cell. Sci., 2020-03-05;0(0):. 2020-03-05 [PMID: 32041902] (Cell Culture, Mouse)
• S Steinmann, M Schoedsack, F Heinrich, PC Breda, A Ochel, G Tiegs, K Neumann Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells Sci Rep, 2020-01-23;10(1):1071. 2020-01-23 [PMID: 31974518] (Cell Culture, Mouse)
• Y Mu, J Zhang, Y Liu, J Ma, D Jiang, X Zhang, X Yi, K Cheng, S Shen, Y Yang, R Zhuang, Y Zhang CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340 J. Leukoc. Biol., 2019-12-04;0(0):. 2019-12-04 [PMID: 31802539] (Bioassay, Mouse)
• Y Zhu, L Xing, X Zheng, CX Yang, YJ He, TJ Zhou, QR Jin, HL Jiang Amplification of tumor antigen presentation by NLGplatin to improve chemoimmunotherapy Int J Pharm, 2019-11-19;0(0):118736. 2019-11-19 [PMID: 31756442] (Cell Culture, Mouse)
• P Obeidy, LA Ju, SH Oehlers, NS Zulkhernai, Q Lee, JL Galeano, Niño, R Kwan, S Tikoo, LL Cavanagh, P Mrass, A Cook, SP Jackson, M Biro, B Roediger, M Sixt, W Weninger Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes Immunol. Cell Biol., 2019-12-23;0(0):. 2019-12-23 [PMID: 31698518] (Cell Culture, Mouse)
• A Rose, C von Spee-M, L Kloke, K Wu, A Kühl, P Enghard, GR Burmester, G Riemekaste, JY Humrich IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis Cells, 2019-10-11;8(10):. 2019-10-11 [PMID: 31614462] (In Vivo, Mouse)
• JH Bradley, S Barwick, GQ Horn, E Ullrich, B Best, JP Arnold, RK Gregg Simulated microgravity-mediated reversion of murine lymphoma immune evasion Sci Rep, 2019-10-10;9(1):14623. 2019-10-10 [PMID: 31602007] (Bioassay, Mouse)
• X Qu, J Han, Y Zhang, X Wang, H Fan, F Hua, R Yao TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development J Neuroinflammation, 2019-09-27;16(1):183. 2019-09-27 [PMID: 31561751] (Bioassay, Mouse)
• N Tackett, JH Bradley, EK Moore, SH Baker, SL Minter, B DiGiacinto, JP Arnold, RK Gregg Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity Sci Rep, 2019-09-25;9(1):13825. 2019-09-25 [PMID: 31554863] (Bioassay, Mouse)
• LP Araujo, JT Maricato, MG Guereschi, MC Takenaka, VM Nascimento, FM de Melo, FJ Quintana, PC Brum, AS Basso The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells Cell Rep, 2019-09-17;28(12):3120-3130.e5. 2019-09-17 [PMID: 31533035] (Cell Culture, Mouse)
• T Sasaki, K Moro, T Kubota, N Kubota, T Kato, H Ohno, S Nakae, H Saito, S Koyasu Innate Lymphoid Cells in the Induction of Obesity Cell Rep, 2019-07-02;28(1):202-217.e7. 2019-07-02 [PMID: 31269440] (Bioassay, Mouse)
• JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation J. Leukoc. Biol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31260596] (Bioassay, Mouse)
• L Racioppi, ER Nelson, W Huang, D Mukherjee, SA Lawrence, W Lento, AM Masci, Y Jiao, S Park, B York, Y Liu, AE Baek, DH Drewry, WJ Zuercher, FR Bertani, L Businaro, J Geradts, A Hall, AR Means, N Chao, CY Chang, DP McDonnell CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer Nat Commun, 2019-06-04;10(1):2450. 2019-06-04 [PMID: 31164648] (Bioassay, Mouse)
• K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death J. Immunol., 2019-05-31;0(0):. 2019-05-31 [PMID: 31152078] (Bioassay, Mouse)
• MB Jones, CA Alvarez, JL Johnson, JY Zhou, N Morris, BA Cobb CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation PLoS ONE, 2019-05-23;14(5):e0216893. 2019-05-23 [PMID: 31120919] (Bioassay, Mouse)
• M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, C Chen, S Rafi, AX Zhu, YX Feng, D Zhu Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells Sci Adv, 2019-05-08;5(5):eaau5240. 2019-05-08 [PMID: 31086813] (Bioassay, Human, Mouse)
• H Dong, NM Adams, Y Xu, J Cao, DSJ Allan, JR Carlyle, X Chen, JC Sun, LH Glimcher The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc Nat. Immunol., 2019-05-13;0(0):. 2019-05-13 [PMID: 31086333] (Stimulation, Mouse)
• MH McGuire, SM Herbrich, SK Dasari, SY Wu, Y Wang, R Rupaimoole, G Lopez-Bere, KA Baggerly, AK Sood Pan-cancer genomic analysis links 3&#039;UTR DNA methylation with increased gene expression in T cells EBioMedicine, 2019-05-02;0(0):. 2019-05-02 [PMID: 31056473] (Bioassay, Mouse)
• C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism Cell Rep, 2019-04-30;27(5):1434-1445.e3. 2019-04-30 [PMID: 31042471] (Bioassay, Mouse)
• A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis PLoS ONE, 2019-04-26;14(4):e0215981. 2019-04-26 [PMID: 31026283] (Bioassay, Mouse)
• M Ott, E Avendaño-G, E Ullrich, C Dreyer, J Strauss, M Harden, M Schön, MP Schön, G Bernhardt, C Stadelmann, C Wegner, W Brück, S Nessler Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity J Neuroinflammation, 2019-02-26;16(1):49. 2019-02-26 [PMID: 30808363] (Bioassay, Mouse)
• J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance Cell Rep, 2018-12-18;25(12):3329-3341.e5. 2018-12-18 [PMID: 30566860] (Bioassay, Mouse)
• L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming Cell Rep, 2018-12-11;25(11):3059-3073.e10. 2018-12-11 [PMID: 30540939] (Bioassay, Mouse)
• AM Falcão, D van Brugge, S Marques, M Meijer, S Jäkel, E Agirre, Samudyata, EM Floriddia, DP Vanichkina, C Ffrench-Co, A Williams, AO Guerreiro-, G Castelo-Br Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis Nat. Med., 2018-11-12;0(0):. 2018-11-12 [PMID: 30420755] (Bioassay, Mouse)
• S Liu, M Xu, C Zhu, Q Zhao, F Zhou Taste Receptor T1R1/T1R3 Promotes the Tumoricidal Activity of Hepatic CD49a+CD49b- Natural Killer Cells Eur. J. Immunol., 2018-10-10;0(0):. 2018-10-10 [PMID: 30259960] (Bioassay, Mouse)
• V Jelen?i?, M Šestan, I Kavazovi?, M Lenarti?, S Marinovi?, TD Holmes, M Prchal-Mur, B Lisni?, V Sexl, YT Bryceson, FM Wensveen, B Poli? NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development Nat. Immunol., 2018-09-17;0(0):. 2018-09-17 [PMID: 30224819] (Bioassay, Mouse)
• S Kojo, N Yasmin, S Muroi, M Tenno, I Taniuchi Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene Nat Commun, 2018-09-05;9(1):3593. 2018-09-05 [PMID: 30185787] (Cell Culture, Mouse)
• J Wu, J Gu, S Zhou, H Lu, Y Lu, L Lu, X Wang Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function J Immunol Res, 2018-08-07;2018(0):1605341. 2018-08-07 [PMID: 30159338] (Bioassay, Mouse)
• CD Geary, C Krishna, CM Lau, NM Adams, SV Gearty, Y Pritykin, AR Thomsen, CS Leslie, JC Sun Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection Cell Rep, 2018-08-21;24(8):1949-1957.e6. 2018-08-21 [PMID: 30134157] (Bioassay, Mouse)
• SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions Mucosal Immunol, 2018-08-07;0(0):. 2018-08-07 [PMID: 30087443] (Bioassay, Mouse)
• HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection Mucosal Immunol, 2018-07-23;0(0):. 2018-07-23 [PMID: 30038214] (Bioassay, Mouse)
• X Zhang, X Xiao, P Lan, J Li, Y Dou, W Chen, N Ishii, S Chen, B Xia, K Chen, E Taparowsky, XC Li OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms Cell Rep, 2018-07-17;24(3):607-618. 2018-07-17 [PMID: 30021159] (Bioassay, Mouse)
• Y Omata, M Frech, T Primbs, S Lucas, D Andreev, C Scholtysek, K Sarter, M Kindermann, N Yeremenko, DL Baeten, N Andreas, T Kamradt, A Bozec, A Ramming, G Krönke, S Wirtz, G Schett, MM Zaiss Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice Cell Rep, 2018-07-03;24(1):169-180. 2018-07-03 [PMID: 29972778] (In Vivo, Mouse)
• HH Abdul-Raza, CJ Rocca, SJ Howe, ME Alonso-Fer, J Wang, R Gabriel, CC Bartholoma, CHV Gan, MI Garín, A Roberts, MP Blundell, V Prakash, FJ Molina-Est, J Pantoglou, G Guenechea, MC Holmes, PD Gregory, C Kinnon, C von Kalle, M Schmidt, JA Bueren, AJ Thrasher, RJ Yáñez-Muño Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency Sci Rep, 2018-05-29;8(1):8214. 2018-05-29 [PMID: 29844458] (Bioassay, Mouse)
• S Teruya, T Okamura, T Komai, M Inoue, Y Iwasaki, S Sumitomo, H Shoda, K Yamamoto, K Fujio Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells Sci Rep, 2018-05-04;8(1):7021. 2018-05-04 [PMID: 29728568] (Bioassay, Mouse)
• D Herndler-B, H Ishigame, R Shinnakasu, V Plajer, C Stecher, J Zhao, M Lietzenmay, L Kroehling, A Takumi, K Kometani, T Inoue, Y Kluger, SM Kaech, T Kurosaki, T Okada, RA Flavell KLRG1+Effector CD8+T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity Immunity, 2018-04-03;0(0):. 2018-04-03 [PMID: 29625895] (Bioassay, Mouse)
• Y Ouchi, A Patil, Y Tamura, H Nishimasu, A Negishi, SK Paul, N Takemura, T Satoh, Y Kimura, M Kurachi, O Nureki, K Nakai, H Kiyono, S Uematsu Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing Int. Immunol., 2018-04-03;30(4):141-154. 2018-04-03 [PMID: 29617862] (Bioassay, Mouse)
• D Chennamadh, NA Saavedra-A, LJ Carreño, MJ Guberman-P, P Arora, T Yongqing, HF Koay, DI Godfrey, S Keshipeddy, SK Richardson, S Sundararaj, JH Lo, X Wen, JA Gascón, W Yuan, J Rossjohn, J Le Nours, SA Porcelli, AR Howell Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity Cell Chem Biol, 2018-03-22;0(0):. 2018-03-22 [PMID: 29576533] (Bioassay, Mouse)
• R Yang, T Yu, D Liu, S Shi, Y Zhou Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 2018-03-09;9(1):62. 2018-03-09 [PMID: 29523215] (Mouse)
• S Cosenza, K Toupet, M Maumus, P Luz-Crawfo, O Blanc-Brud, C Jorgensen, D Noël Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis Theranostics, 2018-02-03;8(5):1399-1410. 2018-02-03 [PMID: 29507629] (Bioassay, Mouse)
• D Zamarin, JM Ricca, S Sadekova, A Oseledchyk, Y Yu, WM Blumensche, J Wong, M Gigoux, T Merghoub, JD Wolchok PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy J. Clin. Invest., 2018-03-05;0(0):. 2018-03-05 [PMID: 29504948] (Bioassay, Mouse)
• H Zhong, Y Liu, Z Xu, P Liang, H Yang, X Zhang, J Zhao, J Chen, S Fu, Y Tang, J Lv, J Wang, N Olsen, A Xu, SG Zheng TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells Front Immunol, 2018-01-30;9(0):35. 2018-01-30 [PMID: 29441062] (Cell Culture, Mouse)
• A Seki, S Rutz Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells J. Exp. Med., 2018-02-07;0(0):. 2018-02-07 [PMID: 29436394] (Cell Culture, Mouse)
• CT Petersen, M Hassan, AB Morris, J Jeffery, K Lee, N Jagirdar, AD Staton, SS Raikar, HT Spencer, T Sulchek, CR Flowers, EK Waller Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3K? inhibitors and VIP antagonists Blood Adv, 2018-02-13;2(3):210-223. 2018-02-13 [PMID: 29386194] (Bioassay, Mouse)
• SK Varanasi, U Jaggi, N Hay, BT Rouse Hexokinase II may be dispensable for CD4 T cell responses against a virus infection PLoS ONE, 2018-01-19;13(1):e0191533. 2018-01-19 [PMID: 29352298] (Bioassay, Mouse)
• M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms Mucosal Immunol, 2017-12-20;11(3):615-626. 2017-12-20 [PMID: 29346348] (Bioassay, Mouse)
• W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang Crucial role of OX40/OX40L signaling in a murine model of asthma Mol Med Rep, 2018-01-18;0(0):. 2018-01-18 [PMID: 29344664] (Bioassay, Mouse)
• K Dai, Y Huang, Z Chen, X Sun, L Yang, Y Jiang Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model Eur. J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29331106] (Bioassay, Mouse)
• Tao Liao, Youqiu Xue, Daqiang Zhao, Siwen Li, Mingyu Liu, Jingrong Chen et al. In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-beta -Induced CD4+Foxp3+ Regulatory T Cells Frontiers in Immunology 2017-10-16 [PMID: 29085374] (Bioassay, Mouse)
• X Fu, F Sun, F Wang, J Zhang, B Zheng, J Zhong, T Yue, X Zheng, JF Xu, CY Wang Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression Mediators Inflamm., 2017-09-19;2017(0):5706152. 2017-09-19 [PMID: 29056830] (Bioassay, Mouse)
• W Lin, X Man, P Li, N Song, Y Yue, B Li, Y Li, Y Sun, Q Fu NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis Sci Rep, 2017-10-16;7(1):12895. 2017-10-16 [PMID: 29038541] (Bioassay, Mouse)
• SK Varanasi, D Donohoe, U Jaggi, BT Rouse Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768727] (Bioassay, Mouse)
• T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768723] (Bioassay, Mouse)
• G Nagalingam, CG Vinuesa, WJ Britton, BM Saunders Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747346] (Bioassay, Mouse)
• W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 2017-07-21;10(1):348. 2017-07-21 [PMID: 28732522] (Bioassay, Mouse)
• M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice J. Immunol., 2017-07-12;0(0):. 2017-07-12 [PMID: 28701507] (Bioassay, Mouse)
• LT McDonald, SD Johnson, DL Russell, MRI Young, AC LaRue Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis PLoS ONE, 2017-07-10;12(7):e0180724. 2017-07-10 [PMID: 28700752] (Bioassay, Mouse)
• Z You, M Timilshina, BS Jeong, JH Chang BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway Eur. J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28681958] (Bioassay, Mouse)
• HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity Biochem. Biophys. Res. Commun., 2017-06-12;0(0):. 2017-06-12 [PMID: 28619514] (Bioassay, Mouse)
• IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells Eur. J. Immunol., 2017-06-29;0(0):. 2017-06-29 [PMID: 28598502] (Bioassay, Mouse)
• K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor Cell Mol Gastroenterol Hepatol, 2017-04-11;4(1):135-151. 2017-04-11 [PMID: 28593185] (Bioassay, Mouse)
• H Yang, HZ Guo, XY Li, J Lin, W Zhang, JM Zhao, HX Zhang, SJ Chen, Z Chen, J Zhu Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance J. Immunol., 2017-05-26;0(0):. 2017-05-26 [PMID: 28550197] (Bioassay, Mouse)
• HF Moffett, ANR Cartwright, HJ Kim, J Godec, J Pyrdol, T Äijö, GJ Martinez, A Rao, J Lu, TR Golub, H Cantor, AH Sharpe, CD Novina, KW Wucherpfen The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection Nat. Immunol., 2017-05-22;0(0):. 2017-05-22 [PMID: 28530712] (Bioassay, Mouse)
• VS Pelly, SM Coomes, Y Kannan, M Gialitakis, LJ Entwistle, J Perez-Llor, S Czieso, IS Okoye, D Rückerl, JE Allen, F Brombacher, MS Wilson Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths J. Exp. Med., 2017-05-15;214(6):1809-1826. 2017-05-15 [PMID: 28507062] (Bioassay, Mouse)
• SY Qu, YL He, J Zhang, CG Wu Transcription factor RBP-J-mediated signaling regulates Basophil&#039;s immunoregulatory function in mouse asthma model Immunology, 2017-07-19;0(0):. 2017-07-19 [PMID: 28493549] (Bioassay, Mouse)
• R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells J. Immunol., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455436] (Bioassay, Mouse)
• X Qu, J Han, Y Zhang, Y Wang, J Zhou, H Fan, R Yao MiR-384 Regulates the Th17/Treg Ratio during Experimental Autoimmune Encephalomyelitis Pathogenesis Front Cell Neurosci, 2017-03-28;11(0):88. 2017-03-28 [PMID: 28400721] (Bioassay, Mouse)
• DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population Nat Commun, 2017-04-04;8(0):14919. 2017-04-04 [PMID: 28374774] (Bioassay, Mouse)
• L Tian, A Goldstein, H Wang, H Ching Lo, I Sun Kim, T Welte, K Sheng, LE Dobrolecki, X Zhang, N Putluri, TL Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, WK Decker, C Zong, MT Lewis, XH Zhang Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming Nature, 2017-04-03;0(0):. 2017-04-03 [PMID: 28371798] (Bioassay, Mouse)
• E Oh, JE Oh, J Hong, Y Chung, Y Lee, KD Park, S Kim, CO Yun Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy J Control Release, 2017-03-20;0(0):. 2017-03-20 [PMID: 28336378] (Bioassay, Mouse)
• C Plaza-Sirv, M Schuster, Y Neumann, U Heise, MC Pils, K Schulze-Os, I Schmitz c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity Cell Rep, 2017-01-03;18(1):22-Dec. 2017-01-03 [PMID: 28052242] (Bioassay, Mouse)
• Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation Sci Rep, 2016-12-08;6(0):38387. 2016-12-08 [PMID: 27929069] (Bioassay, Mouse)
• David A Hildeman Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire J. Immunol., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852740] (Bioassay, Mouse)
• John A Hammer Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse J. Cell Biol., 2016-10-31;215(3):383-399. 2016-10-31 [PMID: 27799367] (Bioassay, Mouse)
• BPTF Depletion Enhances T Cell Mediated Antitumor Immunity Cancer Res, 2016-09-20;0(0):. 2016-09-20 [PMID: 27651309] (Bioassay, Mouse)
• Ye-Teng He, Qing-Min Zhang, Quan-Chun Kou, Bo Tang In vitro generation of cytotoxic T lymphocyte response using dendritic cell immunotherapy in osteosarcoma Oncology Letters 2016-08-01 [PMID: 27446401] (Bioassay, Mouse)
• M Rita I Young Premalignant Oral Lesion Cells Elicit Increased Cytokine Production and Activation of T-cells Anticancer Res., 2016-07-01;36(7):3261-70. 2016-07-01 [PMID: 27354582] (Bioassay, Mouse)
• Nimi Marcel Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife, 2016-06-06;5(0):. 2016-06-06 [PMID: 27267497] (Bioassay, Mouse)
• Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion Stem Cells, 2016-05-27;0(0):. 2016-05-27 [PMID: 27145382] (Bioassay, Mouse)
• D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection PLoS Pathog, 2016-04-13;12(4):e1005561. 2016-04-13 [PMID: 27074026] (Bioassay, Mouse)
• BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice Eur J Immunol, 2016-05-12;0(0):. 2016-05-12 [PMID: 27062360] (Bioassay, Mouse)
• K Szklany, E Ruiter, F Mian, W Kunze, J Bienenstoc, P Forsythe, K Karimi Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide PLoS ONE, 2016-03-29;11(3):e0152443. 2016-03-29 [PMID: 27022966] (Bioassay, Mouse)
• Shweta Pasi Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response J Biol Chem, 2016-03-28;291(23):12358-69. 2016-03-28 [PMID: 27022030] (Bioassay, Mouse)
• Ueda H, Zhou J, Xie J, Davis M Distinct Roles of Cytoskeletal Components in Immunological Synapse Formation and Directed Secretion. J Immunol, 2015-09-21;195(9):4117-25. 2015-09-21 [PMID: 26392461] (Bioassay, Mouse)
• Lubeck B, Lapinski P, Oliver J, Ksionda O, Parada L, Zhu Y, Maillard I, Chiang M, Roose J, King P Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol, 2015-05-22;195(1):31-5. 2015-05-22 [PMID: 26002977] (Bioassay, Mouse)
• Beck B, Kim H, O'Brien R, Jadus M, Gillespie G, Cloud G, Hoa N, Langford C, Lopez R, Harkins L, Lamb L Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. PLoS ONE, 2015-05-08;10(5):e0122387. 2015-05-08 [PMID: 25955158] (Bioassay, Mouse)
• Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol, 2015-02-12;16(0):6. 2015-02-12 [PMID: 25879435] (Bioassay, Mouse)
• Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo. J Immunol, 2015-04-03;194(10):4767-76. 2015-04-03 [PMID: 25840913] (Bioassay, Mouse)
• Quan S, Kim H, Dukala D, Sheng J, Soliven B Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy. J Immunol, 2015-03-30;194(9):4175-84. 2015-03-30 [PMID: 25825437] (Bioassay, Mouse)
• Shibuya M, Fujio K, Shoda H, Okamura T, Okamoto A, Sumitomo S, Yamamoto K A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity. Eur J Immunol, 2015-04-28;45(6):1643-53. 2015-04-28 [PMID: 25789709] (Bioassay, Mouse)
• Bergot A, Chaara W, Ruggiero E, Mariotti-Ferrandiz E, Dulauroy S, Schmidt M, von Kalle C, Six A, Klatzmann D TCR sequences and tissue distribution discriminate the subsets of naive and activated/memory Treg cells in mice. Eur J Immunol, 2015-04-07;45(5):1524-34. 2015-04-07 [PMID: 25726757] (Bioassay, Mouse)
• Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun, 2015-02-19;6(0):6329. 2015-02-19 [PMID: 25695838] (Bioassay, Mouse)
• Zhang Y, Hu X, Hu Y, Teng K, Zhang K, Zheng Y, Hong X, Yu K, Wang Y, Liu L Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. J Exp Clin Cancer Res, 2015-02-05;34(0):11. 2015-02-05 [PMID: 25651850] (Bioassay, Mouse)
• Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan D, Wu C, Rangachari M, Pertel T, Jin H, Ahmed R, Anderson A, Kuchroo V An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun, 2015-01-23;6(0):6072. 2015-01-23 [PMID: 25614966] (Bioassay, Mouse)
• Karsten C, Laumonnier Y, Eurich B, Ender F, Broker K, Roy S, Czabanska A, Vollbrandt T, Figge J, Kohl J Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse. J Immunol, 2015-01-14;194(4):1841-55. 2015-01-14 [PMID: 25589074] (Bioassay, Mouse)
• Solt L, Banerjee S, Campbell S, Kamenecka T, Burris T ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes. Endocrinology, 2015-01-05;156(3):869-81. 2015-01-05 [PMID: 25560829] (Bioassay, Mouse)
• Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature, 2014-12-03;518(7539):417-21. 2014-12-03 [PMID: 25470037] (Bioassay, Mouse)
• Benkhoucha M, Molnarfi N, Dunand-Sauthier I, Merkler D, Schneiter G, Bruscoli S, Riccardi C, Tabata Y, Funakoshi H, Nakamura T, Reith W, Santiago-Raber M, Lalive P Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells. J Immunol, 2014-08-11;193(6):2743-52. 2014-08-11 [PMID: 25114100] (Bioassay, Mouse)
• Hagemann U, Gunnarsson L, Geraudie S, Scheffler U, Griep R, Reiersen H, Duncan A, Kiprijanov S Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis. PLoS ONE, 2014-07-31;9(7):e103776. 2014-07-31 [PMID: 25080123] (Bioassay, Mouse)
• Engler D, Reuter S, van Wijck Y, Urban S, Kyburz A, Maxeiner J, Martin H, Yogev N, Waisman A, Gerhard M, Cover T, Taube C, Muller A Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proc Natl Acad Sci U S A, 2014-07-29;111(32):11810-5. 2014-07-29 [PMID: 25074917] (Bioassay, Mouse)
• Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 2014-07-29;211(9):1807-19. 2014-07-29 [PMID: 25073792] (Bioassay, Mouse)
• Liou Y, Wang S, Chang C, Huang P, Hou M, Lai Y, Lee G, Jiang S, Tsai C, Liao N Adipocyte IL-15 regulates local and systemic NK cell development. J Immunol, 2014-07-09;193(4):1747-58. 2014-07-09 [PMID: 25009203] (Bioassay, Mouse)
• Liu C, Wang H, Yu S, Jin R, Tang H, Liu Y, Ge Q, Sun X, Zhang Y Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol, 2014-06-11;193(2):663-72. 2014-06-11 [PMID: 24920844] (Bioassay, Mouse)
• Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3. J Immunol, 2014-05-19;192(12):5599-609. 2014-05-19 [PMID: 24842756] (Bioassay, Mouse)
• Bauer , Christia, Kim , Edward Y, Marangoni , Francesc, Carrizosa , Esteban, Claudio , Natalie, Mempel , Thorsten Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction. J Clin Invest, 2014-05-08;124(6):2425-40. 2014-05-08 [PMID: 24812664] (Bioassay, Mouse)
• Liu F, Kenngott E, Schroter M, Kuhl A, Jennrich S, Watzlawick R, Hoffmann U, Wolff T, Norley S, Scheffold A, Stumhofer J, Saris C, Schwab J, Hunter C, Debes G, Hamann A Timed action of IL-27 protects from immunopathology while preserving defense in influenza. PLoS Pathog, 2014-05-08;10(5):e1004110. 2014-05-08 [PMID: 24809349] (Bioassay, Mouse)
• Beaulieu A, Zawislak C, Nakayama T, Sun J The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection. Nat Immunol, 2014-04-20;15(6):546-53. 2014-04-20 [PMID: 24747678] (Bioassay, Mouse)
• Zhang Y, Jiang L, Zhang M, Lv K Galectin-9 induced myeloid suppressor cells expand regulatory T cells in an IL-10-dependent manner in CVB3-induced acute myocarditis. Int J Mol Sci, 2014-02-25;15(3):3356-72. 2014-02-25 [PMID: 24573249] (Bioassay, Mouse)
• VanGundy , Zachary, Guerau-de-Arellano , Mireia, Baker , Julie D, Strange , Heather, Olivo-Marston , Susan, Muth , Dillon C, Papenfuss , Tracey L Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells. BMC Immunol, 2014-02-18;15(0):8. 2014-02-18 [PMID: 24548459] (Bioassay, Mouse)
• Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells. Immunology, 2014-07-01;142(3):421-30. 2014-07-01 [PMID: 24527810] (Bioassay, Mouse)
• Bhela S, Mulik S, Reddy P, Richardson R, Gimenez F, Rajasagi N, Veiga-Parga T, Osmand A, Rouse B Critical role of microRNA-155 in herpes simplex encephalitis. J Immunol, 2014-02-10;192(6):2734-43. 2014-02-10 [PMID: 24516198] (Bioassay, Mouse)
• Aziz M, Yang W, Matsuo S, Sharma A, Zhou M, Wang P Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis. J Immunol, 2014-01-29;192(5):2305-14. 2014-01-29 [PMID: 24477910] (Bioassay, Mouse)
• Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson A, Roberts A, Wang Y, Shi Y Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res, 2014-01-22;74(5):1576-87. 2014-01-22 [PMID: 24452999] (Bioassay, Mouse)
• Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL. J Immunol, 2014-01-10;192(4):1512-24. 2014-01-10 [PMID: 24415781] (Bioassay, Mouse)
• Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, Huang C, Tan T Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol, 2014-01-08;192(4):1547-57. 2014-01-08 [PMID: 24403530] (Bioassay, Mouse)
• Chen C, Akiyama K, Yamaza T, You Y, Xu X, Li B, Zhao Y, Shi S Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. EMBO Mol Med, 2014-01-08;6(3):322-34. 2014-01-08 [PMID: 24401839] (Bioassay, Human)
• Rothchild A, Jayaraman P, Nunes-Alves C, Behar S iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog, 2014-01-02;10(1):e1003805. 2014-01-02 [PMID: 24391492] (Bioassay, Mouse)
• Zhong W, Su W, Zhang Y, Liu Q, Wu J, Di C, Zhang Z, Xia Z Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation. Immunology, 2014-06-01;142(2):202-15. 2014-06-01 [PMID: 24383680] (Bioassay, Mouse)
• Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses. J Allergy Clin Immunol, 2013-12-22;133(4):1162-74. 2013-12-22 [PMID: 24365136] (Bioassay, Mouse)
• Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med, 2013-12-22;20(1):62-8. 2013-12-22 [PMID: 24362934] (Bioassay, Mouse)
• Nomachi , Akira, Yoshinaga , Masanori, Liu , Jaron, Kanchanawong , Pakorn, Tohyama , Kiyoshi, Thumkeo , Dean, Watanabe , Takeshi, Narumiya , Shuh, Hirata , Takako Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE, 2013-12-16;8(12):e82590. 2013-12-16 [PMID: 24358210] (Bioassay, Mouse)
• Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization. PLoS ONE, 2013-11-18;8(11):e80500. 2013-11-18 [PMID: 24260404] (Bioassay, Mouse)
• Liu , Jia, Jiang , Min, Ma , Zhiyong, Dietze , Kirsten, Zelinskyy , Gennadiy, Yang , Donglian, Dittmer , Ulf, Schlaak , Joerg F, Roggendorf , Michael, Lu , Mengji TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro. J Immunol, 2013-11-13;191(12):6178-90. 2013-11-13 [PMID: 24227786] (Stimulation, Mouse)
• Rojo J, Ojeda G, Acosta Y, Montes-Casado M, Criado G, Portoles P Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo. J Leukoc Biol, 2013-11-08;95(3):441-50. 2013-11-08 [PMID: 24212096] (Bioassay, Mouse)
• Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol, 2013-10-24;34(1):34-43. 2013-10-24 [PMID: 24158516] (Bioassay, Mouse)
• Jachetti , Elena, Mazzoleni , Stefania, Grioni , Matteo, Ricupito , Alessia, Brambillasca , Chiara, Generoso , Luca, Calcinotto , Arianna, Freschi , Massimo, Mondino , Anna, Galli , Rossella, Bellone , Matteo Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses. Oncoimmunology, 2013-04-16;2(5):e24520. 2013-04-16 [PMID: 23762811] (Bioassay, Mouse)
• Hoffmann U, Pink M, Lauer U, Heimesaat M, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U Regulation and migratory role of P-selectin ligands during intestinal inflammation. PLoS ONE, 2013-04-22;8(4):e62055. 2013-04-22 [PMID: 23630623] (Bioassay, Mouse)
• Dudda J, Salaun B, Ji Y, Palmer D, Monnot G, Merck E, Boudousquie C, Utzschneider D, Escobar T, Perret R, Muljo S, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo N, Held W, Gattinoni L, Romero P MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity, 2013-04-18;38(4):742-53. 2013-04-18 [PMID: 23601686] (Bioassay, Mouse)
• Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria. J Immunol, 2013-04-15;190(10):5128-41. 2013-04-15 [PMID: 23589611] (Bioassay, Mouse)
• Kidani , Yoko, Elsaesser , Heidi, Hock , M Benjam, Vergnes , Laurent, Williams , Kevin J, Argus , Joseph P, Marbois , Beth N, Komisopoulou , Evangeli, Wilson , Elizabet, Osborne , Timothy, Graeber , Thomas G, Reue , Karen, Brooks , David G, Bensinger , Steven J Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol, 2013-04-07;14(5):489-99. 2013-04-07 [PMID: 23563690] (Bioassay, Mouse)
• Carey , Kirstyn, Tan , Kheng H, Ng , Judy, Liddicoat , Douglas, Godfrey , Dale I, Cole , Timothy Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells. Endocrinology, 2013-02-20;154(4):1540-52. 2013-02-20 [PMID: 23425966] (Bioassay, Mouse)
• Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol, 2013-02-13;87(9):4835-45. 2013-02-13 [PMID: 23408620] (Bioassay, Mouse)
• Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase. J Immunol, 2012-12-05;190(1):97-105. 2012-12-05 [PMID: 23225886] (Cell Culture, Mouse)
• Arias , Mauricio, Van Roey , Griet A, Tregoning , John S, Moutaftsi , Magdalin, Coler , Rhea N, Windish , Hillarie, Reed , Steven G, Carter , Darrick, Shattock , Robin J Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140. PLoS ONE, 2012-07-19;7(7):e41144. 2012-07-19 [PMID: 22829921] (Bioassay, Mouse)
• Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology, 2012-03-01;1(2):152-161. 2012-03-01 [PMID: 22720236] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, Kasahara M Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair. J. Immunol., 2012-03-07;188(8):3972-9. 2012-03-07 [PMID: 22403443] (Bioassay, Mouse)
• Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J. Immunol., 2012-01-16;188(4):2001-13. 2012-01-16 [PMID: 22250092] (Bioassay, Mouse)
• Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J. Immunol., 2011-12-23;188(3):1503-13. 2011-12-23 [PMID: 22198948] (Bioassay, Mouse)
• Reddy PB, Sehrawat S, Suryawanshi A Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency. J. Immunol., 2011-10-21;187(11):5745-55. 2011-10-21 [PMID: 22021615] (Bioassay, Mouse)
• Monticelli LA, Sonnenberg GF, Abt MC Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat. Immunol., 2011-11-01;12(11):1045-54. 2011-11-01 [PMID: 21946417] (Bioassay, Mouse)
• Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity, 2011-08-11;35(2):273-84. 2011-08-11 [PMID: 21835648] (Bioassay, Mouse)
• El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Bioassay, Mouse)
• Kashiwada M, Cassel SL, Colgan JD NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J., 2011-04-15;30(10):2071-82. 2011-04-15 [PMID: 21499227] (Bioassay, Mouse)
• Smith C, Martinez M, Peet J, Khanna R Differential outcome of IL-2/anti-IL-2 complex therapy on effector and memory CD8+ T cells following vaccination with an adenoviral vector encoding EBV epitopes. J. Immunol., 2011-04-11;186(10):5784-90. 2011-04-11 [PMID: 21482735] (In Vivo, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J. Immunol., 2010-07-21;185(4):2044-50. 2010-07-21 [PMID: 20660352] (Bioassay, Mouse)
• Wildbaum G, Zohar Y, Karin N Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am. J. Pathol., 2010-04-09;176(6):2764-75. 2010-04-09 [PMID: 20382706] (Bioassay, Mouse)
• Emoto M, Shimizu T, Koike H, Yoshizawa I, Hurwitz R, Kaufmann SH, Emoto Y Dissociated expression of natural killer 1.1 and T-cell receptor by invariant natural killer T cells after interleukin-12 receptor and T-cell receptor signalling. Immunology, 2010-01-01;129(1):62-74. 2010-01-01 [PMID: 20028429] (Bioassay, Mouse)
• Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc. Natl. Acad. Sci. U.S.A., 2009-12-14;107(1):204-9. 2009-12-14 [PMID: 20018660] (In Vivo, Mouse)
• Yu J, Wei M, Mao H, Zhang J, Hughes T, Mitsui T, Park IK, Hwang C, Liu S, Marcucci G, Trotta R, Benson DM, Caligiuri MA CD94 defines phenotypically and functionally distinct mouse NK cell subsets. J. Immunol., 2009-10-15;183(8):4968-74. 2009-10-15 [PMID: 19801519] (In Vivo, Mouse)
• Purushothaman D, Sarin A Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis. J. Exp. Med., 2009-06-22;206(7):1515-23. 2009-06-22 [PMID: 19546249] (Bioassay, Mouse)
• Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med., 2009-01-12;206(1):69-78. 2009-01-12 [PMID: 19139170] (Bioassay, Mouse)
• Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis. Circulation, 2008-10-27;118(20):2063-72. 2008-10-27 [PMID: 18955666] (Bioassay, Mouse)
• McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol., 2008-09-15;181(6):4089-97. 2008-09-15 [PMID: 18768865] (Bioassay, Mouse)
• Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. J. Exp. Med., 2008-03-03;205(3):699-710. 2008-03-03 [PMID: 18316417] (Bioassay, Mouse)
• Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, Chiba H, Maenaka K, Kohda D, Fugo K, Kasahara M Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J. Immunol., 2008-02-01;180(3):1678-85. 2008-02-01 [PMID: 18209064] (Bioassay, Mouse)
• Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest., 2007-12-01;117(12):3868-3878. 2007-12-01 [PMID: 18060034] (Bioassay, Mouse)
• Ruzek MC, Waire JS, Hopkins D, Lacorcia G, Sullivan J, Roberts BL, Richards SM, Nahill SR, Williams JM, Scaria A, Dzuris J, Shankara S, Garman RD Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo. Blood, 2007-11-19;111(3):1726-34. 2007-11-19 [PMID: 18025149] (Bioassay, Mouse)
• Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H Protection of CD8+ T cells from activation-induced cell death by IL-18. J. Leukoc. Biol., 2007-03-30;82(1):142-51. 2007-03-30 [PMID: 17400610] (Bioassay, Mouse)
• Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J. Allergy Clin. Immunol., 2007-03-01;119(3):662-70. 2007-03-01 [PMID: 17336616] (Bioassay, Mouse)
• Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat. Genet., 2007-02-04;39(3):329-37. 2007-02-04 [PMID: 17277778] (Bioassay, Mouse)
• Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007-02-15;178(4):2018-27. 2007-02-15 [PMID: 17277105] (Bioassay, Mouse)
• Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. J Ethnopharmacol, 2006-10-19;110(3):532-8. 2006-10-19 [PMID: 17101254] (Bioassay, Mouse)
• Ogawa K, Funaba M, Chen Y, Tsujimoto M Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol., 2006-11-15;177(10):6787-94. 2006-11-15 [PMID: 17082592] (Bioassay, Mouse)
• Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J. Immunol., 2006-10-15;177(8):5041-50. 2006-10-15 [PMID: 17015687] (Bioassay, Mouse)
• de la Fuente MA, Kumar L, Lu B, Geha RS 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol. Cell. Biol., 2006-07-01;26(14):5214-25. 2006-07-01 [PMID: 16809760] (Bioassay, Mouse)
• Christensen JE, de Lemos C, Moos T, Christensen JP, Thomsen AR CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J. Immunol., 2006-04-01;176(7):4235-43. 2006-04-01 [PMID: 16547260] (Bioassay, Mouse)
• Vugmeyster Y, Seshasayee D, Chang W, Storn A, Howell K, Sa S, Nelson T, Martin F, Grewal I, Gilkerson E, Wu B, Thompson J, Ehrenfels BN, Ren S, Song A, Gelzleichter TR, Danilenko DM A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys. Am. J. Pathol., 2006-02-01;168(2):476-89. 2006-02-01 [PMID: 16436662] (Bioassay, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Harrington , Laurie E, Hatton , Robin D, Mangan , Paul R, Turner , Henriett, Murphy , Theresa, Murphy , Kenneth, Weaver , Casey T Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 2005-10-02;6(11):1123-32. 2005-10-02 [PMID: 16200070] (Bioassay, Mouse)
• La Cava A, Ebling FM, Hahn BH Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA. J. Immunol., 2004-09-01;173(5):3542-8. 2004-09-01 [PMID: 15322219] (Bioassay, Mouse)
• Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J. Neurosci., 2004-07-07;24(27):6133-43. 2004-07-07 [PMID: 15240805] (Bioassay, Mouse)
• Upadhya S, Mooteri S, Peckham N, Pai RG Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice. Angiology, 2004-05-01;55(3):289-94. 2004-05-01 [PMID: 15156262] (In Vivo, Mouse)
• Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C Control of Leishmania major in the absence of Tyk2 kinase. Eur. J. Immunol., 2004-02-01;34(2):519-29. 2004-02-01 [PMID: 14768057] (Bioassay, Mouse)
• Brady J, Hayakawa Y, Smyth MJ, Nutt SL IL-21 induces the functional maturation of murine NK cells. J. Immunol., 2004-02-15;172(4):2048-58. 2004-02-15 [PMID: 14764669] (Bioassay, Mouse)
• Nguyen P, Moisini I, Geiger TL Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function. Blood, 2003-08-28;102(13):4320-5. 2003-08-28 [PMID: 12946999] (Bioassay, Mouse)
• Kulms D, Schwarz T Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes. J. Biol. Chem., 2001-01-23;276(16):12849-55. 2001-01-23 [PMID: 11278301] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Il2
• Uniprot:
  • P04351()