Recombinant Human Complement Factor H-related 5/CFHR5, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

Recombinant Human Complement Factor H-related 5/CFHR5, CF Summary

Details of Functionality
Measured by its ability to inhibit the binding of biotinylated Recombinant Human Complement Factor H-related 5/CFHR5 to immobilized Recombinant Human C‑Reactive Protein/CRP (Catalog # 1707-CR). McRae, J.L. et al. (2005) J. Immunol. 174:6250.
Source
Mouse myeloma cell line, NS0-derived human Complement Factor H-related 5/CFHR5 protein
Glu19-Glu569, with a C-terminal 10-His tag
Accession #
N-terminal Sequence
Glu19
Protein/Peptide Type
Recombinant Enzymes
Gene
CFHR5
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
64 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
73 kDa, reducing conditions
Publications
Read Publications using
3845-F5 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Complement Factor H-related 5/CFHR5, CF

  • CFHL5
  • CFHL5factor H-related protein 5
  • CFHR5
  • Complement Factor Hrelated 5
  • Complement Factor H-related 5
  • FHR5
  • FHR-5complement factor H-related protein 5
  • FHR5MGC133240
  • FLJ10549

Background

The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1 (FHL-1) and five factor H-related proteins (FHR-1 to -5) (2). Members of this family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. The genes of this family have been located in human chromosome 1q32, which is known as the regulator of complement activation (RCA) gene clusters (3). FHR-5 has been identified initially as a universal component of complement deposits (1), and detected in glomerular immune deposits (4). The pattern of deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. It is synthesized in the liver and consists of 9 SCRs. Its biological function is not understood fully. FHR-5 exhibits similar characteristics as those of factor H in heparin binding, CRP binding, and lipoprotein association (5). Weak factor I-dependent cofactor activity for C3b cleavage has also been observed (5).

  1. McRae, J. L. et al. (2001) J. Biol. Chem. 276:6747.
  2. Zipfel, P. F. et al. (2002) Biochem. Soc. Trans. 30:971.
  3. McRae, J. L. et al. (2002) Genetica. 114:157.
  4. Murphy, B. et al. (2002) Am. J. Kidney. Dis. 39:24.
  5. McRae, J. L. et al. (2005) J. Immunol. 174:6250.

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Bioinformatics

Gene Symbol CFHR5
Entrez
Uniprot