Recombinant Mouse IL-1 beta/IL-1F2 Protein

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-1 beta/IL-1F2 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED₅₀ for this effect is 2-10 pg/mL.
• Source: E. coli-derived mouse IL-1 beta/IL-1F2 protein
  Val118-Ser269, with an N-terminal Met
• Accession #: NP_032387
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il1b
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Theoretical MW: 17 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. *1 mg pack size (01M) is supplied as a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-1 beta/IL-1F2 Protein

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The mouse IL-1 beta cDNA encodes a 269 aa precursor. A 117 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17 kDa mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 65%-78% identity with canine, equine, feline, human, porcine, and rhesus IL-1 beta.

1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
5. Gray, P.W. et al. (1986) J. Immunol. 137:3644.
6. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.

Publications for IL-1 beta/IL-1F2 (401-ML)(180)

Publications using 401-ML

• T Osthues, B Zimmer, V Rimola, K Klann, K Schilling, P Mathoor, C Angioni, A Weigert, G Geisslinge, C Münch, K Scholich, M Sisignano The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain Cells, 2020;9(7):. 2020 [PMID: 32708184] (Bioassay, Mouse)
• Y Dong, S Li, Y Lu, X Li, Y Liao, Z Peng, Y Li, L Hou, Z Yuan, J Cheng Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice J Neuroinflammation, 2020;17(1):205. 2020 [PMID: 32635937] (In Vivo, Mouse)
• EM Hanschmann, SF Petry, S Eitner, CC Maresch, N Lingwal, CH Lillig, T Linn Paracrine regulation and improvement of &amp;beta-cell function by thioredoxin Redox Biol, 2020;34(0):101570. 2020 [PMID: 32473461] (Cell Culture, Mouse)
• B Hou, Y Zhang, P Liang, Y He, B Peng, W Liu, S Han, J Yin, X He Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype Cell Death Dis, 2020;11(5):377. 2020 [PMID: 32415059] (Bioassay, Mouse)
• Y Huang, H Wang, Y Hao, H Lin, M Dong, J Ye, L Song, Y Wang, Q Li, B Shan, Y Jiang, H Li, Z Shao, G Kroemer, H Zhang, L Bai, T Jin, C Wang, Y Ma, Y Cai, C Ding, S Liu, Y Pan, W Jiang, R Zhou Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity Nat. Cell Biol., 2020;0(0):. 2020 [PMID: 32367047] (Bioassay, Mouse)
• S Ma, A Zhang, X Li, S Zhang, S Liu, H Zhao, S Wu, L Chen, C Ma, H Zhao MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1 Arthritis Res. Ther., 2020;22(1):99. 2020 [PMID: 32357909] (Bioassay, Mouse)
• SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang Noggin Inhibits IL-1&amp;beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis Cells, 2020;9(4):. 2020 [PMID: 32290085] (Cell Culture, Mouse)
• O Haidar, N O'Neill, CA Staunton, S Bavan, F O'Brien, S Zouggari, U Sharif, A Mobasheri, K Kumagai, R Barrett-Jo Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts Front Physiol, 2020;11(0):226. 2020 [PMID: 32265733] (Bioassay, Mouse)
• T Shimo, H Takebe, T Okui, Y Kunisada, S Ibaragi, K Obata, N Kurio, K Shamsoon, S Fujii, A Hosoya, K Irie, A Sasaki, M Iwamoto Expression and Role of IL-1&amp;beta Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing Int J Mol Sci, 2020;21(7):. 2020 [PMID: 32235405] (Bioassay, Mouse)
• HS Son, J Lee, HI Lee, N Kim, YJ Jo, GR Lee, SE Hong, M Kwon, NY Kim, HJ Kim, JH Park, SY Lee, W Jeong Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 &amp;beta expression Acta Pharm Sin B, 2020;10(3):462-474. 2020 [PMID: 32140392] (Cell Culture, Mouse)
• MA Wheeler, IC Clark, EC Tjon, Z Li, SEJ Zandee, CP Couturier, BR Watson, G Scalisi, S Alkwai, V Rothhammer, A Rotem, JA Heyman, S Thaploo, LM Sanmarco, J Ragoussis, DA Weitz, K Petrecca, JR Moffitt, B Becher, JP Antel, A Prat, FJ Quintana MAFG-driven astrocytes promote CNS inflammation Nature, 2020;0(0):. 2020 [PMID: 32051591] (Cell Culture, Mouse)
• M Ichii, K Oritani, J Toda, H Saito, H Shi, H Shibayama, D Motooka, Y Kitai, R Muromoto, JI Kashiwakur, K Saitoh, D Okuzaki, T Matsuda, Y Kanakura Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress Haematologica, 2020;0(0):. 2020 [PMID: 31974192] (Cell Culture, Mouse)
• C van de Wet, R Aboushoush, AM Manuel, SB Chia, C Erickson, MB MacPherson, JL van der Ve, V Anathy, AE Dixon, CG Irvin, ME Poynter, A van der Vl, EFM Wouters, NL Reynaert, YMW Janssen-He Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease J. Immunol., 2020;204(4):763-774. 2020 [PMID: 31924651] (In Vivo, Mouse)
• P Pan, Q Zhang, W Liu, W Wang, Z Yu, Z Lao, W Zhang, M Shen, P Wan, F Xiao, MA Shereen, W Zhang, Q Tan, Y Liu, X Liu, K Wu, Y Liu, G Li, J Wu Dengue Virus Infection Activates Interleukin-1beta to Induce Tissue Injury and Vascular Leakage Front Microbiol, 2019;10(0):2637. 2019 [PMID: 31824450] (In Vivo, Mouse)
• HG Lee, LK Kim, JM Choi NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17 Mol Ther Methods Clin Dev, 2020;16(0):32-41. 2020 [PMID: 31737742] (Cell Culture, Mouse)
• D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf Cell Rep, 2019;29(5):1203-1220.e7. 2019 [PMID: 31665634] (Bioassay, Mouse)
• S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing Nature, 2019;574(7779):553-558. 2019 [PMID: 31645721] (Cell Culture, Mouse)
• DX Ji, LH Yamashiro, KJ Chen, N Mukaida, I Kramnik, KH Darwin, RE Vance Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra Nat Microbiol, 2019;0(0):. 2019 [PMID: 31611644] (Bioassay, Mouse)
• J Yu, H Zhu, S Taheri, W Mondy, L Bonilha, GS Magwood, D Lackland, RJ Adams, MS Kindy Serum amyloid A-mediated inflammasome activation of microglial cells in cerebral ischemia J. Neurosci., 2019;0(0):. 2019 [PMID: 31611307] (ELISA Standard, Mouse)
• NW Zammit, SN Walters, KL Seeberger, PJ O'Connell, GS Korbutt, ST Grey A20 as an immune tolerance factor can determine islet transplant outcomes JCI Insight, 2019;4(21):. 2019 [PMID: 31581152] (Bioassay, Mouse)
• M Bensellam, JY Chan, K Lee, MV Joglekar, AA Hardikar, T Loudovaris, HE Thomas, JC Jonas, DR Laybutt Phlda3 regulates beta cell survival during stress Sci Rep, 2019;9(1):12827. 2019 [PMID: 31492921] (Bioassay, Mouse)
• TY Chan, CL Yen, YF Huang, PC Lo, PA Nigrovic, CY Cheng, WZ Wang, SY Wu, CC Shieh Increased ILC3s associated with higher levels of IL-1? aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase Eur. J. Immunol., 2019;0(0):. 2019 [PMID: 31350760] (Cell Culture, Mouse)
• G Chen, X Luo, W Wang, Y Wang, F Zhu, W Wang Interleukin-1? Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway Front Cell Neurosci, 2019;13(0):304. 2019 [PMID: 31338026] (Tissue Culture, Rat)
• S Darkwah, N Nago, MG Appiah, PK Myint, E Kawamoto, M Shimaoka, EJ Park Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis Biomedicines, 2019;7(3):. 2019 [PMID: 31323786] (Bioassay, Mouse)
• C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt Bioorg. Chem., 2019;90(0):103077. 2019 [PMID: 31323598] (Cell Culture, Mouse)
• A Lalwani, J Warren, D Liuwantara, WJ Hawthorne, PJ O'Connell, FJ Gonzalez, RA Stokes, J Chen, DR Laybutt, ME Craig, MM Swarbrick, C King, JE Gunton ? Cell Hypoxia-Inducible Factor-1? Is Required for the Prevention of Type 1 Diabetes Cell Rep, 2019;27(8):2370-2384.e6. 2019 [PMID: 31116982] (Bioassay, Mouse)
• DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity Exp. Mol. Med., 2019;51(4):41. 2019 [PMID: 30988419] (Bioassay, Mouse)
• OM Finucane, J Sugrue, A Rubio-Arai, MV Guillot-Se, MA Lynch The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1?-dependent manner in macrophages Sci Rep, 2019;9(1):4034. 2019 [PMID: 30858427] (Bioassay, Mouse)
• Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development EBioMedicine, 2019;0(0):. 2019 [PMID: 30827928] (Cell Culture, Mouse)
• S Morita-Tak, K Nakahara, S Hasegawa-I, A Isonishi, K Tatsumi, H Okuda, T Tanaka, M Kitabatake, T Ito, A Wanaka Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance J Neuroinflammation, 2019;16(1):39. 2019 [PMID: 30764851] (Specificity Control, Mouse)
• JD Glenn, C Liu, KA Whartenby Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung J. Leukoc. Biol., 2019;0(0):. 2019 [PMID: 30762897] (Bioassay, Mouse)
• HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019;10(1):709. 2019 [PMID: 30755603] (Bioassay, Mouse)
• W Li, S Zhao, H Yang, C Zhang, Q Kang, J Deng, Y Xu, Y Ding, S Li Potential Novel Prediction of TMJ-OA: MiR-140-5p Regulates Inflammation Through Smad/TGF-? Signaling Front Pharmacol, 2019;10(0):15. 2019 [PMID: 30728776] (Bioassay, Mouse)
• K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019;10(1):549. 2019 [PMID: 30710091] (Bioassay, Mouse)
• Y Saeki, K Ishiyama, N Ishida, Y Tanaka, H Ohdan Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation Sci Rep, 2019;9(1):1022. 2019 [PMID: 30705364] (Bioassay, Mouse)
• S Das, D Bar-Sagi BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis Oncogene, 2019;0(0):. 2019 [PMID: 30635655] (Cell Culture, Mouse)
• M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018;25(13):3733-3749.e8. 2018 [PMID: 30590045] (Bioassay, Mouse)
• F Dou, X Chu, B Zhang, L Liang, G Lu, J Ding, S Chen EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-?B signaling pathway Mol Brain, 2018;11(1):75. 2018 [PMID: 30563578] (ELISA (Standard), Mouse)
• R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4 Oncogene, 2018;0(0):. 2018 [PMID: 30518876] (Bioassay, Mouse)
• E Engelowski, NF Modares, S Gorressen, P Bouvain, D Semmler, C Alter, Z Ding, U Flögel, J Schrader, H Xu, PA Lang, J Fischer, DM Floss, J Scheller IL-23R Signaling Plays No Role in Myocardial Infarction Sci Rep, 2018;8(1):17078. 2018 [PMID: 30459442] (Bioassay, Mouse)
• F Mathies, N Steffens, D Kleinschmi, F Stuhlmann, FJ Huber, U Roy, T Meyer, M Luetgehetm, M von Peters, O Seiz, J Herkel, C Schramm, RA Flavell, N Gagliani, C Krebs, U Panzer, Z Abdullah, T Strowig, T Bedke, S Huber Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells J. Immunol., 2018;0(0):. 2018 [PMID: 30446566] (Differentiation, Mouse)
• KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism Cell Death Dis, 2018;9(11):1130. 2018 [PMID: 30425241] (Bioassay, Mouse)
• CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses PLoS Pathog., 2018;14(10):e1007406. 2018 [PMID: 30365535] (Bioassay, Mouse)
• JT Benjamin, DJ Moore, C Bennett, R van der Me, A Royce, R Loveland, JL Wynn Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality J. Immunol., 2018;0(0):. 2018 [PMID: 30305325] (In Vivo, Mouse)
• HY Nam, JH Nam, G Yoon, JY Lee, Y Nam, HJ Kang, HJ Cho, J Kim, HS Hoe Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice J Neuroinflammation, 2018;15(1):271. 2018 [PMID: 30231870] (ELISA (Standard), Mouse)
• DB Ballak, S Li, G Cavalli, JL Stahl, IW Tengesdal, JA van Diepen, V Kluck, B Swartzwelt, T Azam, CJ Tack, R Stienstra, T Mandrup-Po, DR Seals, CA Dinarello Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue J. Biol. Chem., 2018;0(0):. 2018 [PMID: 30006351] (Bioassay, Mouse)
• CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice Stem Cell Res Ther, 2018;9(1):183. 2018 [PMID: 29973247] (Bioassay, Mouse)
• JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh Induction of innate immune memory via microRNA targeting of chromatin remodelling factors Nature, 2018;559(7712):114-119. 2018 [PMID: 29950719] (Bioassay, Mouse)
• DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms Mol. Psychiatry, 2019;24(10):1533-1548. 2019 [PMID: 29875474] (In Vivo, Mouse)
• HM Hsiao, R Fernandez, S Tanaka, W Li, JH Spahn, S Chiu, M Akbarpour, D Ruiz-Perez, Q Wu, C Turam, D Scozzi, T Takahashi, HP Luehmann, V Puri, GRS Budinger, AS Krupnick, AV Misharin, KJ Lavine, Y Liu, AE Gelman, A Bharat, D Kreisel Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1? J. Clin. Invest., 2018;128(7):2833-2847. 2018 [PMID: 29781811] (Bioassay, Mouse)
• B Caughron, Y Yang, MRI Young Role of IL-23 signaling in the progression of premalignant oral lesions to cancer PLoS ONE, 2018;13(4):e0196034. 2018 [PMID: 29664967] (Bioassay, Mouse)
• H Kuwata, C Yuzurihara, N Kinoshita, Y Taki, Y Ikegami, S Washio, Y Hirakawa, E Yoda, T Aiuchi, H Itabe, Y Nakatani, S Hara The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts FEBS J., 2018;0(0):. 2018 [PMID: 29637744] (Bioassay, Rat)
• G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 2018;48(3):556-569.e7. 2018 [PMID: 29562202] (Bioassay, Mouse)
• HV Lin, J Wang, J Wang, W Li, X Wang, JT Alston, MK Thomas, DA Briere, SK Syed, AM Efanov GPR142 prompts glucagon-like Peptide-1 release from islets to improve ? cell function Mol Metab, 2018;0(0):. 2018 [PMID: 29506910] (Bioassay, Mouse)
• AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection J. Exp. Med., 2018;0(0):. 2018 [PMID: 29490936] (Bioassay, Mouse)
• CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation Elife, 2018;7(0):. 2018 [PMID: 29469805] (In Vivo, Mouse)
• QH Wang, SW Lv, YY Guo, JX Duan, SY Dong, QS Wang, FM Yu, H Su, HX Kuang Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro Evid Based Complement Alternat Med, 2017;2017(0):8134321. 2017 [PMID: 29456573] (Bioassay, Mouse)
• W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 2018;0(0):. 2018 [PMID: 29432809] (Cell Culture, Mouse)
• A Song, L Zhu, G Gorantla, O Berdysz, SA Amici, M Guerau-de-, KM Madalena, JK Lerch, X Liu, N Quan Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells Sci Rep, 2018;8(1):723. 2018 [PMID: 29335509] (In Vivo, Mouse)
• A Mancini, M Tantucci, P Mazzocchet, A de Iure, V Durante, L Macchioni, C Giampà, A Alvino, L Gaetani, C Costa, A Tozzi, P Calabresi, M Di Filippo Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis Neurobiol. Dis., 2018;0(0):. 2018 [PMID: 29325869] (Bioassay, Mouse)
• H Makino, S Seki, Y Yahara, S Shiozawa, Y Aikawa, H Motomura, M Nogami, K Watanabe, T Sainoh, H Ito, N Tsumaki, Y Kawaguchi, M Yamazaki, T Kimura A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain Sci Rep, 2017;7(1):16983. 2017 [PMID: 29208967] (Bioassay, Mouse)
• SA Smith, AO Samokhin, M Alfadi, EC Murphy, D Rhodes, WML Holcombe, E Kiss-Toth, RF Storey, SP Yee, SE Francis, EE Qwarnstrom The IL-1RI Co-Receptor TILRR (FREM1�Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease JACC Basic Transl Sci, 2017;2(4):398-414. 2017 [PMID: 28920098] (Bioassay, Mouse)
• A Muschaweck, F Petermann, T Korn IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 2017;0(0):. 2017 [PMID: 28855314] (Bioassay, Mouse)
• K Kamizaki, R Doi, M Hayashi, T Saji, M Kanagawa, T Toda, SI Fukada, HH Ho, ME Greenberg, M Endo, Y Minami The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle J. Biol. Chem., 2017;0(0):. 2017 [PMID: 28790171] (Bioassay, Mouse)
• TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath The Role of Inflammation in ?-cell Dedifferentiation Sci Rep, 2017;7(1):6285. 2017 [PMID: 28740254] (Bioassay, Mouse)
• Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype Mol Metab, 2017;6(7):725-736. 2017 [PMID: 28702328] (Bioassay, Human)
• C Wang, CX Xu, Y Alippe, C Qu, J Xiao, E Schipani, R Civitelli, Y Abu-Amer, G Mbalaviele Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells Sci Rep, 2017;7(1):4880. 2017 [PMID: 28687790] (Bioassay, Mouse)
• SY Nam, KY Kim, MH Kim, JB Jang, SY Rah, HJ Chae, JM Lee, HM Kim, HJ Jeong Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan Pharm Biol, 2017;55(1):1856-1862. 2017 [PMID: 28614972] (ELISA (Standard), Mouse)
• IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells Eur. J. Immunol., 2017;0(0):. 2017 [PMID: 28598502] (Bioassay, Mouse)
• Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017;0(0):. 2017 [PMID: 28539431] (Bioassay, Mouse)
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• Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008;58(11):3510-9. 2008 [PMID: 18975342] (Bioassay, Mouse)
• Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology, 2008;149(10):4837-45. 2008 [PMID: 18583425] (In Vivo, Mouse)
• Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 2008;84(3):631-43. 2008 [PMID: 18552204] (Bioassay, Mouse)
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• Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev., 2006;20(18):2527-38. 2006 [PMID: 16980582] (Bioassay, Mouse)
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• Vickers TA, Zhang H, Graham MJ, Lemonidis KM, Zhao C, Dean NM Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2&apos;-O-methoxyethyl-modified oligonucleotide. J. Immunol., 2006;176(6):3652-61. 2006 [PMID: 16517734] (In Vivo, Mouse)
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• Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice. Immunol. Lett., 2005;102(2):158-68. 2005 [PMID: 16216339] (In Vivo, Mouse)
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Bioinformatics

• Gene Symbol: Il1b
• Uniprot:
  • NP_032387()