Recombinant Mouse CXCL1/KC Protein

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse CXCL1/KC Protein Summary

• Details of Functionality: Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR2. The ED₅₀ for this effect is 3-15 ng/mL.
• Source: E. coli-derived mouse CXCL1/GRO alpha/KC/CINC-1 protein
  Arg20-Lys96
• Accession #: P12850
• N-terminal Sequence: Arg20
• Protein/Peptide Type: Recombinant Proteins
• Gene: Cxcl1
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity2
• Theoretical MW: 8 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse CXCL1/KC Protein

• CINC1
• CINC-1
• CXCL1
• FSP
• GRO alpha
• GRO1
• GROa
• KC
• MGSA
• MGSA-a
• MGSA-alpha
• NAP-3
• SCYB1

Background

CXCL1, also known as KC, GRO alpha , and CINC-1, is an approximately 8 kDa proinflammatory chemokine that plays a key role in neutrophil migration and activation (1). Mature mouse CXCL1 shares 64% and 92% aa sequence identity with human and rat CXCL1, respectively [oquendo 4133, ryseck 266, cochran 939]. It is produced by many cell types in inflammatory sites and during chronic inflammatory diseases (1). CXCL1 can associate into bioactive dimers and primarily signals through CXCR2/IL-8 RB but can also bind with lower affinity to CXCR2/IL-8 RA (5-7). It induces neutrophil migration, extravasation, respiratory burst, and degranulation and also induces T cells to produce proinflammatory IL-17 (6, 8, 9). CXCL1 additionally binds to Syndecan-1 on epithelial cells which acts as a sink for CXCL1 activity until Syndecan-1 cleavage by MMP-7 (10). CXCL1 is up-regulated in spinal cord astrocytes by inflammatory stimuli or tumor cell injection, and it exacerbates pain sensation by potentiating excitatory NMDA neurotransmission (11, 12). In the circulatory system, CXCL1 interacts with CXCR2 on endothelial cells to promote lymphatic tube formation and angiogenesis (13, 14). It promotes the hypertrophic differentiation of chondrocytes resulting in cartilage matrix deposition, calcification, and remodeling (15). It interacts with both CXCR1 and CXCR2 on adipose stromal cells and promotes their recruitment to prostate tumors in obese patients (16). It also binds CXCR2 on ovarian cancer cells, leading to cleavage of cell surface HB-EGF, transactivation of EGF R, and cell proliferation (17).

1. Strieter, R.M. et al. (2005) Cytokine Growth Factor Rev. 16:593.
2. Cochran, B.H. et al. (1983) Cell 33:939.
3. Oquendo, P. et al. (1989) J. Biol. Chem. 264:4133.
4. Ryseck, R.P. et al. (1989) Exp. Cell Res. 180:266.
5. Sawant, K.V. et al. (2015) J. Innate Immun. 7:647.
6. Geiser, T. et al. (1993) J. Biol. Chem. 268:15419.
7. Ahuja, S.K. and P.M. Murphy (1996) J. Biol. Chem. 271:20545.
8. Jin, L. et al. (2014) J. Immunol. 193:3549.
9. De Filippo, K. et al. (2013) Blood 121:4930.
10. Gill, S.E. et al. (2016) Am. J. Respir. Cell. Mol. Biol. PMID 26934670.
11. Cao, D.-L. et al. (2014) Exp. Neurol. 261:328.
12. Xu, J. et al. (2014) J. Neuroinflamm. 11:38.
13. Xu, J. et al. (2012) Int. J. Cancer 130:787.
14. Miyake, M. et al. (2013) Lab. Invest. 93:768.
15. Merz, D. et al. (2003) J. Immunol. 171:4406.
16. Zhang, T. et al. (2016) Nat. Commun. 7:11674.
17. Bolitho, C. et al. (2010) Endocr. Relat. Cancer 17:929.

Publications for CXCL1/GRO alpha/KC/CINC-1 (453-KC)(61)

Publications using 453-KC

• Chen, K;Ye, Q;Zhang, Y;Qi, Z;Huang, Y;Lu, W;Wang, X;Wang, Y;Cao, L;Qiu, S;Xu, Y;Huang, J;Xie, J; CXCL1-CXCR2 signaling mediates the activation of microglia in the nucleus tractus solitarii to promote pancreatic cancer-induced pain Brain, behavior, and immunity 2024-11-10 [PMID: 39528100] (Bioassay, Mouse)
• Goretzko, J;Pauels, I;Heitzig, N;Thomas, K;Kardell, M;Na beta , J;Krogsaeter, EK;Schloer, S;Spix, B;Linard Matos, AL;Leser, C;Wegner, T;Glorius, F;Bracher, F;Gerke, V;Rossaint, J;Grimm, C;Rescher, U; P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2 Cell reports 2023-11-29 [PMID: 38039128] (Bioassay, Mouse)
• L Wen, A Marki, Z Wang, M Orecchioni, J Makings, M Billitti, E Wang, SSA Suthahar, K Kim, WB Kiosses, Z Mikulski, K Ley A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in�vivo Cell Reports, 2022-05-31;39(9):110876. 2022-05-31 [PMID: 35649374] (Bioassay, Mouse)
• WC Poller, J Downey, AA Mooslechne, N Khan, L Li, CT Chan, CS McAlpine, C Xu, F Kahles, S He, H Janssen, JE Mindur, S Singh, MG Kiss, L Alonso-Her, Y Iwamoto, RH Kohler, LP Wong, K Chetal, SJ Russo, RI Sadreyev, R Weissleder, M Nahrendorf, PS Frenette, M Divangahi, FK Swirski Brain motor and fear circuits regulate leukocytes during acute stress Nature, 2022-05-30;0(0):. 2022-05-30 [PMID: 35636458] (In Vivo, Mouse)
• T Bromberger, S Klapproth, M Sperandio, M Moser Humanized beta2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation Cells, 2022-05-03;11(9):. 2022-05-03 [PMID: 35563841] (Bioassay, Mouse)
• R Roy, J Zayas, SK Singh, K Delgado, SJ Wood, MF Mohamed, DM Frausto, YA Albalawi, TP Price, R Estupinian, EF Giurini, TM Kuzel, A Zloza, J Reiser, SH Shafikhani Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound Elife, 2022-02-03;11(0):. 2022-02-03 [PMID: 35112667] (Bioassay, Mouse)
• HI Warheit-Ni, SJ Edwards, S SenGupta, CA Parent, X Zhou, DN O'Dwyer, BB Moore Fibrotic lung disease inhibits innate immune responses to Staphylococcal pneumonia via impaired neutrophil and macrophage function JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 34990413] (In Vivo, Mouse)
• G Crainiciuc, M Palomino-S, M Molina-Mor, J Sicilia, DG Aragones, JLY Li, R Madurga, JM Adrover, A Aroca-Crev, S Martin-Sal, AS Del Valle, SD Castillo, HCE Welch, O Soehnlein, M Graupera, F Sánchez-Ca, A Zarbock, TE Smithgall, M Di Pilato, TR Mempel, PL Tharaux, SF González, A Ayuso-Saci, LG Ng, GF Calvo, I González-D, F Díaz-de-Ma, A Hidalgo Behavioural immune landscapes of inflammation Nature, 2022-01-05;0(0):. 2022-01-05 [PMID: 34987220] (In Vivo, Mouse)
• P Agarwal, H Li, K Choi, K Hueneman, J He, RS Welner, DT Starczynow, R Bhatia TNF-alpha-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling Cell Reports, 2021-07-13;36(2):109386. 2021-07-13 [PMID: 34260914] (Bioassay, Mouse)
• S Cai, S Paudel, L Jin, L Ghimire, CM Taylor, N Wakamatsu, D Bhattarai, S Jeyaseelan NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis Mucosal Immunol, 2020-11-23;0(0):. 2020-11-23 [PMID: 33230225] (In Vivo, Mouse)
• Y Vagima, D Gur, N Erez, H Achdout, M Aftalion, Y Levy, A Zauberman, A Tidhar, H Gutman, S Lazar, T Israely, N Paran, S Melamed, T Brosh-Niss, T Chitlaru, I Sagi, E Mamroud Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments Sci Rep, 2020-11-05;10(1):19116. 2020-11-05 [PMID: 33154422] (Cell Culture, Mouse)
• WC Lin, KM Gowdy, JH Madenspach, RL Zemans, K Yamamoto, MR Lyons-Cohe, H Nakano, K Janardhan, CJ Williams, DN Cook, JP Mizgerd, MB Fessler Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace J. Clin. Invest., 2020-01-02;0(0):. 2020-01-02 [PMID: 31550239] (In Vivo, Mouse)
• S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity Front Microbiol, 2019-06-25;10(0):1421. 2019-06-25 [PMID: 31293551] (Bioassay, Mouse)
• FH Brennan, T Jogia, ER Gillespie, LV Blomster, XX Li, B Nowlan, GM Williams, E Jacobson, GW Osborne, FA Meunier, SM Taylor, KE Campbell, KP MacDonald, JP Levesque, TM Woodruff, MJ Ruitenberg Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2 JCI Insight, 2019-05-02;4(9):. 2019-05-02 [PMID: 31045582] (Bioassay, Mouse)
• AC Luissint, HC Williams, W Kim, S Flemming, V Azcutia, RS Hilgarth, MNO Leary, TL Denning, A Nusrat, CA Parkos Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice Mucosal Immunol, 2019-02-11;0(0):. 2019-02-11 [PMID: 30745566] (Bioassay, Mouse)
• TA Pádua, ND Torres, ALP Candéa, MFS Costa, JD Silva, JL Silva-Filh, FTM Costa, PRM Rocco, MC Souza, MG Henriques Therapeutic effect of Lipoxin A4 �in malaria-induced acute lung injury J. Leukoc. Biol., 2018-01-03;0(0):. 2018-01-03 [PMID: 29345368] (Bioassay, Mouse)
• J García-Pri, R Villena-Gu, M Gómez, E Bernardo, A Pun-García, I García-Lun, G Crainiciuc, R Fernández-, V Sreeramkum, R Bourio-Mar, JM García-Rui, AS Del Valle, D Sanz-Rosa, G Pizarro, A Fernández-, A Hidalgo, V Fuster, B Ibanez Neutrophil stunning by metoprolol reduces infarct size Nat Commun, 2017-04-18;8(0):14780. 2017-04-18 [PMID: 28416795] (Bioassay, Mouse)
• T Ishiguro, T Fukawa, K Akaki, K Nagaoka, T Takeda, Y Iwakura, K Inaba, K Takahara Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice Eur. J. Immunol, 2017-02-22;0(0):. 2017-02-22 [PMID: 28127756] (Bioassay, Mouse)
• J Latasiewic, A Artz, D Jing, MP Blanco, SM Currie, MV Avila, M Schnoor, D Vestweber HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1 J. Leukoc. Biol, 2017-01-25;0(0):. 2017-01-25 [PMID: 28122813] (In Vivo, Mouse)
• Clara Jana-Lui Busch Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice Hepatology, 2017-02-03;0(0):. 2017-02-03 [PMID: 27981604] (ELISA (Standard))
• iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation Cell Rep, 2016-09-20;16(12):3260-72. 2016-09-20 [PMID: 27653688] (In Vivo, Mouse)
• Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype PLoS ONE, 2016-08-15;11(8):e0159986. 2016-08-15 [PMID: 27525971] (Bioassay, Mouse)
• Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson L, McEver R Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow. J Immunol, 2015-09-09;195(8):3880-9. 2015-09-09 [PMID: 26355151] (Bioassay, Mouse)
• Spahn J, Li W, Bribriesco A, Liu J, Shen H, Ibricevic A, Pan J, Zinselmeyer B, Brody S, Goldstein D, Krupnick A, Gelman A, Miller M, Kreisel D DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation. J Immunol, 2015-03-11;194(8):4039-48. 2015-03-11 [PMID: 25762783] (Bioassay, Mouse)
• Fujihara Y, Takato T, Hoshi K Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration. Stem Cells, 2014-05-01;32(5):1208-19. 2014-05-01 [PMID: 24446149] (Bioassay, Human, Mouse)
• Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol, 2013-04-15;190(10):5329-36. 2013-04-15 [PMID: 23589623] (Bioassay, Mouse)
• Aeffner F, Davis I Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice. PLoS ONE, 2012-10-02;7(10):e46660. 2012-10-02 [PMID: 23056391] (In Vivo, Mouse)
• Reichel CA, Puhr-Westerheide D, Zuchtriegel G, Uhl B, Berberich N, Zahler S, Wymann MP, Luckow B, Krombach F C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms. Blood, 2012-06-06;120(4):880-90. 2012-06-06 [PMID: 22674804] (In Vivo, Mouse)
• Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am. J. Pathol., 2011-10-01;179(6):2730-9. 2011-10-01 [PMID: 21967814] (ELISA (Standard))
• Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa. J. Immunol., 2011-03-25;186(9):5425-34. 2011-03-25 [PMID: 21441447] (In Vivo, Mouse)
• Jang JE, Hod EA, Spitalnik SL CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. J. Clin. Invest., 2011-03-07;121(4):1397-401. 2011-03-07 [PMID: 21383500] (In Vivo, Mouse)
• Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J. Leukoc. Biol., 2010-11-02;89(2):269-82. 2010-11-02 [PMID: 21048214] (Bioassay, Mouse)
• Petri B, Broermann A, Li H, Khandoga AG, Zarbock A, Krombach F, Goerge T, Schneider SW, Jones C, Nieswandt B, Wild MK, Vestweber D von Willebrand factor promotes leukocyte extravasation. Blood, 2010-08-17;116(22):4712-9. 2010-08-17 [PMID: 20716766] (In Vivo, Mouse)
• Massena S, Christoffersson G, Hjertstrom E, Zcharia E, Vlodavsky I, Ausmees N, Rolny C, Li JP, Phillipson M A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood, 2010-06-08;116(11):1924-31. 2010-06-08 [PMID: 20530797] (Bioassay, Mouse)
• Jimenez F, Quinones MP, Martinez HG, Estrada CA, Clark K, Garavito E, Ibarra J, Melby PC, Ahuja SS CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B. J. Immunol., 2010-04-19;184(10):5571-81. 2010-04-19 [PMID: 20404272] (Bioassay, Mouse)
• Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B, Mantovani A Regulation of leukocyte recruitment by the long pentraxin PTX3. Nat. Immunol., 2010-03-07;11(4):328-34. 2010-03-07 [PMID: 20208538] (In Vivo, Mouse)
• Traylor ZP, Yu EN, Davis IC Respiratory syncytial virus induces airway insensitivity to beta-agonists in BALB/c mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-12-04;298(3):L437-45. 2009-12-04 [PMID: 19965982] (In Vivo, Mouse)
• Schneider DJ, Lindsay JC, Zhou Y, Molina JG, Blackburn MR Adenosine and osteopontin contribute to the development of chronic obstructive pulmonary disease. FASEB J., 2009-08-31;24(1):70-80. 2009-08-31 [PMID: 19720619] (In Vivo, Mouse)
• Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med., 2009-08-06;180(8):720-30. 2009-08-06 [PMID: 19661246] (In Vivo, Mouse)
• Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9. 2009-03-16 [PMID: 19289819] (ELISA (Standard))
• Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 2009-03-13;11(4):524-30. 2009-03-13 [PMID: 19286469] (ELISA (Standard))
• Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood, 2009-03-03;113(19):4799-809. 2009-03-03 [PMID: 19258599] (In Vivo, Mouse)
• Chen SM, Cheng DS, Williams BJ, Sherrill TP, Han W, Chont M, Saint-Jean L, Christman JW, Sadikot RT, Yull FE, Blackwell TS The nuclear factor kappa-B pathway in airway epithelium regulates neutrophil recruitment and host defence following Pseudomonas aeruginosa infection. Clin. Exp. Immunol., 2008-07-18;0(0):. 2008-07-18 [PMID: 18647324] (In Vivo, Mouse)
• Kerfoot SM, Andonegui G, Bonder CS, Liu L Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo. Am. J. Physiol. Heart Circ. Physiol., 2008-04-18;294(6):H2524-34. 2008-04-18 [PMID: 18424631] (In Vivo, Mouse)
• Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA (Standard))
• Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. J. Immunol., 2008-03-01;180(5):3305-12. 2008-03-01 [PMID: 18292555] (In Vivo, Mouse)
• Kagari T, Tanaka D, Doi H, Iwakura Y, Shimozato T Anti-type II collagen antibody accelerates arthritis via CXCR2-expressing cells in IL-1 receptor antagonist-deficient mice. Eur. J. Immunol., 2007-10-01;37(10):2753-63. 2007-10-01 [PMID: 17823985] (Bioassay, Mouse)
• Liu L, Puri KD, Penninger JM, Kubes P Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood, 2007-05-08;110(4):1191-8. 2007-05-08 [PMID: 17488877] (Bioassay, Mouse)
• Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S High pressure promotes monocyte adhesion to the vascular wall. Circ. Res., 2007-03-29;100(8):1226-33. 2007-03-29 [PMID: 17395876] (Bioassay, Human)
• Zemann B, Urtz N, Reuschel R, Mechtcheriakova D, Bornancin F, Badegruber R, Baumruker T, Billich A Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice. Immunol. Lett., 2007-01-30;109(1):56-63. 2007-01-30 [PMID: 17292973] (Bioassay, In Vivo, Mouse)
• Fan X, Patera AC, Pong-Kennedy A, Deno G, Gonsiorek W, Manfra DJ, Vassileva G, Zeng M, Jackson C, Sullivan L, Sharif-Rodriguez W, Opdenakker G, Van Damme J, Hedrick JA, Lundell D, Lira SA, Hipkin RW Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J. Biol. Chem., 2006-12-29;282(16):11658-66. 2006-12-29 [PMID: 17197447] (Binding Assay, Mouse)
• Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol., 2006-12-15;177(12):8650-7. 2006-12-15 [PMID: 17142765] (ELISA (Standard))
• Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm. Res., 2006-11-01;55(11):457-64. 2006-11-01 [PMID: 17122962] (ELISA (Standard))
• Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Bystrom M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect. Immun., 2006-09-18;74(12):6730-8. 2006-09-18 [PMID: 16982824] (ELISA (Standard))
• Ramos CD, Fernandes KS, Canetti C, Teixeira MM, Silva JS, Cunha FQ Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur. J. Immunol., 2006-08-01;36(8):2025-34. 2006-08-01 [PMID: 16856209] (ELISA (Standard))
• Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA (Standard))
• Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J. Immunol., 2006-07-01;177(1):612-20. 2006-07-01 [PMID: 16785559] (ELISA (Standard))
• Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, Mao L, Wistuba I, Strieter RM, Kurie JM High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res., 2006-04-15;66(8):4198-207. 2006-04-15 [PMID: 16618742] (Bioassay, Mouse)
• Mihara K, Smit MJ, Krajnc-Franken M, Gossen J, Rooseboom M, Dokter W Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur. J. Immunol., 2005-09-01;35(9):2573-82. 2005-09-01 [PMID: 16094689] (In Vivo, Mouse)
• Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA (Standard))
• Venturi GM, Tu L, Kadono T, Khan AI, Fujimoto Y, Oshel P, Bock CB, Miller AS, Albrecht RM, Kubes P, Steeber DA, Tedder TF Leukocyte migration is regulated by L-selectin endoproteolytic release. Immunity, 2003-11-01;19(5):713-24. 2003-11-01 [PMID: 14614858] (In Vivo, Mouse)

Review for CXCL1/GRO alpha/KC/CINC-1 (453-KC) (1)

Average Rating: 4

(Based on 1 review)

reviewed by: Verified Customer In vitro bioactivity in cell culture 11/20/2018

Summary

• Application: In vitro bioactivity in cell culture
• Lot: 0W0216031

Bioinformatics

• Gene Symbol: Cxcl1
• Uniprot:
  • P12850()