Recombinant Mouse IGF-I/IGF-1 Protein, CF


Recombinant Mouse IGF-I/IGF-1 (Catalog # 791-MG) stimulates cell proliferation in a serum-free assay using the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.4-2 ng/mL.
1 µg/lane of Recombinant Mouse IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 8 kDa.

Product Details

Reactivity MuSpecies Glossary
Applications Bioactivity

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Recombinant Mouse IGF-I/IGF-1 Protein, CF Summary

Details of Functionality
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.4-2 ng/mL.
E. coli-derived mouse IGF-I/IGF-1 protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


  • Bioactivity
Theoretical MW
7.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using
791-MG in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse IGF-I/IGF-1 Protein, CF

  • IBP1
  • IGF1
  • IGF-1
  • IGF1A
  • IGFI
  • IGF-I
  • IGF-IA
  • IGF-IB
  • insulin-like growth factor 1 (somatomedin C)
  • insulin-like growth factor 1
  • insulin-like growth factor I
  • insulin-like growth factor IA
  • insulin-like growth factor IB
  • Mechano growth factor
  • MGF
  • Somatomedin A
  • Somatomedin C
  • somatomedin-C


Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I/IGF-1 is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I/IGF-1 is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I/IGF-1 shares 94% and 99% aa sequence identity with human and rat IGF-I/IGF-1, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II/IGF-2. Circulating IGF-I/IGF-1 is produced by hepatocytes, while local IGF-I/IGF-1 is produced by many other tissues in which it has paracrine effects (1). IGF-I/IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I/IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I/IGF-1 association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10).

  1. Philippou, A. et al. (2007) In Vivo 21:45.
  2. Bell, G.I. et al. (1986) Nucleic Acids Res. 14:7873.
  3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
  4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
  5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
  6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
  7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
  8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
  9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
  10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.

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Publications for IGF-I/IGF-1 (791-MG)(68)

We have publications tested in 4 confirmed species: Mouse, Rat, N/A, Transgenic Mouse.

We have publications tested in 5 applications: Bioassay, Cell Culture, ELISA (Standard), In Vivo, Western Blot Control.

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Showing Publications 1 - 10 of 68. Show All 68 Publications.
Publications using 791-MG Applications Species
X Hong, Y Jian, S Ding, J Zhou, X Zheng, H Zhang, B Zhou, C Zhuang, J Wan, X Tong Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke EBioMedicine, 2022;87(0):104406. 2022 [PMID: 36527899] (Bioassay, Mouse) Bioassay Mouse
A Hiroto, WK Kim, A Pineda, Y He, DH Lee, V Le, AW Olson, J Aldahl, CH Nenninger, AJ Buckley, GQ Xiao, J Geradts, Z Sun Stromal androgen signaling acts as tumor niches to drive prostatic basal epithelial progenitor-initiated oncogenesis Nature Communications, 2022;13(1):6552. 2022 [PMID: 36323713] (Bioassay, Mouse) Bioassay Mouse
L Wang, Z Chen, Y Feng, R Wang, X Bai, W Liu, D Wang RNA-seq transcriptomic analysis of 4-octyl itaconate repressing myogenic differentiation Archives of biochemistry and biophysics, 2022;0(0):109420. 2022 [PMID: 36183843] (Bioassay, Mouse) Bioassay Mouse
MRF Gosselin, V Mournetas, M Borczyk, S Verma, A Occhipinti, J Róg, L Bozycki, M Korostynsk, SC Robson, C Angione, C Pinset, DC Gorecki Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts Elife, 2022;11(0):. 2022 [PMID: 36164827] (Bioassay, Mouse) Bioassay Mouse
ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders Nature Neuroscience, 2022;25(9):1163-1178. 2022 [PMID: 36042312] (Bioassay, Mouse) Bioassay Mouse
SJ Cha, X Yu, BD Gregory, YS Lee, T Ishino, RO Opoka, CC John, M Jacobs-Lor Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways MBio, 2022;0(0):e0370821. 2022 [PMID: 35073748] (In Vivo, Mouse) In Vivo Mouse
R Deshycka, V Sudaryo, NJ Huang, Y Xie, LY Smeding, MK Choi, HL Ploegh, HF Lodish, N Pishesha Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity PLoS ONE, 2021;16(11):e0259353. 2021 [PMID: 34731223] (Bioassay, Mouse) Bioassay Mouse
P Maity, K Singh, L Krug, A Koroma, A Hainzl, W Bloch, S Kochanek, M Wlaschek, M Schorpp-Ki, P Angel, A Ignatius, H Geiger, K Scharffett Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging Cell Reports, 2021;36(9):109634. 2021 [PMID: 34469740] (In Vivo, Transgenic Mouse) In Vivo Transgenic Mouse
HJ Kok, CN Crowder, L Koo Min Ch, HY Choi, N Lin, ER Barton Muscle insulin-like growth factor-I modulates murine craniofacial bone growth European cells & materials, 2021;41(0):72-89. 2021 [PMID: 34279041] (Western Blot Control, Mouse) Western Blot Control Mouse
M Mohrin, J Liu, J Zavala-Sol, S Bhargava, J Maxwell Tr, A Brito, D Hu, D Brooks, G Koukos, L Alabdulaal, JS Paw, K Hake, G Kolumam, ML Bouxsein, R Baron, Y Kutskova, A Freund Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells Aging Cell, 2021;0(0):e13313. 2021 [PMID: 33561324] (Bioassay, Mouse) Bioassay Mouse
Show All 68 Publications.

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Gene Symbol Igf1