Recombinant Mouse IGF-I/IGF-1 Protein, CF

Recombinant Mouse IGF-I/IGF-1 (Catalog # 791-MG) stimulates cell proliferation in a serum-free assay using the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.4-2 ng/mL.

1 µg/lane of Recombinant Mouse IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 8 kDa.

• Reactivity: Mu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Mouse IGF-I/IGF-1 Protein, CF Summary

• Details of Functionality: Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED₅₀ for this effect is 0.4-2 ng/mL.
• Source: E. coli-derived mouse IGF-I/IGF-1 protein
  Gly33-Ala102
• Accession #: Q8CAR0
• N-terminal Sequence: Gly33
• Protein/Peptide Type: Recombinant Proteins
• Gene: Igf1
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 7.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IGF-I/IGF-1 Protein, CF

• IBP1
• IGF1
• IGF-1
• IGF1A
• IGFI
• IGF-I
• IGF-IA
• IGF-IB
• insulin-like growth factor 1 (somatomedin C)
• insulin-like growth factor 1
• insulin-like growth factor I
• insulin-like growth factor IA
• insulin-like growth factor IB
• Mechano growth factor
• MGF
• Somatomedin A
• Somatomedin C
• somatomedin-C

Background

Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I/IGF-1 is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I/IGF-1 is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I/IGF-1 shares 94% and 99% aa sequence identity with human and rat IGF-I/IGF-1, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II/IGF-2. Circulating IGF-I/IGF-1 is produced by hepatocytes, while local IGF-I/IGF-1 is produced by many other tissues in which it has paracrine effects (1). IGF-I/IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I/IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I/IGF-1 association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10).

1. Philippou, A. et al. (2007) In Vivo 21:45.
2. Bell, G.I. et al. (1986) Nucleic Acids Res. 14:7873.
3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.

Publications for IGF-I/IGF-1 (791-MG)(68)

Publications using 791-MG

• X Hong, Y Jian, S Ding, J Zhou, X Zheng, H Zhang, B Zhou, C Zhuang, J Wan, X Tong Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke EBioMedicine, 2022;87(0):104406. 2022 [PMID: 36527899] (Bioassay, Mouse)
• A Hiroto, WK Kim, A Pineda, Y He, DH Lee, V Le, AW Olson, J Aldahl, CH Nenninger, AJ Buckley, GQ Xiao, J Geradts, Z Sun Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis Nature Communications, 2022;13(1):6552. 2022 [PMID: 36323713] (Bioassay, Mouse)
• L Wang, Z Chen, Y Feng, R Wang, X Bai, W Liu, D Wang RNA-seq transcriptomic analysis of 4-octyl itaconate repressing myogenic differentiation Archives of biochemistry and biophysics, 2022;0(0):109420. 2022 [PMID: 36183843] (Bioassay, Mouse)
• MRF Gosselin, V Mournetas, M Borczyk, S Verma, A Occhipinti, J Róg, L Bozycki, M Korostynsk, SC Robson, C Angione, C Pinset, DC Gorecki Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts Elife, 2022;11(0):. 2022 [PMID: 36164827] (Bioassay, Mouse)
• ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders Nature Neuroscience, 2022;25(9):1163-1178. 2022 [PMID: 36042312] (Bioassay, Mouse)
• SJ Cha, X Yu, BD Gregory, YS Lee, T Ishino, RO Opoka, CC John, M Jacobs-Lor Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways MBio, 2022;0(0):e0370821. 2022 [PMID: 35073748] (In Vivo, Mouse)
• R Deshycka, V Sudaryo, NJ Huang, Y Xie, LY Smeding, MK Choi, HL Ploegh, HF Lodish, N Pishesha Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity PLoS ONE, 2021;16(11):e0259353. 2021 [PMID: 34731223] (Bioassay, Mouse)
• P Maity, K Singh, L Krug, A Koroma, A Hainzl, W Bloch, S Kochanek, M Wlaschek, M Schorpp-Ki, P Angel, A Ignatius, H Geiger, K Scharffett Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging Cell Reports, 2021;36(9):109634. 2021 [PMID: 34469740] (In Vivo, Transgenic Mouse)
• HJ Kok, CN Crowder, L Koo Min Ch, HY Choi, N Lin, ER Barton Muscle insulin-like growth factor-I modulates murine craniofacial bone growth European cells & materials, 2021;41(0):72-89. 2021 [PMID: 34279041] (Western Blot Control, Mouse)
• M Mohrin, J Liu, J Zavala-Sol, S Bhargava, J Maxwell Tr, A Brito, D Hu, D Brooks, G Koukos, L Alabdulaal, JS Paw, K Hake, G Kolumam, ML Bouxsein, R Baron, Y Kutskova, A Freund Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells Aging Cell, 2021;0(0):e13313. 2021 [PMID: 33561324] (Bioassay, Mouse)
• M Kubota, M Scheibinge, TA Jan, S Heller Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea Cell Reports, 2021;34(3):108646. 2021 [PMID: 33472062] (Bioassay, Mouse)
• JB Conart, G Blot, S Augustin, G Millet-Pue, C Roubeix, F Beguier, H Charles-Me, S Touhami, JA Sahel, JP Berrod, T Léveillard, X Guillonnea, C Delarasse, F Sennlaub Insulin inhibits inflammation-induced cone death in retinal detachment J Neuroinflammation, 2020;17(1):358. 2020 [PMID: 33243251] (In Vivo, Mouse)
• J Xu, X Wang, J Chen, S Chen, Z Li, H Liu, Y Bai, F Zhi Embryonic stem cell-derived mesenchymal stem cells promote colon epithelial integrity and regeneration by elevating circulating IGF-1 in colitis mice Theranostics, 2020;10(26):12204-12222. 2020 [PMID: 33204338] (In Vivo, Mouse)
• T Hioki, T Kawabata, G Sakai, K Fujita, G Kuroyanagi, R Matsushima, W Kim, T Otsuka, H Iida, H Tokuda, O Kozawa Resveratrol suppresses insulin-like growth factor I-induced osteoblast migration: attenuation of the p44/p42 MAP kinase pathway Biosci. Biotechnol. Biochem., 2020;0(0):1-12. 2020 [PMID: 32862787] (Bioassay, Mouse)
• AL Gill, MZ Wang, B Levine, A Premasiri, FG Vieira Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells Int J Mol Sci, 2019;20(24):. 2019 [PMID: 31835664] (Bioassay, Mouse)
• S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei, NM Santerre, P Loughran, TR Billiar TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway JCI Insight, 2019;4(22):. 2019 [PMID: 31723054] (Bioassay, Mouse)
• T Abe, R Kazama, H Okauchi, K Oishi Food deprivation during active phase induces skeletal muscle atrophy via IGF-1 reduction in mice Arch. Biochem. Biophys., 2019;0(0):108160. 2019 [PMID: 31639326] (In Vivo, Mouse)
• MW Laschke, E Kontaxi, C Scheuer, A He beta , P Karschnia, MD Menger Insulin-like growth factor 1 stimulates the angiogenic activity of adipose tissue-derived microvascular fragments J Tissue Eng, 2019;10(0):2041731419879. 2019 [PMID: 31632630] (Bioassay, Mouse)
• SK Nandakumar, SK McFarland, LM Mateyka, CA Lareau, JC Ulirsch, LS Ludwig, G Agarwal, JM Engreitz, B Przychodze, M McConkey, GS Cowley, JG Doench, JP Maciejewsk, BL Ebert, DE Root, VG Sankaran Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis Elife, 2019;8(0):. 2019 [PMID: 31070582] (Bioassay, Mouse)
• I Meln, G Wolff, T Gajek, J Koddebusch, S Lerch, L Harbrecht, W Hong, I Bayindir-B, D Krunic, HG Augustin, A Vegiopoulo Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth Mol Metab, 2019;24(0):139-148. 2019 [PMID: 31003943] (Bioassay, Mouse)
• T Oyanagi, N Takeshita, M Hara, E Ikeda, T Chida, D Seki, M Yoshida, M Seiryu, I Takano, S Kimura, M Oshima, T Tsuji, T Takano-Yam Insulin-like growth factor 1 modulates bioengineered tooth morphogenesis Sci Rep, 2019;9(1):368. 2019 [PMID: 30675004] (Bioassay, Mouse)
• L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice Aging (Albany NY), 2018;0(0):. 2018 [PMID: 30513510] (Mouse)
• SY Lee, ED Abel, F Long Glucose metabolism induced by Bmp signaling is essential for murine skeletal development Nat Commun, 2018;9(1):4831. 2018 [PMID: 30446646] (Bioassay, Mouse)
• LE Hillers, JV D'Amato, T Chamberlin, G Paderta, LM Arendt Obesity-Activated Adipose-Derived Stromal Cells Promote Breast Cancer Growth and Invasion Neoplasia, 2018;20(11):1161-1174. 2018 [PMID: 30317122] (Bioassay, Mouse)
• AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells Nat Commun, 2018;9(1):3708. 2018 [PMID: 30213958] (Cell Culture, Mouse)
• A Rasheed, R Tsai, CL Cummins Loss of the Liver X Receptors Disrupts the Balance of Hematopoietic Populations, With Detrimental Effects on Endothelial Progenitor Cells J Am Heart Assoc, 2018;7(10):. 2018 [PMID: 29739800] (Bioassay, Mouse)
• L Decourtye, M Clemessy, E Mire, T Ledent, L Périn, IC Robinson, Y Le Bouc, L Kappeler Impact of insulin on primary arcuate neurons culture is dependent on early-postnatal nutritional status and neuronal subpopulation PLoS ONE, 2018;13(2):e0193196. 2018 [PMID: 29466413] (Bioassay, Mouse)
• MC Fernandez, R Rayes, B Ham, N Wang, F Bourdeau, S Milette, M Lllemann, N Bird, A Majeed, J Xu, T Kisselova, P Brodt The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells Oncotarget, 2017;8(32):52281-52293. 2017 [PMID: 28881729] (Bioassay, Mouse)
• NJ Huang, N Pishesha, J Mukherjee, S Zhang, R Deshycka, V Sudaryo, M Dong, CB Shoemaker, HF Lodish Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin Nat Commun, 2017;8(1):423. 2017 [PMID: 28871080] (Bioassay, Mouse)
• R Cintron-Co, M Sanchez-Al, W Nguyen, S Mori, R Gonzalez-R, T Lien, T Bartfai, S Aïd, JC François, M Holzenberg, B Conti Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 [PMID: 28827363] (In Vivo, Mouse)
• T Iki, M Tanaka, SI Kitajiri, T Kita, Y Kawasaki, A Mizukoshi, W Fujibuchi, T Nakagawa, T Nakahata, J Ito, K Omori, MK Saito Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres PLoS ONE, 2017;12(6):e0179901. 2017 [PMID: 28662075] (Bioassay, Mouse)
• M Akiel, C Guo, X Li, D Rajasekara, RG Mendoza, CL Robertson, N Jariwala, F Yuan, MA Subler, J Windle, DK Garcia, Z Lai, HH Chen, Y Chen, S Giashuddin, PB Fisher, XY Wang, D Sarkar IGFBP7 Deletion Promotes Hepatocellular Carcinoma Cancer Res., 2017;0(0):. 2017 [PMID: 28619711] (Bioassay, Mouse)
• R Garg, JM Blando, CJ Perez, MC Abba, F Benavides, MG Kazanietz Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis through the CXCL13-CXCR5 Pathway Cell Rep, 2017;19(2):375-388. 2017 [PMID: 28402859] (Bioassay, Mouse)
• L Chen, W Zeng, B Yang, X Cui, C Feng, L Wang, H Wang, X Zhou, P Li, F Lv, T Li Expression of antisense of microRNA-26a-5p in mesenchymal stem cells increases their therapeutic effects against cirrhosis Am J Transl Res, 2017;9(3):1500-1508. 2017 [PMID: 28386375] (Bioassay, Mouse)
• S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons Proc. Natl. Acad. Sci. U.S.A, 2017;114(12):E2486-E2493. 2017 [PMID: 28270618] (Bioassay, Mouse)
• G Valenti, HM Quinn, GJ Heynen, L Lan, JD Holland, R Vogel, A Wulf-Golde, W Birchmeier Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors Cancer Res, 2017;0(0):. 2017 [PMID: 28202523] (Bioassay, Mouse)
• Aiko Inoue Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice J Cachexia Sarcopenia Muscle, 2016;0(0):. 2016 [PMID: 27897419] (Mouse)
• EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy Nat Commun, 2016;7(0):13685. 2016 [PMID: 27897169] (Bioassay, Mouse)
• Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro PLoS ONE, 2016;11(10):e0164579. 2016 [PMID: 27755610] (Bioassay, Mouse)
• L R Batista-Si Mycobacterium leprae-induced Insulin-like Growth Factor I attenuates antimicrobial mechanisms, promoting bacterial survival in macrophages Sci Rep, 2016;6(0):27632. 2016 [PMID: 27282338] (Bioassay, Mouse)
• Thor Tejada IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27274047] (Bioassay, Mouse)
• The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination with Cell Polarization During Ameloblast Differentiation J Bone Miner Res, 2016;0(0):. 2016 [PMID: 27218883] (Bioassay, Mouse)
• T Tando, A Hirayama, M Furukawa, Y Sato, T Kobayashi, A Funayama, A Kanaji, W Hao, R Watanabe, M Morita, T Oike, K Miyamoto, T Soga, M Nomura, A Yoshimura, M Tomita, M Matsumoto, M Nakamura, Y Toyama, T Miyamoto Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy J. Biol. Chem., 2016;291(23):12184-94. 2016 [PMID: 27129272] (Bioassay, Mouse)
• Barkho B, Monuki E Proliferation of cultured mouse choroid plexus epithelial cells. PLoS ONE, 2015;10(3):e0121738. 2015 [PMID: 25815836] (Bioassay, Mouse)
• Shaw A, Pickup M, Chytil A, Aakre M, Owens P, Moses H, Novitskiy S TGFbeta signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLoS ONE, 2015;10(1):e0117908. 2015 [PMID: 25629162] (Bioassay, Mouse)
• Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment. Sci Rep, 2014;4(0):6222. 2014 [PMID: 25164363] (Bioassay, Mouse)
• Wang X, Li Q, Hu Q, Suntharalingam P, From A, Zhang J Intra-myocardial injection of both growth factors and heart derived Sca-1+/CD31- cells attenuates post-MI LV remodeling more than does cell transplantation alone: neither intervention enhances functionally significant cardiomyocyte regeneration. PLoS ONE, 2014;9(2):e95247. 2014 [PMID: 24919180] (Bioassay, Mouse)
• Lou , Xiangxin, Dong , Youyi, Xie , Jing, Wang , Xianliu, Yang , Lianglia, Tokuda , Masaaki, Zhang , Yanzhong Comparing the cultivated cochlear cells derived from neonatal and adult mouse. J Transl Med, 2014;12(0):150. 2014 [PMID: 24884939] (Bioassay, Mouse)
• Harvey A, Lashinger L, Hays D, Harrison L, Lewis K, Fischer S, Hursting S Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner. PLoS ONE, 2014;9(5):e94151. 2014 [PMID: 24804677] (Bioassay, Mouse)
• Jiang X, McClellan S, Barrett R, Foldenauer M, Hazlett L HGF signaling impacts severity of Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci, 2014;55(4):2180-90. 2014 [PMID: 24618323] (In Vivo, Mouse)
• Wang Z, Dela Cruz R, Ji F, Guo S, Zhang J, Wang Y, Feng G, Birnbaumer L, Jiang M, Chu W G(i)alpha proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells. Cell Commun Signal, 2014;12(0):10. 2014 [PMID: 24521094] (Bioassay, Mouse)
• Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T Myostatin stimulates, not inihibits, C2C12 myoblast proliferation. Endocrinology, 2014;155(3):670-5. 2014 [PMID: 24424069] (Bioassay, Mouse)
• Wei W, Howard P, Macarak E Recombinant insulin-like growth factor-1 activates satellite cells in the mouse urethral rhabdosphincter. BMC Urol, 2013;13(0):62. 2013 [PMID: 24279352] (In Vivo, Mouse)
• Wrann C, White J, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin J, Greenberg M, Spiegelman B Exercise induces hippocampal BDNF through a PGC-1alpha/FNDC5 pathway. Cell Metab, 2013;18(5):649-59. 2013 [PMID: 24120943] (Cell Culture, Mouse)
• Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells. Exp Cell Res, 2014;320(1):54-61. 2014 [PMID: 24080013] (Bioassay, Mouse)
• Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells. Stem Cells, 2013;31(4):627-40. 2013 [PMID: 23335250] (Bioassay, Mouse)
• Guo T, Landsman L, Li N, Hebrok M Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs. Diabetes, 2014;62(5):1581-92. 2014 [PMID: 23305648] (Bioassay, Mouse)
• Takehara , Yuji, Yabuuchi , Akiko, Ezoe , Kenji, Kuroda , Tomoko, Yamadera , Rie, Sano , Chiaki, Murata , Nana, Aida , Takuya, Nakama , Ken, Aono , Fumihito, Aoyama , Naoki, Kato , Keiich, Kato , Osamu The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function. Lab Invest, 2013;93(2):181-93. 2013 [PMID: 23212100] (Bioassay, Mouse)
• Zhao H, Zhao X, Cao X, Wu G Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice. Immun Ageing, 2012;9(1):12. 2012 [PMID: 22640633] (Bioassay, Mouse)
• Mehta HH, Gao Q, Galet C IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res., 2011;71(15):5154-63. 2011 [PMID: 21697285] (ELISA (Standard), N/A)
• Sanchez-Alavez M, Osborn O, Tabarean IV Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors. J. Biol. Chem., 2011;286(17):14983-90. 2011 [PMID: 21330367] (In Vivo, Mouse)
• Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM A critical role for IGF-II in memory consolidation and enhancement. Nature, 2011;469(7331):491-7. 2011 [PMID: 21270887] (In Vivo, Rat)
• Yamada PM, Mehta HH, Hwang D Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation. Endocrinology, 2010;151(12):5741-50. 2010 [PMID: 20926583] (ELISA (Standard), N/A)
• Hu J, Dong A, Fernandez-Ruiz V, Shan J, Kawa M, Martinez-Anso E, Prieto J, Qian C Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res., 2009;69(17):6951-9. 2009 [PMID: 19690140] (Bioassay, Mouse)
• Ostrovsky O, Ahmed NT, Argon Y The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation. Mol. Biol. Cell, 2009;20(6):1855-64. 2009 [PMID: 19158397] (Bioassay, Mouse)
• Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am. J. Respir. Crit. Care Med., 2008;178(2):149-57. 2008 [PMID: 18436791] (In Vivo, Mouse)
• Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glode LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res., 2007;67(22):11083-91. 2007 [PMID: 18006855] (ELISA (Standard), N/A)
• Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci., 2006;31(1):149-60. 2006 [PMID: 16297637] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Igf1
• Uniprot:
  • Q8CAR0()