Rat IL-18 DuoSet ELISA, 5 Plate

• Reactivity: Rt
• Applications: ELISA
• Conjugate: Biotin

Rat IL-18 DuoSet ELISA, 5 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat IL-18 DuoSet ELISA, 5 Plate

• Iboctadekin
• IFN-gamma-inducing factor
• IGIF
• IGIFIL-1 gamma
• IL18
• IL-18
• IL-18MGC12320
• IL-1F4
• IL1F4iboctadekin
• IL-1g
• Interferon gamma-inducing factor
• interleukin 18 (interferon-gamma-inducing factor)
• Interleukin-1 gamma
• interleukin-18

Background

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

Publications for IL-18/IL-1F4 (DY521-05)(11)

Publications using DY521-05

• Zhou, J;Zhou, H;Zhu, J;Fang, S; Kaempferol inhibits cardiomyocyte pyroptosis via promoting O-GlcNAcylation of GSDME and improved acute myocardial infarction BMC pharmacology & toxicology 2025-04-08 [PMID: 40200275] (Rat)
• Liu, Y;Liu, B;Shi, M;Ye, T;Li, H; NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity Mediators of inflammation 2025-02-03 [PMID: 39949920] (Rat)
• Fang, L;Yu, Z;Qian, X;Fang, H;Wang, Y; LDHA exacerbates myocardial ischemia-reperfusion injury through inducing NLRP3 lactylation BMC cardiovascular disorders 2024-11-16 [PMID: 39548367] (Rat)
• Dutta, D;Liu, J;Xu, E;Xiong, H; Methamphetamine Enhancement of HIV-1 gp120-Mediated NLRP3 Inflammasome Activation and Resultant Proinflammatory Responses in Rat Microglial Cultures International Journal of Molecular Sciences 2024-03-22 [PMID: 38612400] (Rat)
• Lin, CY;Omoscharka, E;Liu, Y;Cheng, K; Establishment of a Rat Model of Alcoholic Liver Fibrosis with Simulated Human Drinking Patterns and Low-Dose Chemical Stimulation Biomolecules 2023-08-24 [PMID: 37759693] (Rat)
• J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023;9(4):e15333. 2023 [PMID: 37123969] (Rat)
• J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023-04-11;9(4):e15333. 2023-04-11 [PMID: 37123969] (Rat)
• C Liao, H Zhou, H Chen, G Cheng, S Li, F Ma, X Yang, B Xie, W Zhang DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model International immunopharmacology, 2022-10-21;113(0):109284. 2022-10-21 [PMID: 36279673] (Rat)
• S Huang, Z Hong, L Zhang, J Guo, Y Li, K Li HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by Activating TLR4/NF-kappaB Signaling Pathway Mediators of Inflammation, 2022-08-04;2022(0):1376959. 2022-08-04 [PMID: 35966335] (Rat)
• B Sun, Z Chen, Q Chi, Y Zhang, B Gao Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP) Journal of Cellular and Molecular Medicine, 2021-10-13;0(0):. 2021-10-13 [PMID: 34643045] (Rat)
• J Zhou, JS Wu, Y Yan, J Li, T Ni, W Shao, JH Mei, WZ Xiong, H Wu MiR-199a modulates autophagy and inflammation in rats with cerebral infarction via regulating mTOR expression Eur Rev Med Pharmacol Sci, 2020-06-01;24(11):6338-6345. 2020-06-01 [PMID: 32572931] (Rat)

FAQs for IL-18/IL-1F4 (DY521-05). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.