Recombinant Human FABP9/T-FABP Protein, CF

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R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Format
Carrier-Free

Order Details

Recombinant Human FABP9/T-FABP Protein, CF Summary

Details of Functionality
Bioassay data are not available.
Source
E. coli-derived human FABP9/T-FABP protein
Met1-Val132, with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Met1
Protein/Peptide Type
Innovator Recombinant Proteins
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
16 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
15 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 1 mg/mL in PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FABP9/T-FABP Protein, CF

  • FABP9
  • FABP-9
  • Fatty Acid Binding Protein 9, Testis
  • Fatty Acid-Binding Protein 9
  • Lipid-Binding Protein
  • PERF 15
  • PERF
  • PERF15
  • Testis Lipid Binding Protein
  • Testis Lipid-Binding Protein
  • Testis-Type Fatty Acid-Binding Protein
  • TFABP
  • T-FABP
  • TLBP

Background

Fatty acid binding protein-9 (FABP9; also named Testis lipid-binding protein, Testis-type fatty acid-binding protein, TLBP, T- FABP, PERF, or PERF15) is a member of a large superfamily of lipid binding proteins that are expressed in a tissue specific manner (1, 6, 7). FABP9 is one of ten cytoplasmic FABPs that are 14-15 kDa in size and range from 126-140 amino acids (aa) in length (1, 2, 3). Although all are highly conserved in their tertiary structure, there is only modest aa identity between any two members. The FABP family members are subdivided based on organ or tissue type it was originally expressed or identified; liver- (L-FABP), intestine- (I‑FABP), heart- (H-FABP), adipocyte- (A-FABP), epidermal- (E-FABP), ileal- (Il-FABP), brain- (B-FABP), myelin- (M-FABP) and testis-FABP (T-FABP) (1). Human T‑FABP, the product of the FABP9 gene, is a 132 aa cytosolic protein that shows a flattened beta -barrel structure generated by a series of antiparallel beta -strands and two alpha ‑helices (4, 8). One molecule of FABP-9 is capable of binding one long-chain fatty acid (1, 5). It is suggested that ligands first bind to the outside of the molecule, and this binding subsequently induces a conformational change in the binding protein, resulting in "internalization" of the ligand (4, 5). Human FABP-9 is 71%, 68% and 62% aa identical to mouse, rat and canine FABP-9, respectively. It also shows 26% and 28% aa identity to human L-FABP and I‑FABP, respectively.
  1. Smathers, R & Petersen, D. (2011) Human Genomics 5:170.
  2. Storch, J. & Thumser, AE. (2000) Biochim Biophys Acta. 1486:28.
  3. Zimmerman, A.W. & Veerkamp, J.H. (2007) Protein Sci. 9:2042.
  4. Bernlohr, D. et al. (1997) Ann. Rev. of Nut. 17:277.
  5. Majava,V. et al. (2010) PLoS One. 5:e10300.
  6. Zimmerman, A.W. and J.H. Veerkamp (2002) Cell. Mol. Life Sci. 59:1096.
  7. Haunerland, N.H. and F. Spener (2004) Prog. Lipid Res. 43:328.
  8. Oko, R. & Morales, C.R. (1994) Dev Biol. 166:235.

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