Recombinant Mouse IL-1 beta/IL-1F2 Protein

Recombinant Mouse IL-1 beta /IL-1F2 (Catalog # 401-ML) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 2‑10 pg/mL.

1 μg/lane of Recombinant Mouse IL1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse IL-1 beta/IL-1F2 Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED₅₀ for this effect is 2-10 pg/mL.
• Source: E. coli-derived mouse IL-1 beta/IL-1F2 protein
  Val118-Ser269, with an N-terminal Met
• Accession #: NP_032387
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Il1b
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 17 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IL-1 beta/IL-1F2 Protein

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The mouse IL-1 beta cDNA encodes a 269 aa precursor. A 117 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5, 6). The 17 kDa mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 65%-78% identity with canine, equine, feline, human, porcine, and rhesus IL-1 beta .

1. Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
2. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
3. Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
4. Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
5. Gray, P.W. et al. (1986) J. Immunol. 137:3644.
6. Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.

Publications for IL-1 beta/IL-1F2 (401-ML)(263)

Publications using 401-ML

• Lilley, RJ;Taylor, KD;Wildman, SSP;Peppiatt-Wildman, CM; Inflammatory mediators act at renal pericytes to elicit contraction of vasa recta and reduce pericyte density along the kidney medullary vascular network Frontiers in physiology 2023-06-09 [PMID: 37362447] (Bioassay, Mouse)
• Zhai, R;Lenga Ma Bonda, W;Leclaire, C;Saint-Béat, C;Theilliere, C;Belville, C;Coupet, R;Blondonnet, R;Bouvier, D;Blanchon, L;Sapin, V;Jabaudon, M; Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome Journal of translational medicine 2023-06-18 [PMID: 37331963] (Bioassay, Mouse)
• Sun, L;Zhang, X;Wu, S;Liu, Y;Guerrero-Juarez, CF;Liu, W;Huang, J;Yao, Q;Yin, M;Li, J;Ramos, R;Liao, Y;Wu, R;Xia, T;Zhang, X;Yang, Y;Li, F;Heng, S;Zhang, W;Yang, M;Tzeng, CM;Ji, C;Plikus, MV;Gallo, RL;Zhang, LJ; Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration Cell reports 2023-06-16 [PMID: 37330908]
• Li, TT;Lin, CL;Chiang, M;He, JT;Hung, CH;Hsieh, CC; Cytokine-Induced Myeloid-Derived Suppressor Cells Demonstrate Their Immunoregulatory Functions to Prolong the Survival of Diabetic Mice Cells 2023-05-29 [PMID: 37296628] (Bioassay, Mouse)
• Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D; Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages Journal of translational medicine 2023-05-22 [PMID: 37217897] (Bioassay, Mouse)
• Wayne, CR;Bremner, L;Faust, TE;Dur�n-Laforet, V;Ampatey, N;Ho, SJ;Feinberg, PA;Arvanitis, P;Ciric, B;Ruan, C;Elyaman, W;Delaney, SL;Vargas, WS;Swedo, S;Menon, V;Schafer, DP;Cutforth, T;Agalliu, D; Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis bioRxiv : the preprint server for biology 2023-05-09 [PMID: 37215000] (Bioassay, Mouse)
• Wan, J;Zhu, Z;He, Z;Wu, H;Chen, A;Zhu, W;Cheng, P; Stevioside protects primary articular chondrocytes against IL-1?-induced inflammation and catabolism by targeting integrin International immunopharmacology 2023-06-01 [PMID: 37167638] (Bioassay, Mouse)
• Qu, Y;Wang, Y;Wang, S;Yu, X;He, Y;Lu, R;Chen, S;Meng, C;Xu, H;Pei, W;Ni, B;Zhang, R;Huang, X;You, H; A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis Computers in biology and medicine 2023-06-01 [PMID: 37141654] (Bioassay, Mouse)
• Slieker, RC;Donnelly, LA;Akalestou, E;Lopez-Noriega, L;Melhem, R;G�ne?, A;Abou Azar, F;Efanov, A;Georgiadou, E;Muniangi-Muhitu, H;Sheikh, M;Giordano, GN;�kerlund, M;Ahlqvist, E;Ali, A;Banasik, K;Brunak, S;Barovic, M;Bouland, GA;Burdet, F;Canouil, M;Dragan, I;Elders, PJM;Fernandez, C;Festa, A;Fitipaldi, H;Froguel, P;Gudmundsdottir, V;Gudnason, V;Gerl, MJ;van der Heijden, AA;Jennings, LL;Hansen, MK;Kim, M;Leclerc, I;Klose, C;Kuznetsov, D;Mansour Aly, D;Mehl, F;Marek, D;Melander, O;Niknejad, A;Ottosson, F;Pavo, I;Duffin, K;Syed, SK;Shaw, JL;Cabrera, O;Pullen, TJ;Simons, K;Solimena, M;Suvitaival, T;Wretlind, A;Rossing, P;Lyssenko, V;Legido Quigley, C;Groop, L;Thorens, B;Franks, PW;Lim, GE;Estall, J;Ibberson, M;Beulens, JWJ;'t Hart, LM;Pearson, ER;Rutter, GA; Identification of biomarkers for glycaemic deterioration in type 2 diabetes Nature communications 2023-05-03 [PMID: 37137910] (Bioassay, Mouse)
• Cho, MJ;Lee, HG;Yoon, JW;Kim, GR;Koo, JH;Taneja, R;Edelson, BT;Lee, YJ;Choi, JM; Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis Experimental & molecular medicine 2023-05-01 [PMID: 37121980] (Bioassay, Mouse)
• WS Lian, RW Wu, JY Ko, YS Chen, SY Wang, H Jahr, FS Wang Inhibition of Histone Lysine Demethylase 6A Promotes Chondrocytic Activity and Attenuates Osteoarthritis Development through Repressing H3K27me3 Enhancement of Wnt10a The international journal of biochemistry & cell biology, 2023-03-05;0(0):106394. 2023-03-05 [PMID: 36871937] (Bioassay, Mouse)
• Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)
• CM Schafer, S Martin-Alm, K Kurylowicz, N Dufton, L Osuna-Alma, ML Wu, CF Johnson, AV Shah, DO Haskard, A Buxton, E Willis, K Wheeler, S Turner, M Chlebicz, RP Scott, S Kovats, A Cleuren, GM Birdsey, AM Randi, CT Griffin Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge bioRxiv : the preprint server for biology, 2023-02-11;0(0):. 2023-02-11 [PMID: 36798267] (Bioassay, Mouse)
• RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)
• PA Dumesic, SE Wilensky, S Bose, JG Van Vranke, SP Gygi, BM Spiegelman RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha bioRxiv : the preprint server for biology, 2023-01-07;0(0):. 2023-01-07 [PMID: 36712038] (Bioassay, Mouse)
• IC Clark, MA Wheeler, HG Lee, Z Li, LM Sanmarco, S Thaploo, CM Polonio, SW Shin, G Scalisi, AR Henry, JM Rone, F Giovannoni, M Charabati, CF Akl, DM Aleman, SEJ Zandee, A Prat, DC Douek, EA Boritz, FJ Quintana, AR Abate Identification of astrocyte regulators by nucleic acid cytometry Nature, 2023-01-04;0(0):. 2023-01-04 [PMID: 36599367] (Bioassay, Mouse)
• G Wang, E Sweren, W Andrews, Y Li, J Chen, Y Xue, E Wier, MP Alphonse, L Luo, Y Miao, R Chen, D Zeng, S Lee, A Li, E Dare, D Kim, NK Archer, SK Reddy, L Resar, Z Hu, EA Grice, MA Kane, LA Garza Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1alpha signaling and glutamine metabolism Science Advances, 2023-01-04;9(1):eabo7555. 2023-01-04 [PMID: 36598999] (Bioassay, Human, Mouse)
• CK Cheng, X Lin, Y Pu, JKY Tse, Y Wang, CL Zhang, X Cao, CW Lau, J Huang, L He, JY Luo, YT Shih, S Wan, CF Ng, L Wang, RCW Ma, JJ Chiu, TF Chan, X Yu Tian, Y Huang SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis Journal of advanced research, 2022-03-01;43(0):187-203. 2022-03-01 [PMID: 36585108] (Organ Culture, Mouse)
• S Zia, BP Hammond, M Zirngibl, A Sizov, CS Baaklini, SP Panda, MFS Ho, KV Lee, A Mainali, MK Burr, S Williams, AV Caprariell, C Power, T Simmen, BJ Kerr, JR Plemel Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance Molecular Neurodegeneration, 2022-12-13;17(1):82. 2022-12-13 [PMID: 36514132] (Bioassay, Mouse)
• YK Kim, JA Walters, ND Moss, KL Wells, R Sheridan, JG Miranda, RKP Benninger, LL Pyle, RM O'Brien, L Sussel, HW Davidson Zinc Transporter 8 Haploinsufficiency Protects Against Beta Cell Dysfunction in Type 1 Diabetes by Increasing Mitochondrial Respiration Molecular Metabolism, 2022-11-05;66(0):101632. 2022-11-05 [PMID: 36347424] (Bioassay, Mouse)
• AG Yates, E Kislitsyna, C Alfonso Ma, J Zhang, AL Sewell, A Goikolea-V, V Cai, LF Alkhader, A Skaland, B Hammond, R Dimitrova, D Batalle, C Fernandes, AD Edwards, P Gressens, C Thornton, HB Stolp Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity Journal of Neuroinflammation, 2022-10-29;19(1):265. 2022-10-29 [PMID: 36309753] (In Vivo, Mouse)
• KK Myo Min, D Rojas-Cana, D Penko, M DeNichilo, MP Cockshell, CB Ffrench, EJ Thompson, O Asplund, CJ Drogemulle, RB Prasad, L Groop, ST Grey, HE Thomas, T Loudovaris, TW Kay, MG Mahoney, CF Jessup, PT Coates, CS Bonder Desmoglein-2 is important for islet function and beta-cell survival Cell Death & Disease, 2022-10-29;13(10):911. 2022-10-29 [PMID: 36309486] (Bioassay, Mouse)
• A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198802] (Bioassay, Mouse)
• L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)
• C Navarrete, A García-Mar, A Correa-Sáe, ME Prados, F Fernández, R Pineda, M Mazzone, M Álvarez-Be, MA Calzado, E Muñoz A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury Journal of Neuroinflammation, 2022-07-09;19(1):177. 2022-07-09 [PMID: 35810304] (Bioassay, Mouse)
• MM Tsai, JL Chen, TH Lee, H Liu, V Shanmugam, HL Hsieh Brain Protective Effect of Resveratrol via Ameliorating Interleukin-1beta-Induced MMP-9-Mediated Disruption of ZO-1 Arranged Integrity Biomedicines, 2022-05-29;10(6):. 2022-05-29 [PMID: 35740292] (Bioassay, Mouse)
• J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu, Z Yao, L Liu, H Zhang, B Luo, X Wang, C Zeng, X Bai, H Zhang, D Cai Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32 Cell Death & Disease, 2022-06-24;13(6):567. 2022-06-24 [PMID: 35739102] (Bioassay, Mouse)
• HZ Yu, BQ Zhu, L Zhu, S Li, LM Wang NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis Oncogene, 2022-12-01;17(12):2765-2770. 2022-12-01 [PMID: 35662227] (Bioassay, Mouse)
• H Kamei, T Ishii, Y Nishii Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 2022-06-02;12(1):9243. 2022-06-02 [PMID: 35654941] (Bioassay, Mouse)
• LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)
• H Jiang, X Lin, W Liang, Y Li, X Yu Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65 Nutrients, 2022-04-18;14(8):. 2022-04-18 [PMID: 35458235] (Bioassay, Mouse)
• HW Cheng, U Mörbe, M Lütge, C Engetschwi, L Onder, M Novkovic, C Gil-Cruz, C Perez-Shib, T Hehlgans, E Scandella, B Ludewig Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function Nature Communications, 2022-04-19;13(1):2027. 2022-04-19 [PMID: 35440118] (Bioassay, Mouse)
• Z Guo, J Lin, K Sun, J Guo, X Yao, G Wang, L Hou, J Xu, J Guo, F Guo Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway Frontiers in Pharmacology, 2022-03-14;13(0):791376. 2022-03-14 [PMID: 35359876] (Bioassay, Mouse)
• N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival Cell Reports, 2022-03-29;38(13):110565. 2022-03-29 [PMID: 35354043] (Bioassay, Mouse)
• A Stancic, T Saksida, M Markelic, M Vucetic, I Grigorov, V Martinovic, D Gajic, A Ivanovic, K Velickovic, N Savic, V Otasevic Ferroptosis as a Novel Determinant of beta-Cell Death in Diabetic Conditions Oxidative Medicine and Cellular Longevity, 2022-03-14;2022(0):3873420. 2022-03-14 [PMID: 35320979] (Cell Culture, Rat)
• S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)
• AS Wilson, KL Randall, JA Pettitt, JI Ellyard, A Blumenthal, A Enders, BJ Quah, T Bopp, CR Parish, A Brüstle Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2 Nature Communications, 2022-01-26;13(1):528. 2022-01-26 [PMID: 35082281] (Bioassay, Mouse)
• JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication Oncogene, 2021-12-31;0(0):101430. 2021-12-31 [PMID: 34979329] (Bioassay, Mouse)
• DK Kaushik, A Bhattachar, BM Lozinski, V Wee Yong Pericytes as mediators of infiltration of macrophages in multiple sclerosis Journal of Neuroinflammation, 2021-12-24;18(1):301. 2021-12-24 [PMID: 34952601] (Bioassay, Mouse)
• Y Duan, H Chu, K Brandl, L Jiang, S Zeng, N Meshgin, E Papachrist, J Argemi, BG Mendes, Y Wang, H Su, W Sun, C Llorente, T Hendrikx, X Liu, M Hosseini, T Kisseleva, DA Brenner, R Bataller, P Ramachandr, M Karin, W Fu, B Schnabl CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease Nature Communications, 2021-12-09;12(1):7172. 2021-12-09 [PMID: 34887405] (Bioassay, Mouse, Transgenic Mouse)
• P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 2021-11-10;11(11):. 2021-11-10 [PMID: 34827481] (Bioassay, Mouse)
• A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 2021-11-23;37(8):110037. 2021-11-23 [PMID: 34818536] (Bioassay, Mouse)
• Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons Journal of Neuroinflammation, 2021-11-08;18(1):261. 2021-11-08 [PMID: 34749758] (Bioassay, Mouse)
• C van de Wet, AM Manuel, M Sharafi, R Aboushoush, X Qian, C Erickson, M MacPherson, G Chan, IM Adcock, N ZounematKe, F Schleich, R Louis, E Bohrnsen, A D'Alessand, EF Wouters, NL Reynaert, J Li, CR Wolf, CJ Henderson, LKA Lundblad, ME Poynter, AE Dixon, CG Irvin, A van der Vl, JL van der Ve, YM Janssen-He Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2 Redox Biology, 2021-10-03;47(0):102160. 2021-10-03 [PMID: 34624602] (Bioassay, In Vivo, Mouse)
• S Lee, A Ishitsuka, T Kuroki, YH Lin, A Shibuya, T Hongu, Y Funakoshi, Y Kanaho, K Nagata, A Kawaguchi Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes JCI Insight, 2021-08-23;6(16):. 2021-08-23 [PMID: 34423792] (In Vivo, Mouse)
• M Han, T Ishikawa, CC Stroupe, HA Breckenrid, JK Bentley, MB Hershenson Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice Mucosal Immunology, 2021-08-05;0(0):. 2021-08-05 [PMID: 34354243] (In Vivo, Mouse)
• L Dupraz, A Magniez, N Rolhion, ML Richard, G Da Costa, S Touch, C Mayeur, J Planchais, A Agus, C Danne, C Michaudel, M Spatz, F Trottein, P Langella, H Sokol, ML Michel Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal &amp;gamma&amp;delta T�cells Cell Reports, 2021-07-06;36(1):109332. 2021-07-06 [PMID: 34233192] (Bioassay, Mouse)
• ELY Chen, CR Lee, PK Thompson, DL Wiest, MK Anderson, JC Zúñiga-Pfl Ontogenic timing, T�cell receptor signal strength, and Notch signaling direct &amp;gamma&amp;delta T�cell functional differentiation in�vivo Cell Reports, 2021-06-08;35(10):109227. 2021-06-08 [PMID: 34107257] (Bioassay, Mouse)
• X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy Redox Biology, 2021-05-25;44(0):102010. 2021-05-25 [PMID: 34082381] (In Vivo, Mouse)
• A Singh, M Dashynam, B Chim, TM Escobar, X Liu, X Hu, S Patnaik, X Xu, N Southall, J Marugan, A Jadhav, V Lazarevic, SA Muljo, M Ferrer Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells Scientific Reports, 2021-06-01;11(1):11498. 2021-06-01 [PMID: 34075120] (Bioassay, Mouse)
• V Farré-Alin, A Palomino-A, P Narros-Fer, AB Lopez-Rodr, C Decouty-Pe, A Muñoz-Mont, J Zamorano-F, B Mansilla-F, J Giner-Garc, P García-Fei, M Sáez-Alegr, AJ Palpán-Flo, JM Roda-Frade, CS Carabias, JM Rosa, B Civantos-M, S Yus-Teruel, L Gandía, A Lagares, BJ Hernández-, J Egea Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients Biomedicines, 2021-05-25;9(6):. 2021-05-25 [PMID: 34070533] (Bioassay, Mouse)
• DW Kwak, D Park, JH Kim Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1&amp;beta Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation Biomedicines, 2021-05-11;9(5):. 2021-05-11 [PMID: 34064821] (Bioassay, Mouse)
• FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes Cell Reports, 2021-05-25;35(8):109176. 2021-05-25 [PMID: 34038731] (Bioassay, Mouse)
• Y Lu, L Liu, J Pan, B Luo, H Zeng, Y Shao, H Zhang, H Guan, D Guo, C Zeng, R Zhang, X Bai, H Zhang, D Cai MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-&amp;kappaB pathway Cell Death & Disease, 2021-05-25;12(6):533. 2021-05-25 [PMID: 34031369] (Cell Culture, Mouse)
• J Zhao, B Cai, Z Shao, L Zhang, Y Zheng, C Ma, F Yi, B Liu, C Gao TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1 Cell Death and Differentiation, 2021-05-20;0(0):. 2021-05-20 [PMID: 34017102] (Bioassay, Mouse)
• R Grieshaber, FA Radtke, P Cunin, G Stifano, A Levescot, B Vijaykumar, N Nelson-Man, RB Blaustein, PA Monach, PA Nigrovic, ImmGen Con The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments Nature Communications, 2021-05-17;12(1):2856. 2021-05-17 [PMID: 34001893] (Bioassay, Mouse)
• A Takahashi, H Aleyasin, MA Stavarache, L Li, F Cathomas, LF Parise, HY Lin, CJ Burnett, A Aubry, ME Flanigan, A Brancato, C Menard, ML Pfau, V Kana, J Wang, GE Hodes, T Sasaki, MG Kaplitt, S Ogawa, BS McEwen, SJ Russo Neuromodulatory effect of interleukin 1&amp;beta in the dorsal raphe nucleus on individual differences in aggression Molecular Psychiatry, 2021-04-30;0(0):. 2021-04-30 [PMID: 33931727] (Bioassay, Mouse)
• HR Clark, C McKenney, NM Livingston, A Gershman, S Sajjan, IS Chan, AJ Ewald, W Timp, B Wu, A Singh, S Regot Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level Nature Communications, 2021-03-23;12(1):1836. 2021-03-23 [PMID: 33758175] (Bioassay, Human)
• H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler N4BP1 negatively regulates NF-&amp;kappaB by binding and inhibiting NEMO oligomerization Nature Communications, 2021-03-02;12(1):1379. 2021-03-02 [PMID: 33654074] (Bioassay, Mouse)
• L Micheli, M Vasarri, E Barletta, E Lucarini, C Ghelardini, D Degl'Innoc, L Di Cesare Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice Marine Drugs, 2021-01-21;19(2):. 2021-01-21 [PMID: 33494253] (Bioassay, Mouse)
• Y Yang, P Shen, T Yao, J Ma, Z Chen, J Zhu, Z Gong, S Shen, X Fang Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress Theranostics, 2021-01-01;11(4):1877-1900. 2021-01-01 [PMID: 33408787] (Bioassay, Mouse)
• LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana Gut-licensed IFN&amp;gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes Nature, 2021-01-06;0(0):. 2021-01-06 [PMID: 33408417] (Bioassay, Mouse)
• AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock Airway-Associated Macrophages in Homeostasis and Repair Cell Reports, 2020-12-29;33(13):108553. 2020-12-29 [PMID: 33378665] (Bioassay, Transgenic Mouse)
• X Yao, K Sun, S Yu, J Luo, J Guo, J Lin, G Wang, Z Guo, Y Ye, F Guo Chondrocyte ferroptosis contribute to the progression of osteoarthritis Journal of Orthopaedic Translation, 2020-12-17;27(0):33-43. 2020-12-17 [PMID: 33376672] (Cell Culture, Mouse)
• E Nummenmaa, M Hämäläinen, A Pemmari, LJ Moilanen, L Tuure, RM Nieminen, T Moilanen, K Vuolteenah, E Moilanen Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models International Journal of Molecular Sciences, 2020-12-23;22(1):. 2020-12-23 [PMID: 33374841] (Cell Culture, Tissue Culture, Mouse)
• S Shamdani, S Chantepie, C Flageollet, N Henni-Cheb, Y Jouan, F Eymard, E Hay, M Cohen-Sola, D Papy-Garci, X Chevalier, P Albanese Heparan sulfate functions are altered in the osteoarthritic cartilage Arthritis Research & Therapy, 2020-12-07;22(1):283. 2020-12-07 [PMID: 33287871] (Cell Culture, Mouse)
• S Lee, S Kim, HY Kang, HR Lim, Y Kwon, M Jo, YM Jeon, SR Kim, K Kim, CM Ha, S Lee, HJ Kim The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response J Neuroinflammation, 2020-10-14;17(1):299. 2020-10-14 [PMID: 33054766] (Bioassay, Mouse)
• F Namai, S Shigemori, T Ogita, T Sato, T Shimosato Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice Exp Mol Med, 2020-09-28;0(0):. 2020-09-28 [PMID: 32989233] (Bioassay, Mouse)
• V Grubiši?, JL McClain, DE Fried, I Grants, P Rajasekhar, E Csizmadia, OA Ajijola, RE Watson, DP Poole, SC Robson, FL Christofi, BD Gulbransen Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation Cell Rep, 2020-09-08;32(10):108100. 2020-09-08 [PMID: 32905782] (Bioassay, Mouse)
• MA Maqbool, L Pioger, AZ El Aabidin, N Karasu, AM Molitor, LTM Dao, G Charbonnie, F van Laethe, R Fenouil, F Koch, G Lacaud, I Gut, M Gut, S Amigorena, O Joffre, T Sexton, S Spicuglia, JC Andrau Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation Cell Rep, 2020-08-18;32(7):108048. 2020-08-18 [PMID: 32814051] (Bioassay, Cell Culture, Human, Mouse)
• I Mizoguchi, M Ohashi, H Hasegawa, Y Chiba, N Orii, S Inoue, C Kawana, M Xu, K Sudo, K Fujita, M Kuroda, SI Hashimoto, K Matsushima, T Yoshimoto EBV-induced gene 3 augments IL-23R&amp;alpha protein expression through a chaperone calnexin J. Clin. Invest., 2020-11-02;0(0):. 2020-11-02 [PMID: 32809973] (Bioassay, Mouse)
• J Jhun, HK Min, J Ryu, SY Lee, JG Ryu, JW Choi, HS Na, SY Lee, Y Jung, SJ Park, MS Park, B Kwon, GE Ji, ML Cho, SH Park Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells J Transl Med, 2020-08-15;18(1):317. 2020-08-15 [PMID: 32799896] (IHC, Mouse)
• K Kwiecien, P Brzoza, M Bak, P Majewski, I Skulimowsk, K Bednarczyk, J Cichy, M Kwitniewsk The methylation status of the chemerin promoter region located from -?252 to +?258�bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels Sci Rep, 2020-08-13;10(1):13702. 2020-08-13 [PMID: 32792625] (In Vivo, Bioassay, Mouse)
• M Liu, M Yan, H Lv, B Wang, X Lv, H Zhang, S Xiang, J Du, T Liu, Y Tian, X Zhang, F Zhou, T Cheng, Y Zhu, H Jiang, Y Cao, D Ai Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis Cell Rep, 2020-08-04;32(5):107990. 2020-08-04 [PMID: 32755583] (Bioassay, Mouse)
• H Ito, H Kimura, T Karasawa, S Hisata, A Sadatomo, Y Inoue, N Yamada, E Aizawa, E Hishida, R Kamata, T Komada, S Watanabe, T Kasahara, T Suzuki, H Horie, J Kitayama, N Sata, K Yamaji-Keg, M Takahashi NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury J. Immunol., 2020-07-29;0(0):. 2020-07-29 [PMID: 32727891] (Western Blot Control, Mouse)
• T Osthues, B Zimmer, V Rimola, K Klann, K Schilling, P Mathoor, C Angioni, A Weigert, G Geisslinge, C Münch, K Scholich, M Sisignano The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain Cells, 2020-07-21;9(7):. 2020-07-21 [PMID: 32708184] (Bioassay, Mouse)
• Y Dong, S Li, Y Lu, X Li, Y Liao, Z Peng, Y Li, L Hou, Z Yuan, J Cheng Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice J Neuroinflammation, 2020-07-07;17(1):205. 2020-07-07 [PMID: 32635937] (In Vivo, Mouse)
• J Kealy, C Murray, EW Griffin, AB Lopez-Rodr, D Healy, LS Tortorelli, JP Lowry, LO Watne, C Cunningham Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium J. Neurosci., 2020-06-08;0(0):. 2020-06-08 [PMID: 32513828] (In Vivo, Mouse, Transgenic Mouse)
• EM Hanschmann, SF Petry, S Eitner, CC Maresch, N Lingwal, CH Lillig, T Linn Paracrine regulation and improvement of &amp;beta-cell function by thioredoxin Redox Biol, 2020-05-16;34(0):101570. 2020-05-16 [PMID: 32473461] (Cell Culture, Mouse)
• L Monin, DS Ushakov, H Arnesen, N Bah, A Jandke, M Muñoz-Ruiz, J Carvalho, S Joseph, BC Almeida, MJ Green, E Nye, S Hatano, Y Yoshikai, M Curtis, H Carlsen, U Steinhoff, P Boysen, A Hayday gammadelta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Mucosal Immunol, 2020-05-29;0(0):. 2020-05-29 [PMID: 32472066] (Bioassay, Mouse)
• B Hou, Y Zhang, P Liang, Y He, B Peng, W Liu, S Han, J Yin, X He Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype Cell Death Dis, 2020-05-15;11(5):377. 2020-05-15 [PMID: 32415059] (Bioassay, Mouse)
• Y Huang, H Wang, Y Hao, H Lin, M Dong, J Ye, L Song, Y Wang, Q Li, B Shan, Y Jiang, H Li, Z Shao, G Kroemer, H Zhang, L Bai, T Jin, C Wang, Y Ma, Y Cai, C Ding, S Liu, Y Pan, W Jiang, R Zhou Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity Nat. Cell Biol., 2020-05-04;0(0):. 2020-05-04 [PMID: 32367047] (Bioassay, Mouse)
• S Ma, A Zhang, X Li, S Zhang, S Liu, H Zhao, S Wu, L Chen, C Ma, H Zhao MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1 Arthritis Res. Ther., 2020-05-01;22(1):99. 2020-05-01 [PMID: 32357909] (Bioassay, Mouse)
• SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang Noggin Inhibits IL-1&amp;beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis Cells, 2020-04-10;9(4):. 2020-04-10 [PMID: 32290085] (Cell Culture, Mouse)
• O Haidar, N O'Neill, CA Staunton, S Bavan, F O'Brien, S Zouggari, U Sharif, A Mobasheri, K Kumagai, R Barrett-Jo Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts Front Physiol, 2020-03-24;11(0):226. 2020-03-24 [PMID: 32265733] (Bioassay, Mouse)
• T Shimo, H Takebe, T Okui, Y Kunisada, S Ibaragi, K Obata, N Kurio, K Shamsoon, S Fujii, A Hosoya, K Irie, A Sasaki, M Iwamoto Expression and Role of IL-1&amp;beta Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing Int J Mol Sci, 2020-03-29;21(7):. 2020-03-29 [PMID: 32235405] (Bioassay, Mouse)
• HS Son, J Lee, HI Lee, N Kim, YJ Jo, GR Lee, SE Hong, M Kwon, NY Kim, HJ Kim, JH Park, SY Lee, W Jeong Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 &amp;beta expression Acta Pharm Sin B, 2019-11-08;10(3):462-474. 2019-11-08 [PMID: 32140392] (Cell Culture, Mouse)
• H Li, X Ding, R Terkeltaub, H Lin, Y Zhang, B Zhou, K He, K Li, Z Liu, J Wei, Y Yang, H Xie, C Zeng, G Lei Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior Arthritis Res. Ther., 2020-02-22;22(1):34. 2020-02-22 [PMID: 32087740] (Cell Culture, Mouse)
• MA Wheeler, IC Clark, EC Tjon, Z Li, SEJ Zandee, CP Couturier, BR Watson, G Scalisi, S Alkwai, V Rothhammer, A Rotem, JA Heyman, S Thaploo, LM Sanmarco, J Ragoussis, DA Weitz, K Petrecca, JR Moffitt, B Becher, JP Antel, A Prat, FJ Quintana MAFG-driven astrocytes promote CNS inflammation Nature, 2020-02-12;0(0):. 2020-02-12 [PMID: 32051591] (Cell Culture, Mouse)
• FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair Nat Commun, 2020-01-30;11(1):600. 2020-01-30 [PMID: 32001677] (Bioassay, Mouse)
• M Ichii, K Oritani, J Toda, H Saito, H Shi, H Shibayama, D Motooka, Y Kitai, R Muromoto, JI Kashiwakur, K Saitoh, D Okuzaki, T Matsuda, Y Kanakura Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress Haematologica, 2021-02-01;0(0):. 2021-02-01 [PMID: 31974192] (Cell Culture, Mouse)
• JH Jang, DH Kim, JM Lim, JW Lee, SJ Jeong, KP Kim, YJ Surh Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1&amp;beta Production Cancer Res, 2020-01-22;80(6):1342-1356. 2020-01-22 [PMID: 31969374] (Bioassay, Mouse)
• C van de Wet, R Aboushoush, AM Manuel, SB Chia, C Erickson, MB MacPherson, JL van der Ve, V Anathy, AE Dixon, CG Irvin, ME Poynter, A van der Vl, EFM Wouters, NL Reynaert, YMW Janssen-He Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease J. Immunol., 2020-01-10;204(4):763-774. 2020-01-10 [PMID: 31924651] (Cell Culture, In Vivo, Mouse)
• P Pan, Q Zhang, W Liu, W Wang, Z Yu, Z Lao, W Zhang, M Shen, P Wan, F Xiao, MA Shereen, W Zhang, Q Tan, Y Liu, X Liu, K Wu, Y Liu, G Li, J Wu Dengue Virus Infection Activates Interleukin-1beta to Induce Tissue Injury and Vascular Leakage Front Microbiol, 2019-11-22;10(0):2637. 2019-11-22 [PMID: 31824450] (In Vivo, Mouse)
• HG Lee, LK Kim, JM Choi NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17 Mol Ther Methods Clin Dev, 2019-10-23;16(0):32-41. 2019-10-23 [PMID: 31737742] (Cell Culture, Mouse)
• D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf Cell Rep, 2019-10-29;29(5):1203-1220.e7. 2019-10-29 [PMID: 31665634] (Bioassay, Mouse)
• S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing Nature, 2019-10-23;574(7779):553-558. 2019-10-23 [PMID: 31645721] (Cell Culture, Mouse)
• DX Ji, LH Yamashiro, KJ Chen, N Mukaida, I Kramnik, KH Darwin, RE Vance Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra Nat Microbiol, 2019-10-14;0(0):. 2019-10-14 [PMID: 31611644] (Bioassay, Mouse)
• J Yu, H Zhu, S Taheri, W Mondy, L Bonilha, GS Magwood, D Lackland, RJ Adams, MS Kindy Serum amyloid A-mediated inflammasome activation of microglial cells in cerebral ischemia J. Neurosci., 2019-10-14;0(0):. 2019-10-14 [PMID: 31611307] (ELISA Standard, Mouse)
• NW Zammit, SN Walters, KL Seeberger, PJ O'Connell, GS Korbutt, ST Grey A20 as an immune tolerance factor can determine islet transplant outcomes JCI Insight, 2019-11-01;4(21):. 2019-11-01 [PMID: 31581152] (Bioassay, Mouse)
• M Bensellam, JY Chan, K Lee, MV Joglekar, AA Hardikar, T Loudovaris, HE Thomas, JC Jonas, DR Laybutt Phlda3 regulates beta cell survival during stress Sci Rep, 2019-09-06;9(1):12827. 2019-09-06 [PMID: 31492921] (Bioassay, Mouse)
• TY Chan, CL Yen, YF Huang, PC Lo, PA Nigrovic, CY Cheng, WZ Wang, SY Wu, CC Shieh Increased ILC3s associated with higher levels of IL-1? aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase Eur. J. Immunol., 2019-08-06;0(0):. 2019-08-06 [PMID: 31350760] (Cell Culture, Mouse)
• G Chen, X Luo, W Wang, Y Wang, F Zhu, W Wang Interleukin-1? Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway Front Cell Neurosci, 2019-07-09;13(0):304. 2019-07-09 [PMID: 31338026] (Tissue Culture, Rat)
• S Darkwah, N Nago, MG Appiah, PK Myint, E Kawamoto, M Shimaoka, EJ Park Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis Biomedicines, 2019-07-18;7(3):. 2019-07-18 [PMID: 31323786] (Bioassay, Mouse)
• C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt Bioorg. Chem., 2019-06-21;90(0):103077. 2019-06-21 [PMID: 31323598] (Cell Culture, Mouse)
• X Zhou, H Chen, F Wei, Q Zhao, Q Su, J Liang, M Yin, X Tian, Z Liu, B Yu, C Bai, X He, Z Huang 3?-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation J Immunol Res, 2019-05-22;2019(0):2431617. 2019-05-22 [PMID: 31240232] (Cell Culture, Mouse)
• L Todd, I Palazzo, L Suarez, X Liu, L Volkov, TV Hoang, WA Campbell, S Blackshaw, N Quan, AJ Fischer Reactive microglia and IL1?/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina J Neuroinflammation, 2019-06-06;16(1):118. 2019-06-06 [PMID: 31170999] (In Vivo, Mouse, Transgenic Mouse)
• K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death J. Immunol., 2019-05-31;0(0):. 2019-05-31 [PMID: 31152078] (Bioassay, Mouse)
• A Lalwani, J Warren, D Liuwantara, WJ Hawthorne, PJ O'Connell, FJ Gonzalez, RA Stokes, J Chen, DR Laybutt, ME Craig, MM Swarbrick, C King, JE Gunton ? Cell Hypoxia-Inducible Factor-1? Is Required for the Prevention of Type 1 Diabetes Cell Rep, 2019-05-21;27(8):2370-2384.e6. 2019-05-21 [PMID: 31116982] (Bioassay, Mouse)
• DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity Exp. Mol. Med., 2019-04-15;51(4):41. 2019-04-15 [PMID: 30988419] (Bioassay, Mouse)
• OM Finucane, J Sugrue, A Rubio-Arai, MV Guillot-Se, MA Lynch The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1?-dependent manner in macrophages Sci Rep, 2019-03-11;9(1):4034. 2019-03-11 [PMID: 30858427] (Bioassay, Mouse)
• Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development EBioMedicine, 2019-03-01;0(0):. 2019-03-01 [PMID: 30827928] (Cell Culture, Mouse)
• S Morita-Tak, K Nakahara, S Hasegawa-I, A Isonishi, K Tatsumi, H Okuda, T Tanaka, M Kitabatake, T Ito, A Wanaka Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance J Neuroinflammation, 2019-02-14;16(1):39. 2019-02-14 [PMID: 30764851] (Mouse)
• JD Glenn, C Liu, KA Whartenby Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung J. Leukoc. Biol., 2019-02-14;0(0):. 2019-02-14 [PMID: 30762897] (Bioassay, Mouse)
• HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Mouse)
• W Li, S Zhao, H Yang, C Zhang, Q Kang, J Deng, Y Xu, Y Ding, S Li Potential Novel Prediction of TMJ-OA: MiR-140-5p Regulates Inflammation Through Smad/TGF-? Signaling Front Pharmacol, 2019-01-23;10(0):15. 2019-01-23 [PMID: 30728776] (Bioassay, Mouse)
• K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)
• Y Saeki, K Ishiyama, N Ishida, Y Tanaka, H Ohdan Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation Sci Rep, 2019-01-31;9(1):1022. 2019-01-31 [PMID: 30705364] (Bioassay, Mouse)
• S Das, D Bar-Sagi BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis Oncogene, 2019-01-11;0(0):. 2019-01-11 [PMID: 30635655] (Cell Culture, Mouse)
• M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018-12-26;25(13):3733-3749.e8. 2018-12-26 [PMID: 30590045] (Bioassay, Mouse)
• F Dou, X Chu, B Zhang, L Liang, G Lu, J Ding, S Chen EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-?B signaling pathway Mol Brain, 2018-12-18;11(1):75. 2018-12-18 [PMID: 30563578] (ELISA (Standard), Mouse)
• R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4 Oncogene, 2018-12-05;0(0):. 2018-12-05 [PMID: 30518876] (Bioassay, Mouse)
• E Engelowski, NF Modares, S Gorressen, P Bouvain, D Semmler, C Alter, Z Ding, U Flögel, J Schrader, H Xu, PA Lang, J Fischer, DM Floss, J Scheller IL-23R Signaling Plays No Role in Myocardial Infarction Sci Rep, 2018-11-20;8(1):17078. 2018-11-20 [PMID: 30459442] (Bioassay, Mouse)
• F Mathies, N Steffens, D Kleinschmi, F Stuhlmann, FJ Huber, U Roy, T Meyer, M Luetgehetm, M von Peters, O Seiz, J Herkel, C Schramm, RA Flavell, N Gagliani, C Krebs, U Panzer, Z Abdullah, T Strowig, T Bedke, S Huber Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells J. Immunol., 2018-11-16;0(0):. 2018-11-16 [PMID: 30446566] (Differentiation, Differentiation, Mouse)
• KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism Cell Death Dis, 2018-11-13;9(11):1130. 2018-11-13 [PMID: 30425241] (Bioassay, Mouse)
• CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses PLoS Pathog., 2018-10-26;14(10):e1007406. 2018-10-26 [PMID: 30365535] (Bioassay, Mouse)
• JT Benjamin, DJ Moore, C Bennett, R van der Me, A Royce, R Loveland, JL Wynn Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality J. Immunol., 2018-10-10;0(0):. 2018-10-10 [PMID: 30305325] (In Vivo, Mouse)
• HY Nam, JH Nam, G Yoon, JY Lee, Y Nam, HJ Kang, HJ Cho, J Kim, HS Hoe Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice J Neuroinflammation, 2018-09-19;15(1):271. 2018-09-19 [PMID: 30231870] (ELISA (Standard), Mouse)
• DB Ballak, S Li, G Cavalli, JL Stahl, IW Tengesdal, JA van Diepen, V Kluck, B Swartzwelt, T Azam, CJ Tack, R Stienstra, T Mandrup-Po, DR Seals, CA Dinarello Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue J. Biol. Chem., 2018-07-13;0(0):. 2018-07-13 [PMID: 30006351] (Bioassay, Mouse)
• CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice Stem Cell Res Ther, 2018-07-04;9(1):183. 2018-07-04 [PMID: 29973247] (Bioassay, Mouse)
• JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh Induction of innate immune memory via microRNA targeting of chromatin remodelling factors Nature, 2018-06-27;559(7712):114-119. 2018-06-27 [PMID: 29950719] (Bioassay, Mouse)
• DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms Mol. Psychiatry, 2018-06-06;24(10):1533-1548. 2018-06-06 [PMID: 29875474] (In Vivo, Mouse)
• HM Hsiao, R Fernandez, S Tanaka, W Li, JH Spahn, S Chiu, M Akbarpour, D Ruiz-Perez, Q Wu, C Turam, D Scozzi, T Takahashi, HP Luehmann, V Puri, GRS Budinger, AS Krupnick, AV Misharin, KJ Lavine, Y Liu, AE Gelman, A Bharat, D Kreisel Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1? J. Clin. Invest., 2018-05-21;128(7):2833-2847. 2018-05-21 [PMID: 29781811] (Bioassay, Mouse)
• B Caughron, Y Yang, MRI Young Role of IL-23 signaling in the progression of premalignant oral lesions to cancer PLoS ONE, 2018-04-17;13(4):e0196034. 2018-04-17 [PMID: 29664967] (Bioassay, Mouse)
• JP Ingram, S Tursi, T Zhang, W Guo, C Yin, M A Wynosky-, J van der He, KQ Cai, M Yamamoto, BB Finlay, IE Brodsky, SI Grivenniko, Ç Tükel, S Balachandr A Nonpyroptotic IFN-?-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo J. Immunol., 2018-04-13;0(0):. 2018-04-13 [PMID: 29654208] (Bioassay, Mouse)
• H Kuwata, C Yuzurihara, N Kinoshita, Y Taki, Y Ikegami, S Washio, Y Hirakawa, E Yoda, T Aiuchi, H Itabe, Y Nakatani, S Hara The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts FEBS J., 2018-04-18;0(0):. 2018-04-18 [PMID: 29637744] (Bioassay, Rat)
• G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 2018-03-20;48(3):556-569.e7. 2018-03-20 [PMID: 29562202] (Bioassay, Mouse)
• HV Lin, J Wang, J Wang, W Li, X Wang, JT Alston, MK Thomas, DA Briere, SK Syed, AM Efanov GPR142 prompts glucagon-like Peptide-1 release from islets to improve ? cell function Mol Metab, 2018-02-23;0(0):. 2018-02-23 [PMID: 29506910] (Bioassay, Mouse)
• AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection J. Exp. Med., 2018-02-28;0(0):. 2018-02-28 [PMID: 29490936] (Bioassay, Mouse)
• CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation Elife, 2018-02-22;7(0):. 2018-02-22 [PMID: 29469805] (In Vivo, Mouse)
• QH Wang, SW Lv, YY Guo, JX Duan, SY Dong, QS Wang, FM Yu, H Su, HX Kuang Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro Evid Based Complement Alternat Med, 2017-12-31;2017(0):8134321. 2017-12-31 [PMID: 29456573] (Bioassay, Mouse)
• W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 2018-02-09;0(0):. 2018-02-09 [PMID: 29432809] (Cell Culture, Mouse)
• A Song, L Zhu, G Gorantla, O Berdysz, SA Amici, M Guerau-de-, KM Madalena, JK Lerch, X Liu, N Quan Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells Sci Rep, 2018-01-15;8(1):723. 2018-01-15 [PMID: 29335509] (In Vivo, Mouse)
• A Mancini, M Tantucci, P Mazzocchet, A de Iure, V Durante, L Macchioni, C Giampà, A Alvino, L Gaetani, C Costa, A Tozzi, P Calabresi, M Di Filippo Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis Neurobiol. Dis., 2018-01-09;0(0):. 2018-01-09 [PMID: 29325869] (Bioassay, Mouse)
• H Makino, S Seki, Y Yahara, S Shiozawa, Y Aikawa, H Motomura, M Nogami, K Watanabe, T Sainoh, H Ito, N Tsumaki, Y Kawaguchi, M Yamazaki, T Kimura A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain Sci Rep, 2017-12-05;7(1):16983. 2017-12-05 [PMID: 29208967] (Bioassay, Mouse)
• A Muschaweck, F Petermann, T Korn IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855314] (Bioassay, Mouse)
• K Kamizaki, R Doi, M Hayashi, T Saji, M Kanagawa, T Toda, SI Fukada, HH Ho, ME Greenberg, M Endo, Y Minami The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle J. Biol. Chem., 2017-08-08;0(0):. 2017-08-08 [PMID: 28790171] (Bioassay, Mouse)
• TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath The Role of Inflammation in ?-cell Dedifferentiation Sci Rep, 2017-07-24;7(1):6285. 2017-07-24 [PMID: 28740254] (Bioassay, Mouse)
• Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype Mol Metab, 2017-05-06;6(7):725-736. 2017-05-06 [PMID: 28702328] (Bioassay, Human)
• C Wang, CX Xu, Y Alippe, C Qu, J Xiao, E Schipani, R Civitelli, Y Abu-Amer, G Mbalaviele Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells Sci Rep, 2017-07-07;7(1):4880. 2017-07-07 [PMID: 28687790] (Bioassay, Mouse)
• SY Nam, KY Kim, MH Kim, JB Jang, SY Rah, HJ Chae, JM Lee, HM Kim, HJ Jeong Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan Pharm Biol, 2017-12-01;55(1):1856-1862. 2017-12-01 [PMID: 28614972] (ELISA (Standard), Mouse)
• IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells Eur. J. Immunol., 2017-06-29;0(0):. 2017-06-29 [PMID: 28598502] (Bioassay, Mouse)
• Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539431] (Bioassay, Mouse)
• AM Yang, T Inamine, K Hochrath, P Chen, L Wang, C Llorente, S Bluemel, P Hartmann, J Xu, Y Koyama, T Kisseleva, MG Torralba, K Moncera, K Beeri, CS Chen, K Freese, C Hellerbran, SM Lee, HM Hoffman, WZ Mehal, G Garcia-Tsa, EA Mutlu, A Keshavarzi, GD Brown, SB Ho, R Bataller, P Stärkel, DE Fouts, B Schnabl Intestinal fungi contribute to development of alcoholic liver disease J. Clin. Invest., 2017-05-22;0(0):. 2017-05-22 [PMID: 28530644] (Bioassay, Mouse)
• MG Ledesma-Co, N Adán, G Ortiz, M Solís-Guti, F López-Barr, G Martínez d, C Clapp Prolactin blocks the expression of receptor activator of nuclear factor ?B ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis Arthritis Res. Ther., 2017-05-15;19(1):93. 2017-05-15 [PMID: 28506283] (In Vivo, Mouse)
• CX Yi, M Walter, Y Gao, S Pitra, B Legutko, S Kälin, C Layritz, C García-Các, M Bielohuby, M Bidlingmai, SC Woods, A Ghanem, KK Conzelmann, JE Stern, M Jastroch, MH Tschöp TNF? drives mitochondrial stress in POMC neurons in obesity Nat Commun, 2017-05-10;8(0):15143. 2017-05-10 [PMID: 28489068] (Bioassay, Mouse)
• F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria PLoS Pathog., 2017-04-27;13(4):e1006322. 2017-04-27 [PMID: 28448579] (Bioassay, Mouse)
• K Wang, L Ye, H Lu, H Chen, Y Zhang, Y Huang, JC Zheng TNF-? promotes extracellular vesicle release in mouse astrocytes through glutaminase J Neuroinflammation, 2017-04-20;14(1):87. 2017-04-20 [PMID: 28427419] (Bioassay, Mouse)
• MX Li, HL Zheng, Y Luo, JG He, W Wang, J Han, L Zhang, X Wang, L Ni, HY Zhou, ZL Hu, PF Wu, Y Jin, LH Long, H Zhang, G Hu, JG Chen, F Wang Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs Mol. Psychiatry, 2017-04-18;0(0):. 2017-04-18 [PMID: 28416811] (In Vivo, Mouse)
• G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1 J. Exp. Med., 2017-04-11;0(0):. 2017-04-11 [PMID: 28400474] (Bioassay, Mouse)
• D Sireesh, MR Ganesh, U Dhamodhara, M Sakthivadi, S Sivasubram, P Gunasekara, KM Ramkumar Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade J. Nutr. Biochem, 2017-03-06;44(0):11-21. 2017-03-06 [PMID: 28343084] (Bioassay, Mouse)
• CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet IL-1? is an innate immune sensor of microbial proteolysis Sci Immunol, 2016-08-19;1(2):. 2016-08-19 [PMID: 28331908] (Bioassay, Mouse)
• MC Lee, JA McCubbin, AD Christense, DP Poole, P Rajasekhar, T Lieu, NW Bunnett, S Garcia-Car, A Erickson, SM Brierley, R Saleh, A Achuthan, AJ Fleetwood, RL Anderson, JA Hamilton, AD Cook G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease J. Immunol, 2017-03-20;0(0):. 2017-03-20 [PMID: 28320832] (In Vivo, Mouse)
• F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4 PLoS ONE, 2017-03-09;12(3):e0172738. 2017-03-09 [PMID: 28278201] (Bioassay, Mouse)
• L Di Candia, E Gomez, E Venereau, L Chachi, D Kaur, ME Bianchi, RA Challiss, CE Brightling, RM Saunders HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4 J. Allergy Clin. Immunol, 2017-03-01;0(0):. 2017-03-01 [PMID: 28259445] (Bioassay, Mouse)
• W Huang, W Fan, Y Wang, D Han, X Li, S Li, C Li, B Xu, Y Huang, X Fu, F Cao Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway Cell Death Discov, 2017-02-27;3(0):16097. 2017-02-27 [PMID: 28250969] (Bioassay, Mouse)
• L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis J. Immunol, 2017-02-27;0(0):. 2017-02-27 [PMID: 28242647] (Bioassay, Mouse)
• S Choi, S You, D Kim, SY Choi, HM Kwon, HS Kim, D Hwang, YJ Park, CS Cho, WU Kim Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis J. Clin. Invest, 2017-02-13;127(3):954-969. 2017-02-13 [PMID: 28192374] (In Vivo, Mouse)
• Richard P Ciavarra Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep J. Neuroimmunol, 2016-12-29;0(0):. 2016-12-29 [PMID: 28041664] (In Vivo, Mouse)
• NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis Sci Rep, 2016-12-14;6(0):39075. 2016-12-14 [PMID: 27966619] (In Vivo, Mouse)
• Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 2016-12-01;6(0):37977. 2016-12-01 [PMID: 27905482] (Bioassay, Mouse)
• Stephen J Galli Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis J. Clin. Invest., 2016-11-07;0(0):. 2016-11-07 [PMID: 27820702] (Bioassay, Mouse)
• Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels PLoS ONE, 2016-09-23;11(9):e0163735. 2016-09-23 [PMID: 27662193] (Bioassay, Mouse)
• A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury J Immunol, 2016-08-24;0(0):. 2016-08-24 [PMID: 27559050] (Bioassay, Mouse)
• TLR4-Upregulated IL-1? and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism Sci Rep, 2016-08-16;6(0):31663. 2016-08-16 [PMID: 27526865] (Bioassay, In Vivo, Mouse)
• Epidermal RAF prevents allergic skin disease Elife, 2016-07-19;5(0):. 2016-07-19 [PMID: 27431613] (Bioassay, Human, Mouse)
• Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence Nature, 2016-07-13;535(7612):440-3. 2016-07-13 [PMID: 27409807] (Bioassay, Mouse)
• Marie-Laure Michel SLAM-associated protein favours the development of iNKT2 over iNKT17 cells Eur J Immunol, 2016-07-22;0(0):. 2016-07-22 [PMID: 27338553] (Bioassay, Mouse)
• LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses J. Biol. Chem., 2016-05-23;291(30):15830-40. 2016-05-23 [PMID: 27226638] (Bioassay, Mouse)
• Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells J Immunol, 2016-04-22;196(11):4731-8. 2016-04-22 [PMID: 27183613] (Bioassay, Mouse)
• Platelets Guide Leukocytes to Their Sites of Extravasation PLoS Biol, 2016-05-06;14(5):e1002459. 2016-05-06 [PMID: 27152726] (In Vivo, Mouse)
• Shweta Pasi Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response J Biol Chem, 2016-03-28;291(23):12358-69. 2016-03-28 [PMID: 27022030] (Bioassay, Mouse)
• Swaroop S, Sengupta N, Suryawanshi A, Adlakha Y, Basu A HSP60 plays a regulatory role in IL-1beta-induced microglial inflammation via TLR4-p38 MAPK axis. J Neuroinflammation, 2016-02-02;13(1):27. 2016-02-02 [PMID: 26838598] (Bioassay, Mouse)
• Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, Shu H TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms. J Immunol, 2015-09-21;195(9):4415-25. 2015-09-21 [PMID: 26392463] (Bioassay, Mouse)
• Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med, 2015-03-16;21(4):363-72. 2015-03-16 [PMID: 25774850] (Bioassay, Mouse)
• Liu X, Yamashita T, Chen Q, Belevych N, Mckim D, Tarr A, Coppola V, Nath N, Nemeth D, Syed Z, Sheridan J, Godbout J, Zuo J, Quan N Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. J Neurosci, 2015-02-18;35(7):2860-70. 2015-02-18 [PMID: 25698726] (In Vivo, Mouse)
• Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection. J Immunol, 2015-02-18;194(6):2888-98. 2015-02-18 [PMID: 25694610] (Bioassay, Mouse)
• Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. J Immunol, 2015-02-11;194(6):2522-30. 2015-02-11 [PMID: 25672751] (Bioassay, Mouse)
• Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol, 2015-02-02;16(3):286-95. 2015-02-02 [PMID: 25642823] (Bioassay, Mouse)
• Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. MBio, 2015-01-27;6(1):. 2015-01-27 [PMID: 25626905] (Bioassay, Human, Mouse)
• Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. J Neurosci, 2015-01-07;35(1):4-20. 2015-01-07 [PMID: 25568099] (Bioassay, Mouse)
• Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. Stem Cell Reports, 2014-12-31;4(1):25-36. 2014-12-31 [PMID: 25556566] (Bioassay, Mouse)
• Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I Interleukin-1beta enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes. PLoS ONE, 2014-12-31;9(12):e115603. 2014-12-31 [PMID: 25551609] (Bioassay, Mouse)
• Jin , Shijie, Sonobe , Yoshifum, Kawanokuchi , Jun, Horiuchi , Hiroshi, Cheng , Yi, Wang , Yue, Mizuno , Tetsuya, Takeuchi , Hideyuki, Suzumura , Akio Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. PLoS ONE, 2014-12-23;9(12):e115981. 2014-12-23 [PMID: 25535736] (Bioassay, Mouse)
• Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, Higgins S, Mills K A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine. Mucosal Immunol, 2014-10-15;8(3):607-17. 2014-10-15 [PMID: 25315966] (Bioassay, Mouse)
• Blum B, Roose A, Barrandon O, Maehr R, Arvanites A, Davidow L, Davis J, Peterson Q, Rubin L, Melton D Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway. Elife, 2014-09-16;3(0):e02809. 2014-09-16 [PMID: 25233132] (Bioassay, Mouse)
• Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 2014-07-29;211(9):1807-19. 2014-07-29 [PMID: 25073792] (Bioassay, Mouse)
• Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2alpha. J Immunol, 2014-07-02;193(3):1459-67. 2014-07-02 [PMID: 24990083] (Bioassay, Mouse)
• Ingham V, Williams A, Bate C Glimepiride reduces CD14 expression and cytokine secretion from macrophages. J Neuroinflammation, 2014-06-21;11(0):115. 2014-06-21 [PMID: 24952384] (ELISA (Standard), Mouse)
• Glenn J, Smith M, Calabresi P, Whartenby K Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis. Stem Cells, 2014-10-01;32(10):2744-55. 2014-10-01 [PMID: 24911892] (Bioassay, Mouse)
• Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, Leemans J A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. Am J Pathol, 2014-05-11;184(7):2013-22. 2014-05-11 [PMID: 24823805] (Western Blot, Mouse)
• Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain. J Biol Chem, 2014-04-22;289(22):15621-30. 2014-04-22 [PMID: 24755218] (Bioassay, Degradation, Bacteria - Porphyromonas gingivalis, Mouse)
• Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, Iwai K IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex. J Immunol, 2014-03-14;192(8):3793-804. 2014-03-14 [PMID: 24634492] (Bioassay, Mouse)
• Hahn W, Kuzmicic J, Burrill J, Donoghue M, Foncea R, Jensen M, Lavandero S, Arriaga E, Bernlohr D Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab, 2014-03-04;306(9):E1033-45. 2014-03-04 [PMID: 24595304] (Bioassay, Mouse)
• Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med, 2013-12-22;20(1):62-8. 2013-12-22 [PMID: 24362934] (Bioassay, Mouse)
• Lee S, Lee K, Yi S, Kook S, Lee J Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production. PLoS ONE, 2013-12-04;8(12):e80873. 2013-12-04 [PMID: 24324641] (Cell Culture, Mouse)
• Halai , Krishma, Whiteford , James, Ma , Bin, Nourshargh , Sussan, Woodfin , Abigail ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo. J Cell Sci, 2013-12-06;127(0):620-9. 2013-12-06 [PMID: 24317296] (In Vivo, Mouse)
• Zehendner , Christop, Wedler , Hannah E, Luhmann , Heiko J A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex. PLoS ONE, 2013-11-21;8(11):e81637. 2013-11-21 [PMID: 24278454] (Bioassay, Mouse)
• Jana M, Mondal S, Jana A, Pahan K Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis. Immunology, 2014-04-01;141(4):549-63. 2014-04-01 [PMID: 24224652] (Bioassay, Mouse)
• Moon C, VanDussen K, Miyoshi H, Stappenbeck T Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol, 2013-11-13;7(4):818-28. 2013-11-13 [PMID: 24220295] (Bioassay, Mouse)
• Valcarcel M, Carrascal T, Crende O, Vidal-Vanaclocha F IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors. J Invest Dermatol, 2013-08-12;134(2):470-80. 2013-08-12 [PMID: 23938462] (Bioassay, Mouse)
• Steelman A, Smith R, Welsh C, Li J Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis. J Biol Chem, 2013-07-08;288(33):23776-87. 2013-07-08 [PMID: 23836896] (Bioassay, Mouse)
• Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PLoS ONE, 2013-04-02;8(4):e60226. 2013-04-02 [PMID: 23565202] (Bioassay, Mouse)
• Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol, 2013-03-13;190(8):4196-204. 2013-03-13 [PMID: 23487424] (Bioassay, Mouse)
• Song J, Wu C, Zhang X, Sorokin L In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1beta-induced peritonitis. J Immunol, 2012-12-07;190(1):401-10. 2012-12-07 [PMID: 23225890] (In Vivo, Mouse)
• Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med, 2012-12-02;19(1):57-64. 2012-12-02 [PMID: 23202296] (Bioassay, Mouse)
• Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Bioassay, Mouse)
• Flanagan K, Fitzgerald K, Baker J Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. PLoS ONE, 2012-07-06;7(7):e40443. 2012-07-06 [PMID: 22792325] (Bioassay, Mouse)
• Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)
• Zhao H, Zhao X, Cao X, Wu G Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice. Immun Ageing, 2012-05-28;9(1):12. 2012-05-28 [PMID: 22640633] (Bioassay, Mouse)
• Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J. Exp. Med., 2012-05-21;209(6):1219-34. 2012-05-21 [PMID: 22615129] (In Vivo, Mouse)
• Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression. Mol. Endocrinol., 2012-04-02;26(5):775-85. 2012-04-02 [PMID: 22474109] (Bioassay, Mouse)
• Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J. Clin. Invest., 2012-04-02;122(5):1758-63. 2012-04-02 [PMID: 22466650] (In Vivo, Mouse)
• Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection. Infect. Immun., 2011-10-24;80(1):398-409. 2011-10-24 [PMID: 22025517] (In Vivo, Mouse)
• El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Bioassay, Mouse)
• Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J. Exp. Med., 2011-03-07;208(3):491-503. 2011-03-07 [PMID: 21383056] (Bioassay, Mouse)
• Sanchez-Alavez M, Osborn O, Tabarean IV Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors. J. Biol. Chem., 2011-02-17;286(17):14983-90. 2011-02-17 [PMID: 21330367] (In Vivo, Mouse)
• Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases. MAbs, 2011-01-01;3(1):49-60. 2011-01-01 [PMID: 21048425] (Binding Assay, Mouse)
• Petri B, Kaur J, Long EM, Li H, Parsons SA, Butz S, Phillipson M, Vestweber D, Patel KD, Robbins SM, Kubes P Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo. Blood, 2010-10-28;117(3):942-52. 2010-10-28 [PMID: 21030556] (In Vivo, Mouse)
• Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM Tim3 binding to galectin-9 stimulates antimicrobial immunity. J. Exp. Med., 2010-10-11;207(11):2343-54. 2010-10-11 [PMID: 20937702] (Bioassay, Mouse)
• Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)
• Chou RC, Kim ND, Sadik CD Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity, 2010-08-27;33(2):266-78. 2010-08-27 [PMID: 20727790] (Bioassay, In Vivo, Mouse)
• Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J. Clin. Invest., 2010-04-01;120(5):1762-73. 2010-04-01 [PMID: 20364087] (Bioassay, Mouse)
• Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130. Endocrinology, 2009-12-16;151(2):606-16. 2009-12-16 [PMID: 20016025] (In Vivo, Mouse)
• Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J. Immunol., 2009-12-15;183(12):7890-7. 2009-12-15 [PMID: 19933859] (Bioassay, Mouse)
• Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept. Brain Behav. Immun., 2009-10-25;24(5):747-58. 2009-10-25 [PMID: 19861157] (In Vivo, Mouse)
• Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway. J. Immunol., 2009-10-19;183(10):6135-44. 2009-10-19 [PMID: 19841165] (Bioassay, Mouse)
• Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat. Med., 2009-09-20;15(10):1170-8. 2009-09-20 [PMID: 19767732] (Bioassay, Mouse)
• Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J. Immunol., 2009-08-28;183(6):4021-30. 2009-08-28 [PMID: 19717513] (Western Blot)
• Mizutani N, Nabe T, Yoshino S Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. J. Immunol., 2009-08-14;183(6):4039-46. 2009-08-14 [PMID: 19684087] (In Vivo, Mouse)
• Koziczak-Holbro M, Littlewood-Evans A, Pollinger B, Kovarik J, Dawson J, Zenke G, Burkhart C, Muller M, Gram H The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation. Arthritis Rheum., 2009-06-01;60(6):1661-71. 2009-06-01 [PMID: 19479877] (In Vivo, Mouse)
• Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2. Endocrinology, 2008-11-20;150(4):1850-60. 2008-11-20 [PMID: 19022895] (In Vivo, Mouse)
• Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008-11-01;58(11):3510-9. 2008-11-01 [PMID: 18975342] (Bioassay, Mouse)
• Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology, 2008-06-26;149(10):4837-45. 2008-06-26 [PMID: 18583425] (In Vivo, Mouse)
• Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT Induction of IL-33 expression and activity in central nervous system glia. J. Leukoc. Biol., 2008-06-13;84(3):631-43. 2008-06-13 [PMID: 18552204] (Bioassay, Mouse)
• Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am. J. Pathol., 2008-06-05;173(1):57-67. 2008-06-05 [PMID: 18535174] (Bioassay, Mouse)
• Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model. Cell. Immunol., 2008-05-20;251(2):78-85. 2008-05-20 [PMID: 18495099] (In Vivo, Mouse)
• Olivadoti MD, Opp MR Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice. Neuroscience, 2008-02-19;153(1):338-48. 2008-02-19 [PMID: 18367337] (In Vivo, Mouse)
• Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH, Lynch MA IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8. J. Neurochem., 2008-02-18;105(5):1960-9. 2008-02-18 [PMID: 18284608] (In Vivo, Mouse)
• Antonopoulos C, Cumberbatch M, Mee JB, Dearman RJ, Wei XQ, Liew FY, Kimber I, Groves RW IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J. Leukoc. Biol., 2007-11-05;83(2):361-7. 2007-11-05 [PMID: 17984289] (In Vivo, Mouse)
• Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J Cell surface 4-1BBL mediates sequential signaling pathways &apos;downstream&apos; of TLR and is required for sustained TNF production in macrophages. Nat. Immunol., 2007-05-13;8(6):601-9. 2007-05-13 [PMID: 17496895] (Bioassay, Mouse)
• Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H Protection of CD8+ T cells from activation-induced cell death by IL-18. J. Leukoc. Biol., 2007-03-30;82(1):142-51. 2007-03-30 [PMID: 17400610] (Bioassay, Mouse)
• Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm. Res., 2006-11-01;55(11):457-64. 2006-11-01 [PMID: 17122962] (ELISA (Standard))
• Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev., 2006-09-15;20(18):2527-38. 2006-09-15 [PMID: 16980582] (Bioassay, Mouse)
• Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model. J. Mol. Cell. Cardiol., 2006-09-11;41(5):885-92. 2006-09-11 [PMID: 16963076] (Bioassay, Mouse)
• Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA (Standard))
• Vickers TA, Zhang H, Graham MJ, Lemonidis KM, Zhao C, Dean NM Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2&apos;-O-methoxyethyl-modified oligonucleotide. J. Immunol., 2006-03-15;176(6):3652-61. 2006-03-15 [PMID: 16517734] (In Vivo, Mouse)
• Mendez MP, Morris SB, Wilcoxen S, Greeson E, Moore B, Paine R Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol., 2005-12-22;290(5):L962-70. 2005-12-22 [PMID: 16373671] (Bioassay, Mouse)
• Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice. Immunol. Lett., 2005-09-26;102(2):158-68. 2005-09-26 [PMID: 16216339] (In Vivo, Mouse)
• Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA (Standard))
• Ellaban E, Bolgos G, Remick D Selective macrophage suppression during sepsis. Cell. Immunol., 2005-02-26;231(1):103-11. 2005-02-26 [PMID: 15919375] (ELISA (Standard))
• Perrin FE, Lacroix S, Aviles-Trigueros M, David S Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain, 2005-02-02;128(0):854-66. 2005-02-02 [PMID: 15689362] (In Vivo, Mouse)
• Ching S, He L, Lai W, Quan N IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system. Brain Behav. Immun., 2005-03-01;19(2):127-37. 2005-03-01 [PMID: 15664785] (In Vivo, Mouse)

Bioinformatics

• Gene Symbol: Il1b
• Uniprot:
  • NP_032387()