Rat JE/MCP-1/CCL2 DuoSet ELISA, 5 Plate

• Reactivity: Rt
• Applications: ELISA
• Conjugate: Biotin

Rat JE/MCP-1/CCL2 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CCL2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat JE/MCP-1/CCL2 DuoSet ELISA, 5 Plate

• C-C motif chemokine ligand 2
• CCL2
• GDCF-2
• HC11
• HSMCR30
• MCAF
• Mcp1
• MCP-1
• SCYA2
• SMC-CF

Background

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

Publications for CCL2/JE/MCP-1 (DY3144-05)(19)

Publications using DY3144-05

• Tojo, K;Yazawa, T; A high fraction of inspired oxygen does not mitigate atelectasis-induced lung tissue hypoxia or injury in experimental acute respiratory distress syndrome Scientific reports 2025-01-14 [PMID: 39809828] (Rat)
• Bae, E;Kim, S;Sung, JH;Kim, JH;Jung, SH;Song, KS;Cho, WS; The oxidative stress-dependent pulmonary inflammation of inhalable multi-walled carbon nanotube-containing nano-concrete dust and its comparison with conventional concrete dust and DQ12 Journal of hazardous materials 2024-07-15 [PMID: 39029181] (Rat)
• Lokman, MS;Kassab, R;Salem, FAM;Elshopakey, GE;Hussein, A;Aldarmahi, AA;Theyab, A;Alzahrani, KJ;Hassan, KE;Alsharif, KF;Albrakati, A;Tayyeb, JZ;El-Khadragy, MF;Alkhateeb, MA;Al-Ghamdy, AO;Althagafi, HA;Abdel Moneim, A;El-Hennamy, RE; Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis Bioscience reports 2024-05-05 [PMID: 38699907] (Rat)
• Lin, CY;Omoscharka, E;Liu, Y;Cheng, K; Establishment of a Rat Model of Alcoholic Liver Fibrosis with Simulated Human Drinking Patterns and Low-Dose Chemical Stimulation Biomolecules 2023-08-24 [PMID: 37759693] (Rat)
• SK Tirunavall, M Kuncha, R Sistla, SB Andugulapa Targeting TGF-beta/periostin signaling by sesamol ameliorates pulmonary fibrosis and improves lung function and survival The Journal of nutritional biochemistry, 2023-03-21;0(0):109294. 2023-03-21 [PMID: 36948431] (Rat)
• T Naruse, H Otake, T Takahashi Effects of a lysophosphatidic acid receptor 1 antagonist on hypertensive renal injury in Dahl-Iwai salt-sensitive rats Oncogene, 2022-05-13;149(4):179-188. 2022-05-13 [PMID: 35717071] (Rat)
• H Gu, Y Xu, N Du, Y Yu, W Zheng, Y Du Pb Induces MCP-1 in the Choroid Plexus Biology, 2022-02-15;11(2):. 2022-02-15 [PMID: 35205174] (Rat)
• E D'Alessand, B Scaf, C Munts, A van Hunnik, CJ Trevelyan, S Verheule, HMH Spronk, NA Turner, H Ten Cate, U Schotten, FA van Nieuwe Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1 Cells, 2021-10-30;10(11):. 2021-10-30 [PMID: 34831181] (Rat)
• T Pelé, S Giraud, S Joffrion, V Ameteau, A Delwail, JM Goujon, L Macchi, T Hauet, F Dkhissi, O Benzakour Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats International Journal of Molecular Sciences, 2021-11-09;22(22):. 2021-11-09 [PMID: 34829984] (Rat)
• X Kang, L Jiang, F Lan, YY Tang, P Zhang, W Zou, YJ Chen, XQ Tang Hydrogen Sulfide Antagonizes Sleep Deprivation-induced Depression- and Anxiety-like Behaviors by Inhibiting Neuroinflammation in A Hippocampal Sirt1-dependent Manner Brain research bulletin, 2021-10-05;177(0):194-202. 2021-10-05 [PMID: 34624463] (Rat)
• Y Zhang, L Jiang, T Huang, D Lu, Y Song, L Wang, J Gao Mechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats Respiratory Research, 2021-09-21;22(1):250. 2021-09-21 [PMID: 34548087] (Rat)
• X Wang Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide?induced acute pneumonia in rats Molecular Medicine Reports, 2020-08-04;0(0):. 2020-08-04 [PMID: 32945404] (Rat)
• D Xu, S Liao, Y Lv, J Wang, L Kong NMR-based metabolomics approach reveals effects of antioxidant nutrients in sepsis-induced changes in rat liver injury J. Nutr. Biochem., 2020-06-02;85(0):108440. 2020-06-02 [PMID: 32799135] (Rat)
• L Lei, X Li, YJ Yuan, ZL Chen, JH He, JH Wu, XS Cai Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates 2,4,6-trinitrobenzenesulfonic acid-induced colitis via repressing toll-like receptor 4/nuclear factor-kappa B Kaohsiung J. Med. Sci., 2020-05-12;0(0):. 2020-05-12 [PMID: 32396274] (Rat)
• T Gulan, T Yeernuer, S Sui, N Mayinuer A Rat Model of Maternal Polycystic Ovary Syndrome Shows that Exposure to Androgens In Utero Results in Dysbiosis of the Intestinal Microbiota and Metabolic Disorders of the Newborn Rat Med. Sci. Monit., 2019-12-09;25(0):9377-9391. 2019-12-09 [PMID: 31815927] (Rat)
• M Li, H Yu, H Pan, X Zhou, Q Ruan, D Kong, Z Chu, H Li, J Huang, X Huang, A Chau, W Xie, Y Ding, P Yao Nrf2 Suppression Delays Diabetic Wound Healing Through Sustained Oxidative Stress and Inflammation Front Pharmacol, 2019-09-20;10(0):1099. 2019-09-20 [PMID: 31616304] (Rat)
• M Jerkic, C Masterson, L Ormesher, S Gagnon, S Goyal, R Rabani, G Otulakowsk, H Zhang, BP Kavanagh, JG Laffey Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis J Clin Med, 2019-06-13;8(6):. 2019-06-13 [PMID: 31200579] (Rat)
• X Huo, T Zhang, Q Meng, C Li, B You Resveratrol Effects on a Diabetic Rat Model with Coronary Heart Disease Med. Sci. Monit., 2019-01-18;25(0):540-546. 2019-01-18 [PMID: 30658350] (Rat)
• SB Won, YH Kwon Maternal Consumption of Low-Isoflavone Soy Protein Isolate Confers the Increased Predisposition to Alcoholic Liver Injury in Adult Rat Offspring Nutrients, 2018-03-10;10(3):. 2018-03-10 [PMID: 29534433] (Rat)

Bioinformatics

• Gene Symbol: CCL2