RBX1 Products

Antibodies
RBX1 Antibody
RBX1 Antibody
NBP1-88742
Species: Hu, Mouse, Rat
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
RBX1 Antibody
RBX1 Antibody
H00009978-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
RBX1 Antibody
RBX1 Antibody
NBP2-20113
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Lysates
RBX1 Overexpression Lysate (N ...
RBX1 Overexpression Lysate (Native)
NBL1-15236
Applications: WB
Proteins
RBX1 Recombinant Protein
RBX1 Recombinant Protein
H00009978-P01
Species: Hu
Applications: WB, ELISA, PA
RBX1 Recombinant Protein Anti ...
RBX1 Recombinant Protein Antigen
NBP1-88742PEP
Species: Hu
Applications: AC
RNAi
RBX1 RNAi
RBX1 RNAi
H00009978-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

ROC1 is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC1 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. The RING-type zinc finger domain is essential for ubiquitin ligase activity. ROC1 probably also stimulates CDC34 autoubiquitination and promotes the neddylation of CUL1 and probably CUL2. ROC1 has a cytoplasmic and nuclear localization and is widely expressed in most tissues.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 9978
Alternate Names
  • FLJ60363
  • Protein ZYP
  • ring-box 1
  • Rbx1
  • RING-box protein 1
  • EC 6.3.2.-
  • RING finger protein 75
  • ZYP protein
  • Regulator of cullins 1
  • RING box protein 1
  • BA554C12.1
  • ROC1E3 ubiquitin-protein ligase RBX1
  • RNF75MGC1481
  • MGC13357
  • ring-box 1, E3 ubiquitin protein ligase

Research Areas for RBX1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Hypoxia
Neuroscience
Wnt Signaling Pathway
Zinc Finger

Bioinformatics Tool for RBX1

Discover related pathways, diseases and genes to RBX1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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