RBX1 Antibody (1076128) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 1076128
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

RBX1 Antibody (1076128) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human RBX1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RBX1 Antibody (1076128) [Alexa Fluor™ Plus 594]

• BA554C12.1
• EC 6.3.2.-
• FLJ60363
• MGC13357
• Protein ZYP
• RBX1
• Regulator of cullins 1
• Ring Box 1
• RING box protein 1
• RING finger protein 75
• ring-box 1
• ring-box 1, E3 ubiquitin protein ligase
• RING-box protein 1
• RNF75
• RNF75MGC1481
• ROC1E3 ubiquitin-protein ligase RBX1
• ZYP Protein

Background

RBX1 is a constitutively expressed RING-box protein that interacts with cullins. The human RBX1 gene consists of 5 exons and 4 introns and encodes 108 amino acids with a molecular weight of about 14kda. It is a major component of E3 ubiquitin ligase. A characteristic feature of RBX1 structure is that it contains a RING-H2 finger domain at the carboxyl terminus.  RBX1 is overexpressed in many primary tumors and is associated with overall survival and lymph node metastasis. In humans, RBX1 has high expression in the heart, skeletal muscle, and testis with less expression in the brain, lung, kidney, and placenta.

1. Shao J, Feng Q, Jiang W, Yang Y, Liu Z, Li L, Yang W, Zou Y. E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism. Aging (Albany NY). 2022 Jul 8;14(13):5493-5510. doi: 10.18632/aging.204163. Epub 2022 Jul 8. PMID: 35802537; PMCID: PMC9320552. 
2. Wei D, Sun Y. Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer Targets. Genes Cancer. 2010 Jul;1(7):700-7. doi: 10.1177/1947601910382776. PMID: 21103004; PMCID: PMC2983490.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.