Recombinant Human Oncostatin M (OSM) Protein, CF

Recombinant human Oncostatin M / OSM (295-OM/CF) induces proliferation in the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.05-0.3 ng/mL.

• Reactivity: Hu
• Applications: Bioactivity
• Format: Carrier-Free

Recombinant Human Oncostatin M (OSM) Protein, CF Summary

• Additional Information: A New and Improved rh OSM is Now Available! It is HEK293 expressed and competitively priced!
• Details of Functionality: Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is 0.05-0.3 ng/mL.
• Source: E. coli-derived human Oncostatin M/OSM protein
  Ala26-Arg221
• Accession #: P13725
• Protein/Peptide Type: Recombinant Proteins
• Gene: OSM
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 22 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Oncostatin M (OSM) Protein, CF

• MGC20461
• oncostatin M
• oncostatin-M
• OSM

Background

OSM is a cytokine originally isolated from medium conditioned by PMA-treated U-937 human histiocytic leukemia cells based on its ability to inhibit growth of A375 melanoma cells. The human OSM cDNA encodes a 252 amino acid pre-pro-OSM polypeptide with a 25 residue hydrophobic signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 196 residue mature form of OSM. Although both mature and pro-OSM are equally active in radio-receptor assays, the mature OSM is 5- to 60-fold more active in growth inhibition assays. Thus, proteolytic processing of the pro-OSM peptide may be important in regulating the in vivo activities of OSM.

OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. The gp130, a signal transducing component ( beta  subunit) of the IL-6, LIF and CNTF receptor complexes, was identified as a low-affinity OSM receptor that does not transduce OSM signals. The low affinity LIF receptor (LIF R, a gp130-related protein) has now been identified to be a component of a high-affinity OSM receptor that will transduce OSM signals. Since OSM is also active on cells that do not express LIF R, a specific OSM receptor that does not involve LIF R must also exist. Besides its growth inhibitory activities on human A375 melanoma and mouse M1 myeloid leukemic cells, as well as on other solid tumor cells, OSM also has growth stimulatory activities on normal fibroblasts, AIDS-Kaposi’s sarcoma cells, and a human erythroleukemia cell line, TF-1. Other OSM-mediated activities reported to date include: stimulation of plasminogen activator activity in cultured bovine aortic endothelial cells; regulation of IL-6 expression in human endothelial cells; and stimulation of LDL uptake and up-regulation of cell surface LDL receptors in HepG2 cells.

Publications for Oncostatin M/OSM (295-OM/CF)(73)

Publications using 295-OM/CF

• A Alexanova, E Raitoharju, J Valtonen, K Aalto-Setä, LE Viiri Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism Scientific Reports, 2023-01-30;13(1):1706. 2023-01-30 [PMID: 36717592] (Differentiation, Differentiation, Human)
• A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Nature Cell Biology, 2022-10-06;0(0):. 2022-10-06 [PMID: 36202974] (Bioassay, Human)
• J Krumm, K Sekine, P Samaras, A Brazovskaj, M Breunig, R Yasui, A Kleger, H Taniguchi, M Wilhelm, B Treutlein, JG Camp, B Kuster High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development Cell Reports, 2022-03-29;38(13):110604. 2022-03-29 [PMID: 35354033] (Bioassay, Human)
• X Wang, Y Xiang, Y Yu, R Wang, Y Zhang, Q Xu, H Sun, ZA Zhao, X Jiang, X Wang, X Lu, D Qin, Y Quan, J Zhang, N Shyh-Chang, H Wang, N Jing, W Xie, L Li Formative pluripotent stem cells show features of epiblast cells poised for gastrulation Cell Research, 2021-02-19;0(0):. 2021-02-19 [PMID: 33608671] (Bioassay, Mouse)
• PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, R Linares-Sa, JG Heffler, N Sayed, D Thomas, Q Wang, LJ Stanton, K Bedi, MP Morley, TP Cappola, AT Owens, KB Margulies, DB Frank, JC Wu, DJ Rader, W Yang, BL Prosser, K Musunuru, R Jain Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes Cell Stem Cell, 2021-02-01;0(0):. 2021-02-01 [PMID: 33529599] (Bioassay, Human)
• F Michielin, GG Giobbe, C Luni, Q Hu, I Maroni, MR Orford, A Manfredi, L Di Filippo, AL David, D Cacchiarel, P De Coppi, S Eaton, N Elvassore The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs Cell Rep, 2020-12-01;33(9):108453. 2020-12-01 [PMID: 33264615] (Bioassay, Human)
• X Gao, R Li, P Cahan, Y Zhao, JJ Yourick, RL Sprando Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study Stem Cell Res Ther, 2020-09-11;11(1):393. 2020-09-11 [PMID: 32917265] (Cell Culture, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)
• L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)
• PA Subramani, N Vartak-Sha, S Sreekumar, P Mathur, B Nayer, S Dakhore, SK Basavanna, DM Kalappa, RV Krishnamur, B Mukhi, P Mishra, N Yoshida, SK Ghosh, R Shandil, S Narayanan, B Campo, K Hasegawa, AR Anvikar, N Valecha, V Sundaramur Plasmodium vivax liver stage assay platforms using Indian clinical isolates Malar. J., 2020-06-22;19(1):214. 2020-06-22 [PMID: 32571333] (Bioassay, Human)
• NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells Nat. Biotechnol., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094658] (cells, Human)
• MA Phillips, A Cánovas, MA Rea, A Islas-Trej, JF Medrano, B Durbin-Joh, DM Rocke, RH Rice Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes Sci Rep, 2020-02-19;10(1):2890. 2020-02-19 [PMID: 32076005] (Bioassay, Human)
• Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells Nat. Immunol., 2020-02-17;21(3):274-286. 2020-02-17 [PMID: 32066947] (Cell Culture, Human)
• K Fujimoto, A Shioi, Y Miki, Y Kakutani, T Morioka, T Shoji, M Emoto, M Inaba Adenosine Attenuates Aortic Smooth Muscle Cell Calcification through A3 Adenosine Receptor Tohoku J. Exp. Med., 2019-12-01;249(4):275-283. 2019-12-01 [PMID: 31875581] (Bioassay, Human)
• D Parashar, A Geethadevi, MR Aure, J Mishra, J George, C Chen, MK Mishra, A Tahiri, W Zhao, B Nair, Y Lu, LS Mangala, C Rodriguez-, G Lopez-Bere, AKS Camara, M Liang, JS Rader, R Ramchandra, M You, AK Sood, VN Kristensen, GB Mills, S Pradeep, P Chaluvally miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Cell Rep, 2019-12-24;29(13):4389-4406.e10. 2019-12-24 [PMID: 31875548] (Cell Culture, Human)
• F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore In vitro metabolic zonation through oxygen gradient on a chip Sci Rep, 2019-09-19;9(1):13557. 2019-09-19 [PMID: 31537830] (Bioassay, Human)
• RE Jones, A Salhotra, KS Robertson, RC Ransom, DS Foster, HN Shah, N Quarto, DC Wan, MT Longaker Skeletal Stem Cell-Schwann Cell Circuitry in Mandibular Repair Cell Rep, 2019-09-10;28(11):2757-2766.e5. 2019-09-10 [PMID: 31509739] (In Vivo, Mouse)
• JM Segal, D Kent, DJ Wesche, SS Ng, M Serra, B Oulès, G Kar, G Emerton, SJI Blackford, S Darmanis, R Miquel, TV Luong, R Yamamoto, A Bonham, W Jassem, N Heaton, A Vigilante, A King, R Sancho, S Teichmann, SR Quake, H Nakauchi, ST Rashid Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors Nat Commun, 2019-07-26;10(1):3350. 2019-07-26 [PMID: 31350390] (Bioassay, Human)
• H Okada, C Nakanishi, S Yoshida, M Shimojima, J Yokawa, M Mori, H Tada, T Yoshimuta, K Hayashi, T Yamano, R Hanayama, M Yamagishi, MA Kawashiri Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia Sci Rep, 2019-03-18;9(1):4695. 2019-03-18 [PMID: 30886174] (Bioassay, Human)
• L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 2019-01-21;10(1):364. 2019-01-21 [PMID: 30664750] (Bioassay, Human)
• J Kim, Y Kim, J Choi, H Jung, K Lee, J Kang, N Park, YA Rim, Y Nam, JH Ju Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis Stem Cell Res Ther, 2018-12-29;9(1):357. 2018-12-29 [PMID: 30594247] (Bioassay, Human)
• S Müller, A Versini, F Sindikubwa, G Belthier, S Niyomchon, J Pannequin, L Grimaud, T Cañeque, R Rodriguez Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells PLoS ONE, 2018-11-06;13(11):e0206764. 2018-11-06 [PMID: 30399175] (Bioassay, Human)
• D van Keulen, MG Pouwer, G Pasterkamp, AJ van Gool, MD Sollewijn, HMG Princen, D Tempel Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice PLoS ONE, 2018-10-01;13(10):e0204911. 2018-10-01 [PMID: 30273401] (Bioassay, Human)
• A Skrzypczyk, S Kehr, I Krystel, SH Bernhart, S Giri, A Bader, PF Stadler Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes Stem Cells Int, 2018-08-19;2018(0):5692840. 2018-08-19 [PMID: 30210551] (Bioassay, Human)
• H Ayabe, T Anada, T Kamoya, T Sato, M Kimura, E Yoshizawa, S Kikuchi, Y Ueno, K Sekine, JG Camp, B Treutlein, A Ferguson, O Suzuki, T Takebe, H Taniguchi Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling Stem Cell Reports, 2018-07-19;0(0):. 2018-07-19 [PMID: 30033085] (Bioassay, Human)
• M Yanez Arte, T Kjellman, S Bartesaghi, S Wallin, X Wu, AJ Kvist, A Dabkowska, N Székely, A Radulescu, J Bergenholt, L Lindfors Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles Proc. Natl. Acad. Sci. U.S.A., 2018-03-27;0(0):. 2018-03-27 [PMID: 29588418] (Bioassay, Human)
• J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications Cell, 2018-03-22;0(0):. 2018-03-22 [PMID: 29576452] (Bioassay, Squirrel)
• WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver Cell Transplant, 2017-12-01;26(12):1868-1877. 2017-12-01 [PMID: 29390880] (Bioassay, Mouse)
• YJ Han, YH Kang, SB Shivakumar, D Bharti, YB Son, YH Choi, WU Park, JH Byun, GJ Rho, BW Park Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro Int J Med Sci, 2017-11-02;14(13):1418-1429. 2017-11-02 [PMID: 29200956] (Bioassay, Human)
• T Oike, Y Sato, T Kobayashi, K Miyamoto, S Nakamura, Y Kaneko, S Kobayashi, K Harato, H Saya, M Matsumoto, M Nakamura, Y Niki, T Miyamoto Stat3 as a potential therapeutic target for rheumatoid arthritis Sci Rep, 2017-09-08;7(1):10965. 2017-09-08 [PMID: 28887478] (Bioassay, Human)
• JG Camp, K Sekine, T Gerber, H Loeffler-W, H Binder, M Gac, S Kanton, J Kageyama, G Damm, D Seehofer, L Belicova, M Bickle, R Barsacchi, R Okuda, E Yoshizawa, M Kimura, H Ayabe, H Taniguchi, T Takebe, B Treutlein Multilineage communication regulates human liver bud development from pluripotency Nature, 2017-06-14;0(0):. 2017-06-14 [PMID: 28614297] (Bioassay, Human)
• Q Li, AP Hutchins, Y Chen, S Li, Y Shan, B Liao, D Zheng, X Shi, Y Li, WY Chan, G Pan, S Wei, X Shu, D Pei A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes Nat Commun, 2017-05-03;8(0):15166. 2017-05-03 [PMID: 28466868] (Bioassay, Human)
• EE Pashos, Y Park, X Wang, A Raghavan, W Yang, D Abbey, DT Peters, J Arbelaez, M Hernandez, N Kuperwasse, W Li, Z Lian, Y Liu, W Lv, SL Lytle-Gabb, DH Marchadier, P Rogov, J Shi, KJ Slovik, IM Stylianou, L Wang, R Yan, X Zhang, S Kathiresan, SA Duncan, TS Mikkelsen, EE Morrisey, DJ Rader, CD Brown, K Musunuru Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci Cell Stem Cell, 2017-04-06;20(4):558-570.e10. 2017-04-06 [PMID: 28388432] (Bioassay, Human)
• G Chandrika, K Natesh, D Ranade, A Chugh, P Shastry Mammalian target of rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by phorbol-myristate-acetate and oncostatin-M in glioblastoma cells Tumour Biol., 2017-03-01;39(3):1010428317695. 2017-03-01 [PMID: 28351321] (Bioassay, Human)
• BC Narmada, YT Goh, H Li, S Sinha, H Yu, C Cheung Human Stem Cell-Derived Endothelial-Hepatic Platform for Efficacy Testing of Vascular-Protective Metabolites from Nutraceuticals Stem Cells Transl Med, 2016-10-07;6(3):851-863. 2016-10-07 [PMID: 28297582] (Bioassay, Human)
• Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Sci Rep, 2017-01-25;7(0):41238. 2017-01-25 [PMID: 28120901] (Bioassay, Human)
• Yan-Jin Zhang Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Nsp5 by Inducing STAT3 Degradation J. Virol., 2017-01-18;0(0):. 2017-01-18 [PMID: 27881658] (Bioassay, Porcine)
• Danièle Noel Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFN?-Primed Equine Mesenchymal Stem Cells Front Immunol, 2016-09-27;7(0):392. 2016-09-27 [PMID: 27729913] (Bioassay, Equine)
• Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow Nat Cell Biol, 2016-09-19;18(10):1078-1089. 2016-09-19 [PMID: 27642788] (Bioassay, Human)
• Murine Oncostatin M acts via Leukemia Inhibitory Factor Receptor to phosphorylate STAT3 but not STAT1, an effect that protects bone mass J Biol Chem, 2016-08-18;0(0):. 2016-08-18 [PMID: 27539849] (Bioassay, Mouse)
• Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus Sci Rep, 2016-07-08;6(0):29358. 2016-07-08 [PMID: 27386799] (Bioassay, Human)
• Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, Morrisey E Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells. PLoS ONE, 2015-08-17;10(8):e0134995. 2015-08-17 [PMID: 26281015] (Bioassay, Human)
• Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res, 2015-02-07;16(0):14. 2015-02-07 [PMID: 25849622] (Bioassay, Human)
• Nagiec M, Skepner A, Negri J, Eichhorn M, Kuperwasser N, Comer E, Muncipinto G, Subramanian A, Clish C, Musunuru K, Duvall J, Foley M, Perez J, Palmer M Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS ONE, 2015-03-26;10(3):e0120295. 2015-03-26 [PMID: 25811180] (Bioassay, Human)
• Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, Hauser K, Yao Z, Boyce B, Kordula T RelB/p50 complexes regulate cytokine-induced YKL-40 expression. J Immunol, 2015-02-13;194(6):2862-70. 2015-02-13 [PMID: 25681350] (Bioassay, Human)
• Czysz , Katherin, Minger , Stephen, Thomas , Nick DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE, 2015-02-06;10(2):e0117689. 2015-02-06 [PMID: 25659159] (Bioassay, Human)
• Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J The expression and regulation of chemerin in the epidermis. PLoS ONE, 2015-02-06;10(2):e0117830. 2015-02-06 [PMID: 25659101] (Bioassay, Human)
• Ehlting C, Bohmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, Knoefel W, Schulte Am Esch J, Haussinger D, Bode J Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2. Cell Signal, 2015-01-03;27(3):555-67. 2015-01-03 [PMID: 25562430] (Bioassay, Human)
• Gao W, Zhou P, Ma X, Tschudy-Seney B, Chen J, Magner N, Revzin A, Nolta J, Zern M, Duan Y Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro. PLoS ONE, 2014-11-13;9(11):e112698. 2014-11-13 [PMID: 25393427] (Bioassay, Human)
• Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuede C, Muller C, Valet P, Gespach C, Bracke M, Cocquyt V, Denys H, De Wever O Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res, 2014-09-24;74(23):6806-19. 2014-09-24 [PMID: 25252914] (Bioassay, Human)
• Pini L, Tiberio L, Venkatesan N, Bezzi M, Corda L, Luisetti M, Ferrarotti I, Malerba M, Lomas D, Janciauskiene S, Vizzardi E, Modina D, Schiaffonati L, Tantucci C The role of bronchial epithelial cells in the pathogenesis of COPD in Z-alpha-1 antitrypsin deficiency. Respir Res, 2014-09-14;15(0):112. 2014-09-14 [PMID: 25218041] (Bioassay, Human)
• Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014-07-10;9(7):e101937. 2014-07-10 [PMID: 25010647] (Bioassay, Human)
• Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine, 2014-04-22;68(2):101-9. 2014-04-22 [PMID: 24767864] (Bioassay, Human)
• Takebe , Takanori, Zhang , Ran-Ran, Koike , Hiroyuki, Kimura , Masaki, Yoshizawa , Emi, Enomura , Masahiro, Koike , Naoto, Sekine , Keisuke, Taniguchi , Hideki Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc, 2014-01-23;9(2):396-409. 2014-01-23 [PMID: 24457331] (Bioassay, Human)
• Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports, 2013-10-03;1(4):322-35. 2013-10-03 [PMID: 24319667] (Bioassay, Human)
• Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision. Development, 2013-11-27;141(1):91-100. 2013-11-27 [PMID: 24284203] (Bioassay, Human)
• van 't Wout E, Dickens J, van Schadewijk A, Haq I, Kwok H, Ordonez A, Murphy G, Stolk J, Lomas D, Hiemstra P, Marciniak S Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z alpha1-antitrypsin. Hum Mol Genet, 2013-10-04;23(4):929-41. 2013-10-04 [PMID: 24097797] (Bioassay, Human)
• Hannan , Nicholas, Segeritz , Charis-P, Touboul , Thomas, Vallier , Ludovic Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc, 2013-01-01;8(2):430-7. 2013-01-01 [PMID: 23370178] (Bioassay, Human)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-08-11;5(8):e12101. 2010-08-11 [PMID: 20711405] (Cell Culture, Human)
• Larsen JV, Hansen M, Moller B, Madsen P, Scheller J, Nielsen M, Petersen CM Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol. Cell. Biol., 2010-06-28;17(0):4175. 2010-06-28 [PMID: 20584990] (Bioassay, Human)
• Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis. J. Immunol., 2010-03-24;184(0):5263-70. 2010-03-24 [PMID: 20335534] (Bioassay, Human)
• Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int. J. Cancer, 2009-07-15;125(2):367-73. 2009-07-15 [PMID: 19378341] (Bioassay, Human)
• Rahmoun M, Moles JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pene J Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J. Invest. Dermatol., 2008-10-09;129(3):671-81. 2008-10-09 [PMID: 18843289] (Bioassay, Human)
• Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human)
• Brechter AB, Lerner UH Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum., 2007-03-01;56(3):910-23. 2007-03-01 [PMID: 17328065] (Bioassay, Human)
• Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J. Immunol., 2006-12-01;177(11):7665-72. 2006-12-01 [PMID: 17114436] (Bioassay, Human)
• Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum., 2006-10-01;54(10):3152-62. 2006-10-01 [PMID: 17009243] (Bioassay, Human)
• Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro. Int. J. Dev. Biol., 2006-01-01;50(7):645-52. 2006-01-01 [PMID: 16892178] (Bioassay, Human)
• He W, Gong K, Smith DK, Ip NY The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling. FEBS Lett., 2005-08-15;579(20):4317-23. 2005-08-15 [PMID: 16051226] (Binding Assay, Bioassay, Human)
• Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (Bioassay, ELISA (Standard), Human)
• Scaffidi AK, 2019, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. 3821-3828, 2002-07-01;136(5):793-801. 2002-07-01 [PMID: 12086989] (Bioassay, Human)
• Savarese TM, Campbell CL, McQuain C, Mitchell K, Guardiani R, Quesenberry PJ, Nelson BE Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas. Cytokine, 2002-03-21;17(6):324-34. 2002-03-21 [PMID: 12061840] (Bioassay, Human)

Bioinformatics

• Gene Symbol: OSM
• Uniprot:
  • P13725()