Recombinant Amphibian TGF-beta 5 Protein

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Product Details

Summary
Reactivity AmSpecies Glossary
Applications Bioactivity

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Catalog# & Formulation Size Price

Recombinant Amphibian TGF-beta 5 Protein Summary

Details of Functionality
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 0.01-0.03 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived amphibian TGF-beta 5 protein
Gly271-Ser382 & Gln274-Ser382
Accession #
N-terminal Sequence

Gly271 & Gln274

Protein/Peptide Type
Recombinant Proteins
Gene
tgfb1
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
12.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
245-B5 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions

Reconstituted at 20 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.

Notes

Triton is a registered trademark of Union Carbide Corp.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Amphibian TGF-beta 5 Protein

  • TGFbeta 5
  • TGF-beta 5

Background

TGF-beta 5 is a member of the TGF-beta family of growth factors. These proteins are stable, multifunctional factors with a wide variety of effects on the growth and differentiation of virtually all cell types. These actions on growth or differentiation may be stimulatory or inhibitory, depending on the cell type, growth conditions, state of differentiation and on the presence of other growth factors. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. The in vivo role of TGF-beta 5 is also not known, but the presence of this factor in Xenopus embryos, tadpole cells, and adult tissues suggests a role in the mediation of differentiation and development. Similar roles have been suggested for other members of the TGF-beta family. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

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Publications for TGF-beta 5 (245-B5)(1)

We have publications tested in 1 confirmed species: Xenopus.

We have publications tested in 1 application: In Vivo.


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In Vivo
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Xenopus
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Bioinformatics

Gene Symbol tgfb1
Uniprot