GITR/TNFRSF18 Products

Description

GITR is encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]

Bioinformatics

Entrez	21936 Mouse 8784 Human
Uniprot	NM_004195 Human NP_004186 Human NP_004186.1 Human NP_683699 Human NP_683700 Human Q8C4K3 Mouse Q9Y5U5 Human
Product By Gene ID	8784
Alternate Names	Activation-inducible TNFR family receptor AITRTNF receptor superfamily activation-inducible protein CD357 antigen GITR-D GITRtumor necrosis factor receptor superfamily member 18 Glucocorticoid-induced TNFR-related protein tumor necrosis factor receptor superfamily, member 18

Research Areas for GITR/TNFRSF18

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Apoptosis