Recombinant Human GITR/TNFRSF18 Fc Chimera Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Binding Activity

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Recombinant Human GITR/TNFRSF18 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human (rh) GITR/TNFRSF18 Fc Chimera at 2 µg/mL (100 µL/well) can bind rhGITR Ligand with a linear range of 0.3-20 ng/mL.
Mouse myeloma cell line, NS0-derived human GITR/TNFRSF18 protein
Human GITR
(Gln26-Glu161) (Thr45Ala)
Accession # Q9Y5U5
N-terminus C-terminus
Accession #
N-terminal Sequence
No results obtained: Gln26 predicted
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
41 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
50 kDa, reducing conditions

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human GITR/TNFRSF18 Fc Chimera Protein, CF

  • Activation-inducible TNFR family receptor
  • AITR
  • AITRTNF receptor superfamily activation-inducible protein
  • CD357 antigen
  • CD357
  • GITR
  • GITR-D
  • GITRtumor necrosis factor receptor superfamily member 18
  • Glucocorticoid-induced TNFR-related protein
  • TNFRSF18
  • tumor necrosis factor receptor superfamily, member 18


GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune regulation (1, 2). Mature human GITR consists of a 137 amino acid (aa) extracellular domain (ECD) with three tandem TNFR cysteine-rich repeats, a 21 aa transmembrane segment, and a 58 aa cytoplasmic domain (3, 4). Within the ECD, human GITR shares 55% and 60% aa sequence identity with mouse and rat GITR, respectively. Alternative splicing generates an isoform with a short deletion in the cytoplasmic domain and a potentially secreted isoform that is substituted within the third TNFR repeat and lacks the transmembrane and cytoplasmic regions. GITR is expressed on CD4+CD25+ regulatory T cells (Treg) as well as on subsets of thymocytes, lymph node cells, and splenocytes (4-6), and it is upregulated on antigen-activated conventional CD4+ and CD8+ T cells (3, 4, 6, 7). GITR binding by GITR Ligand/TNFSF18 costimulates the proliferation and activation of CD4+ or CD8+ conventional T cells (3, 7-9). It also induces the proliferation of Treg (8, 10) but inhibits the ability of Treg to suppress immune responses (5, 8, 11-13). This can result in the development of autoimmunity, increased tumor cell killing by effector T cells (5, 11), and increased inflammation in arthritis, allergic asthma, and inflammatory bowel disease (10, 14). GITR is also expressed on sympathetic neurons where it enhances NGF-induced neurite outgrowth and branching (15).
  1. Clouthier, D.L. and T.H. Watts (2014) Cytokine Growth Factor Rev. 25:91.
  2. Ronchetti, S. et al. (2015) J. Immunol. Res. 2015:171520.
  3. Gurney, A.L. et al. (1999) Curr. Biol. 9:215.
  4. Kwon, B. et al. (1999) J. Biol. Chem. 274:6056.
  5. Shimizu, J. et al. (2002) Nat. Immunol. 3:135.
  6. Nocentini, G. et al. (1997) Proc. Natl. Acad. Sci. USA 94:6216.
  7. Muriglan, S.J. et al. (2004) J. Exp. Med. 200:149.
  8. Ronchetti, S. et al. (2004) Eur. J. Immunol. 34:613.
  9. Tone, M. et al. (2003) Proc. Natl. Acad. Sci. USA 100:15059.
  10. Ephrem, A. et al. (2013) Eur. J. Immunol. 43:2421.
  11. Ko, K. et al. (2005) J. Exp. Med. 202:885.
  12. Ji, H. et al. (2004) J. Immunol. 172:5823.
  13. Stephens, G.L. et al. (2004) J. Immunol. 173:5008.
  14. Patel, M. et al. (2005) Eur. J. Immunol. 35:3581.
  15. O'Keeffe, G.W. et al. (2008) Nat. Neurosci. 11:135.

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Gene Symbol TNFRSF18