RBX1 Antibody (1076128) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clone: 1076128
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

RBX1 Antibody (1076128) [Alexa Fluor® 594] Summary

• Immunogen: Spodoptera frugiperda, Sf 21 (baculovirus)-derived human CUL1/RBX1 Complex
  Met1-His108
  Accession # P62877
• Specificity: Detects human RBX1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RBX1 Antibody (1076128) [Alexa Fluor® 594]

• BA554C12.1
• EC 6.3.2.-
• FLJ60363
• MGC13357
• Protein ZYP
• RBX1
• Regulator of cullins 1
• Ring Box 1
• RING box protein 1
• RING finger protein 75
• ring-box 1
• ring-box 1, E3 ubiquitin protein ligase
• RING-box protein 1
• RNF75
• RNF75MGC1481
• ROC1E3 ubiquitin-protein ligase RBX1
• ZYP Protein

Background

RBX1 is a constitutively expressed RING-box protein that interacts with cullins. The human RBX1 gene consists of 5 exons and 4 introns and encodes 108 amino acids with a molecular weight of about 14kda. It is a major component of E3 ubiquitin ligase. A characteristic feature of RBX1 structure is that it contains a RING-H2 finger domain at the carboxyl terminus.  RBX1 is overexpressed in many primary tumors and is associated with overall survival and lymph node metastasis. In humans, RBX1 has high expression in the heart, skeletal muscle, and testis with less expression in the brain, lung, kidney, and placenta.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.