Recombinant Human IL-8/CXCL8 Protein

Recombinant HumanIL-8/CXCL8 (Catalog # 208-IL) chemoattracts the BaF3 mouse pro-B cell line transfected with human CXCR2. The ED50 for this effect is 0.5-2.5 ng/mL.

1 μg/lane of Recombinant HumanIL-8/CXCL8 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 8 kDa.

• Reactivity: Hu
• Applications: Bioactivity

Recombinant Human IL-8/CXCL8 Protein Summary

• Details of Functionality: Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR2. The ED₅₀ for this effect is 0.5-2.5 ng/mL.
• Source: E. coli-derived human IL-8/CXCL8 protein
  Ser28-Ser99
• Accession #: P10145.1
• N-terminal Sequence: Ser28
• Protein/Peptide Type: Recombinant Proteins
• Gene: CXCL8
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Endotoxin Note: <0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 8 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
• Reconstitution Instructions: Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-8/CXCL8 Protein

• 3-10C
• AMCF-I
• C-X-C motif chemokine 8
• CXCL8
• CXCL8SCYB8
• Emoctakin
• GCP1
• GCP-1TSG-1
• IL8
• IL-8
• interleukin 8
• K60
• LAI
• LECT
• LUCT
• LYNAP
• MDNCF
• MDNCFb-ENAP
• member 8
• MONAP
• MONAPGCP1
• NAF
• NAP1
• NAP-1NAP1
• NCF
• Neutrophil-activating protein 1
• Protein 3-10C
• T cell chemotactic factor
• T-cell chemotactic factor
• TCF
• TSG1

Background

Interleukin-8 (IL-8), also known as CXCL8, GCP-1, and NAP-1, is a widely expressed proinflammatory member of the CXC family of chemokines. Near its N-terminus, this 8-9 kDa chemokine contains an ELR motif which is important for its angiogenic properties (1). IL-8/CXCL8 can associate into a homodimer or a heterodimer with CXCL4/PF4 (2), and it can also interact with matrix and cell surface glycosaminoglycans (3). Mature human IL-8/CXCL8 shares 65%-69% amino acid (aa) sequence identiity with canine, feline, and porcine IL-8/CXCL8 (4). There is no IL-8/CXCL8 gene counterpart in rodent. N-terminal truncation by multiple proteases generates a range of shorter forms, and an alternative splice form of human IL-8/CXCL8 carries an eleven aa substitution at the C-terminus (5). The bioactivity of IL-8/CXCL8 is regulated by these truncations, by IL-8/CXCL8 citrullination at Arg5 (N-terminal to the ELR motif) (6), and by the decoy receptor DARC (7). IL-8/CXCL8 effects are mediated through CXCR1/IL-8 RA, which is also used by CXCL6, and through CXCR2/IL-8 RB, which is used by multiple CXC chemokines (1). CXCR1 and CXCR2 associate into functional homodimers and heterodimers with each other (8). Through both CXCR1 and CXCR2, CXCL8 promotes neutrophil adhesion to the vascular endothelium and migration to sites of inflammation (9). It triggers the antimicrobial activation of neutrophils through CXCR1 (10). CXCL8 also binds to Serpin A1/alpha-1 Antitrypsin, and this prevents IL-8/CXCL8 interaction with CXCR1 (11). IL-8/CXCL8 is upregulated in atherosclerotic lesions and other cardiac pathologies where it exacerbates inflammatory tissue damage (12). In addition, it induces VEGF expression, vascular endothelial cell proliferation, angiogenesis, and tumor cell invasiveness (13-16).

1. Lazennec, G. and A. Richmond (2010) Trends Mol. Med. 16:133.
2. Nesmelova, I.V. et al. (2005) J. Biol. Chem. 280:4948.
3. Pichert, A. et al. (2012) Biomatter 2:142.
4. Schmid, J. and C. Weissmann (1987) J. Immunol. 139:250.
5. Mortier, A. et al. (2008) Pharmacol. Ther. 120:197.
6. Proost, P. et al. (2008) J. Exp. Med. 205:2085.
7. Neote, K. et al. (1994) Blood 84:44.
8. Munoz, L.M. et al. (2009) J. Immunol. 183:7337.
9. Gerszten, R.E. et al. (1999) Nature 398:718.
10. Jones, S.A. et al. (1996) Proc. Natl. Acad. Sci. USA 93:6682.
11. Bergin, D.A. et al. (2010) J. Clin. Invest. 120:4236.
12. Apostolakis, S. et al. (2009) Cardiovasc. Res. 84:353.
13. Martin, D. et al. (2009) J. Biol. Chem. 284:6038.
14. Li, A. et al. (2005) Angiogenesis 8:63.
15. Waugh, D.J. and C. Wilson (2008) Clin. Cancer Res. 14:6735.
16. Fernando, R.I. et al. (2011) Cancer Res. 71:5296.

Publications for CXCL8/IL-8 (208-IL)(129)

Publications using 208-IL

• Rawal, KN;Degorre, C;Tofilon, PJ; Glioblastoma Cells Induce Neuron Loss In Vivo and In Vitro Cancers 2025-08-28 [PMID: 40940913] (Bioassay, Human)
• Reedy, JL;Jensen, KN;Crossen, AJ;Basham, KJ;Ward, RA;Reardon, CM;Brown Harding, H;Hepworth, OW;Simaku, P;Kwaku, GN;Tone, K;Willment, JA;Reid, DM;Stappers, MHT;Brown, GD;Rajagopal, J;Vyas, JM; Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing Nature communications 2024-07-10 [PMID: 38987270] (Bioassay, Human)
• Cho, YE;Kim, Y;Kim, SJ;Lee, H;Hwang, S; Overexpression of Interleukin-8 Promotes the Progression of Fatty Liver to Nonalcoholic Steatohepatitis in Mice International journal of molecular sciences 2023-10-23 [PMID: 37895168] (Bioassay, Human)
• Binder, V;Li, W;Faisal, M;Oyman, K;Calkins, DL;Shaffer, J;Teets, EM;Sher, S;Magnotte, A;Belardo, A;Deruelle, W;Gregory, TC;Orwick, S;Hagedorn, EJ;Perlin, JR;Avagyan, S;Lichtig, A;Barrett, F;Ammerman, M;Yang, S;Zhou, Y;Carson, WE;Shive, HR;Blachly, JS;Lapalombella, R;Zon, LI;Blaser, BW; Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C Cell reports 2023-05-18 [PMID: 37209097] (Bioassay, Human)
• Pajulas, A;Fu, Y;Cheung, CCL;Chu, M;Cannon, A;Alakhras, N;Zhang, J;Ulrich, BJ;Nelson, AS;Zhou, B;Kaplan, MH; Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation Mucosal immunology 2023-05-10 [PMID: 37172907] (Bioassay, Mouse)
• LJ Pallett, L Swadling, M Diniz, AA Maini, M Schwabenla, AD Gasull, J Davies, S Kucykowicz, JK Skelton, N Thomas, NM Schmidt, OE Amin, US Gill, KA Stegmann, AR Burton, E Stephenson, G Reynolds, M Whelan, J Sanchez, R de Maeyer, C Thakker, K Suveizdyte, I Uddin, AM Ortega-Pri, C Grant, F Froghi, G Fusai, S Lens, S Pérez-Del-, W Al-Akkad, G Mazza, M Noursadegh, A Akbar, PTF Kennedy, BR Davidson, M Prinz, BM Chain, M Haniffa, DW Gilroy, M Dorner, B Bengsch, A Schurich, MK Maini Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS Nature, 2023-01-25;614(7947):334-342. 2023-01-25 [PMID: 36697826] (Bioassay, Human)
• R Islam, J Mishra, NS Polavaram, S Bhattachar, Z Hong, S Bodas, S Sharma, A Bouska, T Gilbreath, AM Said, LM Smith, BA Teply, MH Muders, SK Batra, K Datta, S Dutta Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance Oncogene, 2022-07-19;40(3):111097. 2022-07-19 [PMID: 35858551] (Bioassay, Human)
• L Wen, A Marki, Z Wang, M Orecchioni, J Makings, M Billitti, E Wang, SSA Suthahar, K Kim, WB Kiosses, Z Mikulski, K Ley A humanized beta2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in�vivo Cell Reports, 2022-05-31;39(9):110876. 2022-05-31 [PMID: 35649374] (Bioassay, Human)
• A Conod, M Silvano, A Ruiz I Alt On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm Cell Reports, 2022-03-08;38(10):110490. 2022-03-08 [PMID: 35263600] (Bioassay, Human)
• ML Capitano, Y Sammour, J Ropa, M Legendre, N Mor-Vaknin, DM Markovitz DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Galphai signaling Journal of leukocyte biology, 2022-02-08;0(0):. 2022-02-08 [PMID: 35137444] (Bioassay, Mouse)
• M Lesouhaiti, M Gregoire, A Gacouin, V Coirier, A Frerou, C Piau, V Cattoir, E Dumontet, M Revest, P Tattevin, A Roisne, JP Verhoye, E Flecher, Y Le Tulzo, K Tarte, JM Tadié Neutrophil function and bactericidal activity against Staphylococcus aureus after cardiac surgery with cardiopulmonary bypass Journal of leukocyte biology, 2021-08-23;0(0):. 2021-08-23 [PMID: 34425029] (Bioassay, Human)
• J Lee, JA Choi, HH Ju, JE Kim, SY Paik, PV Rao Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells Scientific Reports, 2021-07-22;11(1):14950. 2021-07-22 [PMID: 34294770] (Bioassay, Human)
• N Kashiwagi, F Saito, H Maegawa, K Kaneda Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - In vitro and in vivo results Cytokine, 2021-01-01;139(0):155410. 2021-01-01 [PMID: 33395614] (Bioassay, Human)
• SJ Evani, SLR Karna, J Seshu, KP Leung Pirfenidone regulates LPS mediated activation of neutrophils Sci Rep, 2020-11-17;10(1):19936. 2020-11-17 [PMID: 33203891] (Bioassay, Human)
• L Rankin, S Gouveia-Fi, KP Danielsson, CJ Fowler Relative Deficiency of Anti-Inflammatory N-Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus Biomedicines, 2020-11-06;8(11):. 2020-11-06 [PMID: 33172176] (Cell Culture, Human)
• D Biasci, M Smoragiewi, CM Connell, Z Wang, Y Gao, JED Thaventhir, B Basu, L Magiera, TI Johnson, L Bax, A Gopinathan, C Isherwood, FA Gallagher, M Pawula, I Hudecova, D Gale, N Rosenfeld, P Barmpounak, EC Popa, R Brais, E Godfrey, F Mir, FM Richards, DT Fearon, T Janowitz, DI Jodrell CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response Proc Natl Acad Sci U S A, 2020-10-30;0(0):. 2020-10-30 [PMID: 33127761] (Bioassay, Human)
• KA Meerschaer, PC Adelman, RL Friedman, KM Albers, HR Koerber, BM Davis Unique molecular characteristics of visceral afferents arising from different levels of the neuraxis: location of afferent somata predicts function and stimulus detection modalities J. Neurosci., 2020-08-19;0(0):. 2020-08-19 [PMID: 32817244] (Bioassay, Cell Culture, Mouse)
• L Bornemann, M Schuster, S Schmitz, C Sobczak, C Bessen, SF Merz, KH Jöckel, T Haverkamp, M Gunzer, JR Göthert Defective migration and dysmorphology of neutrophil granulocytes in atypical chronic myeloid leukemia treated with ruxolitinib BMC Cancer, 2020-07-13;20(1):650. 2020-07-13 [PMID: 32660441] (Bioassay, Human)
• MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES) Biomed J, 2020-05-29;0(0):. 2020-05-29 [PMID: 32651134] (Bioassay, Human)
• KW Kang, SJ Lee, JH Kim, BH Lee, SJ Kim, Y Park, BS Kim Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization BMC Cancer, 2020-07-02;20(1):619. 2020-07-02 [PMID: 32615949] (Bioassay, Human)
• H Kikuchi, N Maishi, DA Annan, M Towfik Ala, R Ibrahim Ha, M Sato, M Morimoto, R Takeda, K Ishizuka, R Matsumoto, T Akino, K Tsuchiya, T Abe, T Osawa, N Miyajima, S Maruyama, T Harabayash, M Azuma, K Yamashiro, K Ameda, A Kashiwagi, Y Matsuno, Y Hida, N Shinohara, K Hida Chemotherapy-induced IL-8 upregulates MDR1/ABCB1 in tumor blood vessels and results in unfavorable outcome Cancer Res., 2020-06-14;0(0):. 2020-06-14 [PMID: 32536602] (Bioassay, Human)
• T Yamanaka, N Harimoto, T Yokobori, R Muranushi, K Hoshino, K Hagiwara, D Gantumur, T Handa, N Ishii, M Tsukagoshi, T Igarashi, H Tanaka, A Watanabe, N Kubo, K Araki, K Shirabe Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts Br. J. Cancer, 2020-02-04;0(0):. 2020-02-04 [PMID: 32015511] (Cell Culture, Human)
• JY Ko, WS Lian, TC Tsai, YS Chen, CK Hsieh, CW Kuo, FS Wang MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness Int J Mol Sci, 2019-11-15;20(22):. 2019-11-15 [PMID: 31731750] (Cell Culture, Human)
• VS Brok-Volch, DA Bennin, K Suknuntha, LC Klemm, A Huttenloch, I Slukvin Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA Stem Cell Reports, 2019-11-07;13(6):1099-1110. 2019-11-07 [PMID: 31708474] (Bioassay, Human)
• F Caccuri, A Bugatti, S Corbellini, S Roversi, A Zani, P Mazzuca, S Marsico, A Caruso, C Giagulli The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) Int J Mol Sci, 2019-10-24;20(21):. 2019-10-24 [PMID: 31653015] (Bioassay, Human)
• H Sun, Z Fan, AR Gingras, MA Lopez-Rami, MH Ginsberg, K Ley Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling J. Leukoc. Biol., 2019-09-01;0(0):. 2019-09-01 [PMID: 31475386] (Bioassay, Human)
• ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 2019-05-20;130(0):2555-2570. 2019-05-20 [PMID: 31107242] (Bioassay, Human, Porcine)
• TA Sebrell, M Hashimi, B Sidar, R Wilkinson, L Kirpotina, MT Quinn, Z Malkoç, PJ Taylor, JN Wilking, D Bimczok A Novel Gastric Spheroid Co-Culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium Cell Mol Gastroenterol Hepatol, 2019-03-13;0(0):. 2019-03-13 [PMID: 30878664] (Bioassay, Human)
• F Coperchini, L Croce, M Denegri, O Awwad, ST Ngnitejeu, M Muzza, V Capelli, F Latrofa, L Persani, L Chiovato, M Rotondi The BRAF-inhibitor PLX4720 inhibits CXCL8 secretion in BRAFV600E mutated and normal thyroid cells: a further anti-cancer effect of BRAF-inhibitors Sci Rep, 2019-03-13;9(1):4390. 2019-03-13 [PMID: 30867499] (Bioassay, Human)
• Y Tabei, H Fukui, A Nishioka, Y Hagiwara, K Sato, T Yoneda, T Koyama, M Horie Effect of iron overload from multi walled carbon nanotubes on neutrophil-like differentiated HL-60 cells Sci Rep, 2019-02-18;9(1):2224. 2019-02-18 [PMID: 30778158] (Bioassay, Human)
• L Björkman, K Christenso, L Davidsson, J Mårtensson, F Amirbeagi, A Welin, H Forsman, A Karlsson, C Dahlgren, J Bylund Neutrophil recruitment to inflamed joints can occur without cellular priming J. Leukoc. Biol., 2018-12-20;0(0):. 2018-12-20 [PMID: 30570778] (Bioassay, Human)
• C Trapella, R Rizzo, S Gallo, A Alogna, D Bortolotti, F Casciano, G Zauli, P Secchiero, R Voltan HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts Sci Rep, 2018-12-05;8(1):17665. 2018-12-05 [PMID: 30518946] (Bioassay, Human)
• DB Bartlett, LH Willis, CA Slentz, A Hoselton, L Kelly, JL Huebner, VB Kraus, J Moss, MJ Muehlbauer, G Spielmann, WE Kraus, JM Lord, KM Huffman Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study Arthritis Res. Ther., 2018-06-14;20(1):127. 2018-06-14 [PMID: 29898765] (Bioassay, Human)
• JA Fraser, S Kemp, L Young, M Ross, M Prach, GR Hutchison, E Malone Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations Sci Rep, 2018-05-14;8(1):7506. 2018-05-14 [PMID: 29760395] (ELISA (Standard))
• S Conroy, FAE Kruyt, M Wagemakers, KPL Bhat, WFA den Dunnen IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma Oncotarget, 2018-02-28;9(21):15721-15731. 2018-02-28 [PMID: 29644004] (Bioassay, Human)
• T Barliya, R Dardik, Y Nisgav, M Dachbash, D Gaton, G Kenet, R Ehrlich, D Weinberger, T Livnat Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients Mol. Vis., 2017-12-13;23(0):922-932. 2017-12-13 [PMID: 29296072] (In Vivo, Mouse)
• J Wang, M Kollarik, F Ru, H Sun, B McNeil, X Dong, G Stephens, S Korolevich, P Brohawn, R Kolbeck, B Undem Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing PLoS ONE, 2017-10-05;12(10):e0185985. 2017-10-05 [PMID: 28982197] (Bioassay, Mouse)
• KM Krawczyk, H Nilsson, R Allaoui, D Lindgren, M Arvidsson, K Leandersso, ME Johansson Papillary renal cell carcinoma-derived chemerin, IL-8, and CXCL16 promote monocyte recruitment and differentiation into foam-cell macrophages Lab. Invest., 2017-07-31;97(11):1296-1305. 2017-07-31 [PMID: 28759013] (Bioassay, Human)
• L Shen, P Zhang, S Zhang, L Xie, L Yao, W Lang, J Lian, W Qin, M Zhang, L Ji C-X-C motif chemokine ligand 8 promotes endothelial cell homing via the Akt-signal transducer and activator of transcription pathway to accelerate healing of ischemic and hypoxic skin ulcers Exp Ther Med, 2017-04-05;13(6):3021-3031. 2017-04-05 [PMID: 28587375] (Bioassay, Human)
• J Arebro, S Ekstedt, E Hjalmarsso, O Winqvist, S Kumlien Ge, LO Cardell A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification Sci Rep, 2017-03-08;7(0):43568. 2017-03-08 [PMID: 28272395] (Bioassay, Human)
• C Rydberg Mi, Å Kågedal, S Kumlien Ge, O Winqvist, R Uddman, R Razavi, E Munck-Wikl, L Olaf Carde NET-producing CD16(high) CD62L(dim) Neutrophils Migrate to Tumor Sites and Predict Improved Survival in Patients with HNSCC Int. J. Cancer, 2017-03-11;0(0):. 2017-03-11 [PMID: 28247912] (Bioassay, Human)
• Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases Cell Death Dis, 2016-12-29;7(12):e2565. 2016-12-29 [PMID: 28032864] (Bioassay, Human)
• Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling Sci Rep, 2016-12-19;6(0):39190. 2016-12-19 [PMID: 27991524] (Bioassay, Human)
• Benjamin Malard Adsorption as a Contributor for Inflammatory Mediators Removal by Different Hemofiltration Membranes: A Pilot Study Artif Organs, 2016-12-02;0(0):. 2016-12-02 [PMID: 27911005] (Hemofiltration Procedure, Human)
• Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking PLoS Pathog., 2016-11-02;12(11):e1005986. 2016-11-02 [PMID: 27806130] (In Vivo, Zebrafish)
• Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells. Stem Cells International, 2016-09-07;0(0):1687-966X. 2016-09-07 [PMID: 27667999] (Bioassay, Human)
• Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways PLoS ONE, 2016-08-16;11(8):e0161343. 2016-08-16 [PMID: 27529549] (Bioassay, Human)
• S Robert, T Gicquel, A Bodin, V Lagente, E Boichot Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1? or TNF-? Release from Human Hepatic Stellate Cells PLoS ONE, 2016-04-05;11(4):e0153118. 2016-04-05 [PMID: 27046197] (Bioassay, Human)
• MA Boink, S Roffel, K Nazmi, C van Montfr, JG Bolscher, A Gefen, EC Veerman, S Gibbs The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability PLoS ONE, 2016-03-28;11(3):e0152613. 2016-03-28 [PMID: 27018788] (Bioassay, Human)
• Picon-Ruiz M, Pan C, Drews-Elger K, Jang K, Besser A, Zhao D, Morata-Tarifa C, Kim M, Ince T, Azzam D, Wander S, Wang B, Ergonul B, Datar R, Cote R, Howard G, El-Ashry D, Torne-Poyatos P, Marchal J, Slingerland J Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression. Cancer Res, 2016-01-07;76(2):491-504. 2016-01-07 [PMID: 26744520] (Bioassay, Human)
• Paul F Lindholm, Neela Sivapurapu, Borko Jovanovic, André Kajdacsy-Balla Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-kappa B Activity Journal of Clinical and Cellular Immunology 2015-08-29 [PMID: 26317041] (Bioassay, Human)
• Chen L, Min L, Wang X, Zhao J, Chen H, Qin J, Chen W, Shen Z, Tang Z, Gan Q, Ruan Y, Sun Y, Qin X, Gu J Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop. Cancer Res, 2015-07-21;75(18):3832-41. 2015-07-21 [PMID: 26199092] (Bioassay, Human)
• Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat Med, 2015-04-20;21(5):530-6. 2015-04-20 [PMID: 25894825] (Bioassay, Human)
• Martin , Kayleigh, Muessel , Michelle, Pullar , Christin, Willars , Gary B, Wardlaw , Andrew J The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS ONE, 2015-02-06;10(2):e0116250. 2015-02-06 [PMID: 25659107] (Bioassay, Human)
• Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, Zalvide J The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell, 2015-02-05;14(2):274-83. 2015-02-05 [PMID: 25655101] (Bioassay, Human)
• Zariffard , M Reza, Anastos , Kathryn, French , Audrey L, Munyazesa , Elisapha, Cohen , Mardge, Landay , Alan L, Spear , Gregory Cleavage/alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS ONE, 2015-01-22;10(1):e0116911. 2015-01-22 [PMID: 25611319] (Bioassay, Human)
• Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62. 2015-01-20 [PMID: 25604685] (Bioassay, Human)
• Jung J, Lee S, Kim J, Lee S, Sung H, An J, Park Y, Kim B CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev, 2014-12-23;24(8):948-61. 2014-12-23 [PMID: 25390768] (Bioassay, Human)
• Hazeldine J, Harris P, Chapple I, Grant M, Greenwood H, Livesey A, Sapey E, Lord J Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell, 2014-04-30;13(4):690-8. 2014-04-30 [PMID: 24779584] (Bioassay, Human)
• Mamik M, Ghorpade A Chemokine CXCL8 promotes HIV-1 replication in human monocyte-derived macrophages and primary microglia via nuclear factor-kappaB pathway. PLoS ONE, 2014-03-24;9(3):e92145. 2014-03-24 [PMID: 24662979] (Bioassay, Human)
• Gharaee-Kermani M, Mehra R, Robinson D, Wei J, Macoska J Complex cellular composition of solitary fibrous tumor of the prostate. Am J Pathol, 2014-01-13;184(3):732-9. 2014-01-13 [PMID: 24434011] (Bioassay, Human)
• Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V Neutrophil microparticles modulate cytokine production by natural killer cells. Cytokine, 2013-12-16;65(2):126-9. 2013-12-16 [PMID: 24355430] (Bioassay, Human)
• Cheng X, He P, Lee T, Yao H, Li R, Shen Y High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol, 2014-01-01;184(1):141-7. 2014-01-01 [PMID: 24332014] (Bioassay, Human)
• Mondrinos M, Zhang T, Sun S, Kennedy P, King D, Wolfson M, Knight L, Scalia R, Kilpatrick L Pulmonary endothelial protein kinase C-delta (PKCdelta) regulates neutrophil migration in acute lung inflammation. Am J Pathol, 2013-11-06;184(1):200-13. 2013-11-06 [PMID: 24211111] (Bioassay, Human)
• Sukkurwala A, Martins I, Wang Y, Schlemmer F, Ruckenstuhl C, Durchschlag M, Michaud M, Senovilla L, Sistigu A, Ma Y, Vacchelli E, Sulpice E, Gidrol X, Zitvogel L, Madeo F, Galluzzi L, Kepp O, Kroemer G Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8. Cell Death Differ, 2013-06-21;21(1):59-68. 2013-06-21 [PMID: 23787997] (Bioassay, Human)
• Bai X, Feldman N, Chmura K, Ovrutsky A, Su W, Griffin L, Pyeon D, McGibney M, Strand M, Numata M, Murakami S, Gaido L, Honda J, Kinney W, Oberley-Deegan R, Voelker D, Ordway D, Chan E Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages. PLoS ONE, 2013-04-25;8(4):e61925. 2013-04-25 [PMID: 23634218] (Bioassay, Human)
• Kothari H, Rao L, Vankayalapati R, Pendurthi U Mycobacterium tuberculosis infection and tissue factor expression in macrophages. PLoS ONE, 2012-09-24;7(9):e45700. 2012-09-24 [PMID: 23029190] (Bioassay, Human)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Vujanovic , Lazar, Ballard , Wenners, Thorne , Stephen, Vujanovic , Nikola L, Butterfield , Lisa H Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10. Oncoimmunology, 2012-07-01;1(4):448-457. 2012-07-01 [PMID: 22754763] (Bioassay, Human)
• Sahlander K, Larsson K, Palmberg L Daily exposure to dust alters innate immunity. PLoS ONE, 2012-02-15;7(2):e31646. 2012-02-15 [PMID: 22355383] (ELISA (Standard))
• Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012-01-12;8(1):e1002486. 2012-01-12 [PMID: 22253598] (Bioassay, Human)
• Kinzfogl J, Hangoc G, Broxmeyer HE Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. Blood, 2011-05-31;118(3):565-75. 2011-05-31 [PMID: 21628410] (Bioassay, Human)
• Burton VJ, Butler LM, McGettrick HM, Stone PC, Jeffery HC, Savage CO, Rainger GE, Nash GB Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture. Exp. Cell Res., 2010-11-04;317(3):276-92. 2010-11-04 [PMID: 21056557] (Bioassay, Human)
• Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J. Leukoc. Biol., 2010-11-02;89(2):269-82. 2010-11-02 [PMID: 21048214] (Bioassay, Human)
• Frommhold D, Kamphues A, Hepper I, Pruenster M, Lukic IK, Socher I, Zablotskaya V, Buschmann K, Lange-Sperandio B, Schymeinsky J, Ryschich E, Poeschl J, Kupatt C, Nawroth PP, Moser M, Walzog B, Bierhaus A, Sperandio M RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood, 2010-04-20;116(5):841-9. 2010-04-20 [PMID: 20407037] (Bioassay, Human)
• Morizane S, Yamasaki K, Kabigting FD, Gallo RL Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid. J. Invest. Dermatol., 2010-01-21;130(5):1297-306. 2010-01-21 [PMID: 20090765] (Bioassay, Human)
• Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J. Immunol., 2009-12-21;184(3):1642-52. 2009-12-21 [PMID: 20026745] (Binding Assay, Human)
• Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology, 2009-12-02;129(4):536-46. 2009-12-02 [PMID: 20002784] (Bioassay, Human)
• van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin. Exp. Immunol., 2009-10-01;158(1):143-53. 2009-10-01 [PMID: 19737241] (Bioassay, Human)
• Li Z, Alam S, Wang J, Sandstrom CS, Janciauskiene S, Mahadeva R Oxidized alpha1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema. Am. J. Physiol. Lung Cell Mol. Physiol., 2009-06-12;297(2):L388-400. 2009-06-12 [PMID: 19525388] (ELISA (Standard))
• Shahrara S, Pickens SR, Dorfleutner A, Pope RM IL-17 induces monocyte migration in rheumatoid arthritis. J. Immunol., 2009-03-15;182(6):3884-91. 2009-03-15 [PMID: 19265168] (Bioassay, Human)
• Yammani RR, Long D, Loeser RF Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum., 2009-03-01;60(3):792-800. 2009-03-01 [PMID: 19248116] (Bioassay, Human)
• Mizutani K, Sud S, Pienta KJ Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts. J. Cell. Biochem., 2009-03-01;106(4):563-9. 2009-03-01 [PMID: 19170075] (Bioassay, Human)
• Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 2008-12-29;206(1):249-58. 2008-12-29 [PMID: 19114666] (Bioassay, Human)
• Bendrik C, Dabrosin C Estradiol increases IL-8 secretion of normal human breast tissue and breast cancer in vivo. J. Immunol., 2009-01-01;182(1):371-8. 2009-01-01 [PMID: 19109168] (Bioassay, Human)
• Osei-Kumah A, Smith R, Clifton VL Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Cytokine, 2008-07-17;43(2):187-93. 2008-07-17 [PMID: 18639465] (ELISA (Standard))
• Bonecchi R, Borroni EM, Anselmo A, Doni A, Savino B, Mirolo M, Fabbri M, Jala VR, Haribabu B, Mantovani A, Locati M Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood, 2008-05-14;112(3):493-503. 2008-05-14 [PMID: 18480427] (Bioassay, Human)
• Nobile C, Lind M, Miro F, Chemin K, Tourret M, Occhipinti G, Dogniaux S, Amigorena S, Hivroz C Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes. Blood, 2008-01-18;111(7):3579-90. 2008-01-18 [PMID: 18203954] (Bioassay, Human)
• Yang HT, Cohen P, Rousseau S IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell. Signal., 2007-11-07;20(2):375-80. 2007-11-07 [PMID: 18065201] (Bioassay, Human)
• Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin. Chem., 2007-11-01;53(11):2010-2. 2007-11-01 [PMID: 18030696] (ELISA (Standard))
• Siegbahn A, Johnell M, Nordin A, Aberg M, Velling T TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler. Thromb. Vasc. Biol., 2007-11-08;28(1):135-41. 2007-11-08 [PMID: 17991872] (Bioassay, Human)
• Sakaguchi M, Sonegawa H, Murata H, Kitazoe M, Futami J, Kataoka K, Yamada H, Huh NH S100A11, an dual mediator for growth regulation of human keratinocytes. Mol. Biol. Cell, 2007-10-31;19(1):78-85. 2007-10-31 [PMID: 17978094] (Bioassay, Human)
• Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA (Standard))
• Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. J. Biol. Chem., 2007-08-24;282(43):31643-55. 2007-08-24 [PMID: 17720976] (Bioassay, Human)
• Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J. Exp. Med., 2007-03-12;204(3):667-80. 2007-03-12 [PMID: 17353365] (Bioassay, Human)
• Fitzgerald DC, Meade KG, McEvoy AN, Lillis L, Murphy EP, Machugh DE, Baird AW Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells. Vet. Immunol. Immunopathol., 2007-01-09;116(1):59-68. 2007-01-09 [PMID: 17276517] (ELISA (Standard))
• Fan X, Patera AC, Pong-Kennedy A, Deno G, Gonsiorek W, Manfra DJ, Vassileva G, Zeng M, Jackson C, Sullivan L, Sharif-Rodriguez W, Opdenakker G, Van Damme J, Hedrick JA, Lundell D, Lira SA, Hipkin RW Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. J. Biol. Chem., 2006-12-29;282(16):11658-66. 2006-12-29 [PMID: 17197447] (Binding Assay, Mouse)
• Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J. Exp. Med., 2006-11-20;203(12):2763-77. 2006-11-20 [PMID: 17116732] (Bioassay, Human)
• Smith C, Damas JK, Otterdal K, ØIe E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Froland SS, Hansson GK, Aukrust P Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation. J. Am. Coll. Cardiol., 2006-09-27;48(8):1591-9. 2006-09-27 [PMID: 17045893] (Bioassay, Human)
• Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Bystrom M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect. Immun., 2006-09-18;74(12):6730-8. 2006-09-18 [PMID: 16982824] (ELISA (Standard))
• Daryadel A, Grifone RF, Simon HU, Yousefi S Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha. J. Biol. Chem., 2006-07-21;281(37):27653-61. 2006-07-21 [PMID: 16861224] (Bioassay, Human)
• Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 2006-06-16;120(2):220-31. 2006-06-16 [PMID: 16782408] (ELISA (Standard))
• Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006-05-11;126(9):2096-105. 2006-05-11 [PMID: 16691197] (Bioassay, Human)
• Bersinger NA, von Roten S, Wunder DM, Raio L, Dreher E, Mueller MD PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis. Am. J. Obstet. Gynecol., 2006-04-25;195(1):103-8. 2006-04-25 [PMID: 16635455] (ELISA (Standard))
• Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat)
• Nakayama T, Shirane J, Hieshima K, Shibano M, Watanabe M, Jin Z, Nagakubo D, Saito T, Shimomura Y, Yoshie O Novel antiviral activity of chemokines. Virology, 2006-04-17;350(2):484-92. 2006-04-17 [PMID: 16603217] (Binding Assay, Bioassay, Virus)
• Wunder DM, Mueller MD, Birkhauser MH, Bersinger NA Increased ENA-78 in the follicular fluid of patients with endometriosis. Acta Obstet Gynecol Scand, 2006-01-01;85(3):336-42. 2006-01-01 [PMID: 16553183] (ELISA (Standard))
• Ramachandran R, Morice AH, Compton SJ Proteinase-activated receptor2 agonists upregulate granulocyte colony-stimulating factor, IL-8, and VCAM-1 expression in human bronchial fibroblasts. Am. J. Respir. Cell Mol. Biol., 2006-02-23;35(1):133-41. 2006-02-23 [PMID: 16498082] (ELISA (Standard))
• Edwards MR, Johnson MW, Johnston SL Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am. J. Respir. Cell Mol. Biol., 2006-01-19;34(5):616-24. 2006-01-19 [PMID: 16424382] (ELISA (Standard))
• Trevino JG, Summy JM, Gray MJ, Nilsson MB, Lesslie DP, Baker CH, Gallick GE Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Res., 2005-08-15;65(16):7214-22. 2005-08-15 [PMID: 16103072] (In Vivo, Mouse)
• Mihara K, Smit MJ, Krajnc-Franken M, Gossen J, Rooseboom M, Dokter W Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. Eur. J. Immunol., 2005-09-01;35(9):2573-82. 2005-09-01 [PMID: 16094689] (In Vivo, Mouse)
• Kim KH, Burkhart K, Chen P, Frevert CW, Randolph-Habecker J, Hackman RC, Soloway PD, Madtes DK Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice. Am. J. Respir. Cell Mol. Biol., 2005-06-09;33(3):271-9. 2005-06-09 [PMID: 15947421] (In Vivo, Mouse)
• Holst RM, Mattsby-Baltzer I, Wennerholm UB, Hagberg H, Jacobsson B Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand, 2005-06-01;84(6):551-7. 2005-06-01 [PMID: 15901266] (ELISA (Standard))
• Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J. Immunol., 2004-12-01;173(11):6592-602. 2004-12-01 [PMID: 15557149] (Bioassay, Human)
• Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)
• Scapini P, Carletto A, Nardelli B, Calzetti F, Roschke V, Merigo F, Tamassia N, Pieropan S, Biasi D, Sbarbati A, Sozzani S, Bambara L, Cassatella MA Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases. Blood, 2004-09-09;105(2):830-7. 2004-09-09 [PMID: 15358625] (Bioassay, Human)
• Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)
• Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254]
• Traves SL, Smith SJ, Barnes PJ, Donnelly LE Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2. J. Leukoc. Biol., 2004-05-20;76(2):441-50. 2004-05-20 [PMID: 15155777] (Bioassay, Human)
• Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood, 2004-05-13;104(5):1404-10. 2004-05-13 [PMID: 15142882] (ELISA (Standard))
• Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (ELISA (Standard))
• Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O&amp;apos;Reilly RJ, Dupont B, Vyas YM Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J. Immunol., 2003-12-15;171(12):6891-9. 2003-12-15 [PMID: 14662896] (Bioassay, Human)
• Keane MP, Donnelly SC, Belperio JA, Goodman RB, Dy M, Burdick MD, Fishbein MC, Strieter RM Imbalance in the expression of CXC chemokines correlates with bronchoalveolar lavage fluid angiogenic activity and procollagen levels in acute respiratory distress syndrome. J. Immunol., 2002-12-01;169(11):6515-21. 2002-12-01 [PMID: 12444162] (ELISA (Standard))
• Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J. Immunol., 2002-11-01;169(9):5244-51. 2002-11-01 [PMID: 12391243] (ELISA (Standard))
• Banisadr G, Queraud-Lesaux F, Boutterin MC, Pelaprat D, Zalc B, Rostene W, Haour F, Parsadaniantz SM Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain. J. Neurochem., 2002-04-01;81(2):257-69. 2002-04-01 [PMID: 12064472] (Binding Assay, Rat)
• Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstadt H Expression of functional CCR and CXCR chemokine receptors in podocytes. J. Immunol., 2002-06-15;168(12):6244-52. 2002-06-15 [PMID: 12055238] (Bioassay, Human)
• Humes HD, Fissell WH, Weitzel WF, Buffington DA, Westover AJ, MacKay SM, Gutierrez JM Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells. Am. J. Kidney Dis., 2002-05-01;39(5):1078-87. 2002-05-01 [PMID: 11979353] (ELISA (Standard))
• Bottcher MF, Jenmalm MC, Bjorksten B, Garofalo RP Chemoattractant factors in breast milk from allergic and nonallergic mothers. Pediatr. Res., 2000-05-01;47(5):592-7. 2000-05-01 [PMID: 10813582] (ELISA (Standard))
• Shuster DE, Kehrli ME, Rainard P, Paape M Complement fragment C5a and inflammatory cytokines in neutrophil recruitment during intramammary infection with Escherichia coli. Infect. Immun., 1997-08-01;65(8):3286-92. 1997-08-01 [PMID: 9234788] (Bioassay, Bovine)

Bioinformatics

• Gene Symbol: CXCL8
• Uniprot:
  • P10145.1()