Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit, 2 Plate

Platelet caspase 1 activity and IL‐1 beta secretion in response to CLP. Caspase 1 activity (A) was measured in platelet homogenates obtained from CLP and Sham rats. IL‐1 beta concentration (B) was measured in conditioned media from CLP and Sham rat platelets via ELISA. *P < 0.05 versus Sham. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/31054188), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: Rt
• Applications: ELISA
• Conjugate: HRP

Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit, 2 Plate Summary

• Background: The Quantikine Rat IL-1 beta Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat IL-1 beta in cell culture supernates, serum, and EDTA plasma. It contains recombinant rat IL-1 beta and antibodies raised against recombinant rat IL-1 beta. This immunoassay has been shown to quantitate the recombinant rat factor accurately.
• Specificity: Natural and recombinant rat IL-1 beta
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il1b

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat IL-1 beta/IL-1F2 Quantikine ELISA Kit, 2 Plate

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

The Interleukin 1 (IL-1) family of proteins consists of the classic members IL-1 alpha , IL-1 beta , and IL-1ra, plus IL-18, IL-33, and IL-1F5-10. IL-1 alpha and IL-1 beta bind to the same cell surface receptors and share biological functions (1). IL-1 is not produced by unstimulated cells of healthy mice with the exception of skin keratinocytes, some epithelial cells, and certain cells of the central nervous system. In response to inflammatory agents, infections, or microbial endotoxins, however, a dramatic increase in the production of IL-1 by macrophages and various other cell types is observed. IL-1 beta plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. Inappropriate or prolonged production of IL-1 has been implicated in a variety of pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases (2-5).

 IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both are synthesized as 31 kDa precursors that are subsequently cleaved into mature proteins of approximately 17.5 kDa (6, 7). Cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response (2, 8). Neither IL-1 alpha nor IL-1 beta contains a typical hydrophobic signal peptide (9-11), but evidence suggests that these factors can be secreted by non-classical pathways (12, 13). A portion of unprocessed IL-1 alpha can be presented on the cell membrane and may retain biological activity (14). The precursor form of IL-1 beta , unlike the IL-1 alpha precursor, shows little or no biological activity in comparison to the processed form (13, 15). Both unprocessed and mature forms of IL-1 beta are exported from the cell. 

 IL-1 alpha and IL-1 beta exert their effects through immunoglobulin superfamily receptors that additionally bind IL-1ra. The 80 kDa transmembrane type I receptor (IL-1 RI) is expressed on T cells, fibroblasts, keratinocytes, endothelial cells, synovial lining cells, chondrocytes, and hepatocytes (16, 17). The 68 kDa transmembrane type II receptor (IL-1 RII) is expressed on B cells, neutrophils, and bone marrow cells (18). The two IL-1 receptor types show approximately 28% homology in their extracellular domains but differ significantly in that the type II receptor has a cytoplasmic domain of only 29 amino acids (aa), whereas the type I receptor has a 217 aa cytoplasmic domain. IL-1 RII does not appear to signal in response to IL-1 and may function as a decoy receptor that attenuates IL-1 function (19). The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction (20). IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 (21, 22). Soluble forms of both IL-1 RI and IL-1 RII have been detected in human plasma, synovial fluids, and the conditioned media of several human cell lines (23, 24). In addition, IL-1 binding proteins that resemble soluble IL-1 RII are encoded by vaccinia and cowpox viruses (25).

&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-1 beta/IL-1F2 (RLB00)(169)

Publications using RLB00

• Mahmoud, NM;Elshazly, SM;El-Shaarawy, F;Zaitone, SA;Aldahish, AA;Ahmed, GA;Fawzy, MS;Aloyouni, SY;Abed, SY;Saeedi, T;El-Sayed, SS; Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress Frontiers in pharmacology 2024-12-02 [PMID: 39687303] (Rat)
• Ayash, TA;Allard, MJ;Chevin, M;Sébire, G; IL-1 Blockade Mitigates Autism and Cerebral Palsy Traits in Offspring In-Utero Exposed to Group B Streptococcus Chorioamnionitis International journal of molecular sciences 2024-10-23 [PMID: 39518945] (Rat)
• Rabelo, TK;Campos, ACP;Almeida Souza, TH;Mahmud, F;Popovic, MR;Covolan, L;Betta, VC;DaCosta, L;Lipsman, N;Diwan, M;Hamani, C; Deep brain stimulation mitigates memory deficits in a rodent model of traumatic brain injury Brain stimulation 2024-10-15 [PMID: 39419474] (Rat)
• Katahira, S;Barth, M;Döpp, R;Sugimura, Y;Schmidt, V;Selig, JI;Saiki, Y;Jankowski, J;Marx, N;Jahnen-Dechent, W;Lichtenberg, A;Akhyari, P; Pioglitazone treatment mitigates cardiovascular bioprosthetic degeneration in a chronic kidney disease model Frontiers in pharmacology 2024-08-08 [PMID: 39175545] (Rat)
• Aekwattanaphol, N;Das, SC;Khadka, P;Nakpheng, T;Ali Khumaini Mudhar Bintang, M;Srichana, T; Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for combating pulmonary tuberculosis International journal of pharmaceutics 2024-08-18 [PMID: 39163929] (Rat)
• Hong, SW;Piao, L;Cho, EH;Seo, EH;Kim, SH; The Effect of Pregabalin on Microglia Differentiation in Rat with Neuropathic pain: A Preliminary Study International journal of medical sciences 2024-05-13 [PMID: 38818478] (Rat)
• Liu, X;Liu, Y;Su, X;Jiang, L;Tang, G;Wang, Y; Geranylgeranylacetone mitigates sepsis-associated intestinal injury through CHIP-dependent anti-inflammation and anti-oxidative effect International immunopharmacology 2024-05-23 [PMID: 38788444] (Rat)
• Lokman, MS;Kassab, R;Salem, FAM;Elshopakey, GE;Hussein, A;Aldarmahi, AA;Theyab, A;Alzahrani, KJ;Hassan, KE;Alsharif, KF;Albrakati, A;Tayyeb, JZ;El-Khadragy, MF;Alkhateeb, MA;Al-Ghamdy, AO;Althagafi, HA;Abdel Moneim, A;El-Hennamy, RE; Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis Bioscience reports 2024-05-05 [PMID: 38699907] (Rat)
• Zhou, W;Qu, H;Fu, XX;Xu, MM;Li, Q;Jiang, Y;Han, S; Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model Frontiers in pharmacology 2024-02-06 [PMID: 38384299] (Rat)
• Kasumi, E;Chiba, M;Kuzumaki, Y;Kuzuoka, H;Sato, N;Takahashi, B; Development and Characterization of a Cancer Cachexia Rat Model Transplanted with Cells of the Rat Lung Adenocarcinoma Cell Line Sato Lung Cancer (SLC) Biomedicines 2023-10-18 [PMID: 37893197] (Rat)
• Deng, J;Golub, LM;Lee, HM;Bhatt, HD;Johnson, F;Xu, TM;Gu, Y; A novel modified-curcumin 2.24 resolves inflammation by promoting M2 macrophage polarization Scientific reports 2023-09-19 [PMID: 37726411] (Rat)
• Ince, LM;Darling, JS;Sanchez, K;Bell, KS;Melbourne, JK;Davis, LK;Nixon, K;Gaudet, AD;Fonken, LK; Sex differences in microglia function in aged rats underlie vulnerability to cognitive decline Brain, behavior, and immunity 2023-09-12 [PMID: 37709153] (Rat)
• El Gazzar, WB;Sliem, RE;Bayoumi, H;Nasr, HE;Shabanah, M;Elalfy, A;Radwaan, SE;Gebba, MA;Mansour, HM;Badr, AM;Amer, MF;Ashour, SS;Morsi, H;Aboelkomsan, ESAF;Baioumy, B;Sayed, AEH;Farag, AA; Melatonin Alleviates Intestinal Barrier Damaging Effects Induced by Polyethylene Microplastics in Albino Rats International journal of molecular sciences 2023-09-03 [PMID: 37686424] (Rat)
• Sun, F;Xu, K;Zhou, J;Zhang, W;Duan, G;Lei, M; Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways BMC cardiovascular disorders 2023-08-18 [PMID: 37596540] (Rat)
• Kim, HR;Lee, SH;Noh, EM;Choi, B;Seo, HY;Jang, H;Kim, SY;Park, MH; Therapeutic Effect of Enzymatically Hydrolyzed Cervi Cornu Collagen NP-2007 and Potential for Application in Osteoarthritis Treatment International journal of molecular sciences 2023-07-19 [PMID: 37511425] (Rat)
• Bai, Y;Mi, W;Meng, X;Dong, B;Jiang, Y;Lu, Y;Yu, Y; Hydrogen alleviated cognitive impairment and blood‒brain barrier damage in sepsis-associated encephalopathy by regulating ABC efflux transporters in a PPAR alpha -dependent manner BMC neuroscience 2023-07-20 [PMID: 37474902] (Mouse)
• Changsan, N;Sawatdee, S;Suedee, R;Chunhachaichana, C;Srichana, T; Aqueous cannabidiol ?-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms International journal of pharmaceutics 2023-05-12 [PMID: 37182795] (Mouse)
• Zeng, W;Takashima, K;Tang, Q;Zou, X;Ojiro, R;Ozawa, S;Jin, M;Ando, Y;Yoshida, T;Shibutani, M; Natural antioxidant formula ameliorates lipopolysaccharide-induced impairment of hippocampal neurogenesis and contextual fear memory through suppression of neuroinflammation in rats Journal of chemical neuroanatomy 2023-05-05 [PMID: 37150363] (Rat)
• J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023-04-11;9(4):e15333. 2023-04-11 [PMID: 37123969] (Rat)
• J Meng, J Tian, Y Zhao, C Li, Y Yi, Y Zhang, J Han, L Wang, C Pan, S Liu, C Liu, F Wang, X Tang, D Wang, S Qin, A Liang Ameliorative effect of cheqianzi decoction on hyperuricemia and kidney injury and underlying mechanism in rats Heliyon, 2023;9(4):e15333. 2023 [PMID: 37123969] (Rat)
• T Yue, X Li, X Chen, T Zhu, W Li, B Wang, C Hang Hemoglobin Derived from Subarachnoid Hemorrhage-Induced Pyroptosis of Neural Stem Cells via ROS/NLRP3/GSDMD Pathway Oxidative Medicine and Cellular Longevity, 2023-01-16;2023(0):4383332. 2023-01-16 [PMID: 36703912] (Rat)
• J Yang, L Miao, Y Xue, X Wang Yiyi Fuzi Baijiang Powder Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats via Inhibiting the TLR4/NF-kappaB/NLRP3 Inflammasome Signaling Pathway to Repair the Intestinal Epithelial Barrier, and Modulating Intestinal Microbiota Oxidative Medicine and Cellular Longevity, 2023-01-14;2023(0):3071610. 2023-01-14 [PMID: 36691639] (Rat)
• MV Onufriev, MY Stepaniche, YV Moiseeva, MY Zhanina, OA Nedogreeva, PA Kostryukov, NA Lazareva, NV Gulyaeva A Comparative Study of Two Models of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Long-Lasting Accumulation of Corticosterone and Interleukins in the Hippocampus and Frontal Cortex in Koizumi Model Biomedicines, 2022-12-02;10(12):. 2022-12-02 [PMID: 36551875] (Rat)
• FJ Redondo-Ca, N Bejarano-R, V Baladrón, O Montenegro, LA Gómez, R Velasco, N Villasanti, S Illescas, MT Franco-Ser, I Gracia, JF Rodríguez, JR Muñoz-Rodr, JM Pérez-Orti Black Garlic and Thiosulfinate-Enriched Extracts as Adjuvants to Ceftriaxone Treatment in a Rat Peritonitis Model of Sepsis Biomedicines, 2022-12-01;10(12):. 2022-12-01 [PMID: 36551850] (Rat)
• AH Kadam, K Kandasamy, T Buss, B Cederstrom, C Yang, S Narayanapi, J Rodriguez, MD Levin, J Koziol, B Olenyuk, Z Borok, A Chrastina, JE Schnitzer Targeting caveolae to pump bispecific antibody to TGF-beta into diseased lungs enables ultra-low dose therapeutic efficacy PLoS ONE, 2022-11-22;17(11):e0276462. 2022-11-22 [PMID: 36413536] (Rat)
• S Kassem, SS Piletsky, H Yesilkaya, O Gazioglu, M Habtom, F Canfarotta, E Piletska, AC Spivey, EO Aboagye, SA Piletsky Assessing the In Vivo Biocompatibility of Molecularly Imprinted Polymer Nanoparticles Polymers, 2022-10-28;14(21):. 2022-10-28 [PMID: 36365575] (Rat)
• J Wang, Z Ye, Y Chen, X Qiao, Y Jin MicroRNA-25-5p negatively regulates TXNIP expression and relieves inflammatory responses of brain induced by lipopolysaccharide Scientific Reports, 2022-10-26;12(1):17915. 2022-10-26 [PMID: 36289253] (Rat)
• C Liao, H Zhou, H Chen, G Cheng, S Li, F Ma, X Yang, B Xie, W Zhang DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model International immunopharmacology, 2022-10-21;113(0):109284. 2022-10-21 [PMID: 36279673] (Rat)
• HJ Qin, H Li, JZ Chen, KR Zhang, XQ Zhao, JQ Qin, B Yu, J Yang Artificial nerve graft constructed by coculture of activated Schwann cells and human hair keratin for repair of peripheral nerve defects Neural regeneration research, 2023-05-01;18(5):1118-1123. 2023-05-01 [PMID: 36255001] (Rat)
• T Khamis, AE Alsemeh, DM Abdullah Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways Scientific Reports, 2022-08-27;12(1):14654. 2022-08-27 [PMID: 36030321] (Rat)
• SN Chang, M Haroon, DK Dey, SC Kang Rhabdomyolysis-induced acute kidney injury and concomitant apoptosis induction via ROS-mediated ER stress is efficaciously counteracted by epigallocatechin gallate The Journal of nutritional biochemistry, 2022-08-24;0(0):109134. 2022-08-24 [PMID: 36028100] (Rat)
• TH Tung, YC Chen, YT Lin, SY Huang N-3 PUFA Ameliorates the Gut Microbiota, Bile Acid Profiles, and Neuropsychiatric Behaviours in a Rat Model of Geriatric Depression Biomedicines, 2022-07-04;10(7):. 2022-07-04 [PMID: 35884899] (Rat)
• B Chen, G Qin, J Xiao, X Deng, A Lin, H Liu Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor Journal of Neuroinflammation, 2022-07-13;19(1):181. 2022-07-13 [PMID: 35831873] (Rat)
• Y Bai, Q Han, B Dong, H Lin, Y Jiang, X Zhang, H Chen, Y Yu PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression Brain research bulletin, 2022-03-30;184(0):56-67. 2022-03-30 [PMID: 35367313] (Mouse)
• X Gao, X Kang, H Lu, E Xue, R Chen, J Pan, J Ma Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis?fibroblast?like synoviocytes by inhibiting the NF?kappaB and MAPK signaling pathways Molecular Medicine Reports, 2022-03-24;25(5):. 2022-03-24 [PMID: 35322865] (Rat)
• MV Onufriev, YV Moiseeva, MY Zhanina, NA Lazareva, NV Gulyaeva A Comparative Study of Koizumi and Longa Methods of Intraluminal Filament Middle Cerebral Artery Occlusion in Rats: Early Corticosterone and Inflammatory Response in the Hippocampus and Frontal Cortex International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948340] (Rat)
• MG Frank, KH Nguyen, JB Ball, S Hopkins, T Kelley, MV Baratta, M Fleshner, SF Maier SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties Brain, Behavior, and Immunity, 2021-12-13;100(0):267-277. 2021-12-13 [PMID: 34915155] (Rat)
• Y Song, Z Bai, Y Zhang, J Chen, M Chen, Y Zhang, X Zhang, H Mai, B Wang, Y Lin, S Gu Protective effects of endothelial progenitor cell microvesicles on Ang�II?induced rat kidney cell injury Molecular Medicine Reports, 2021-11-05;25(1):. 2021-11-05 [PMID: 34738620] (Rat)
• YC Cheng, YM Chiu, ZK Dai, BN Wu Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats Cells, 2021-10-08;10(10):. 2021-10-08 [PMID: 34685668] (Rat)
• B Sun, Z Chen, Q Chi, Y Zhang, B Gao Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP) Journal of Cellular and Molecular Medicine, 2021-10-13;0(0):. 2021-10-13 [PMID: 34643045] (Rat)
• M Li, Z Zheng Protective effect of parecoxib sodium against ischemia reperfusion?induced intestinal injury Molecular Medicine Reports, 2021-09-09;24(5):. 2021-09-09 [PMID: 34498709] (Rat)
• ZR Du, Y Gu, XM Xie, M Zhang, GY Jiang, WF Chen GPER and IGF-1R mediate the anti-inflammatory effect of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in rats The Journal of steroid biochemistry and molecular biology, 2021-08-31;214(0):105989. 2021-08-31 [PMID: 34478828] (Rat)
• AD Shcherbits, DS Vasilev, YP Milyutina, NL Tumanova, AV Mikhel, IV Zalozniaia, AV Arutjunyan Prenatal Hyperhomocysteinemia Induces Glial Activation and Alters Neuroinflammatory Marker Expression in Infant Rat Hippocampus Cells, 2021-06-18;10(6):. 2021-06-18 [PMID: 34207057] (Rat)
• DP Wang, KY Jin, P Zhao, Q Lin, K Kang, J Hai Neuroprotective Effects of VEGF-A Nanofiber Membrane and FAAH Inhibitor URB597 Against Oxygen-Glucose Deprivation-Induced Ischemic Neuronal Injury International Journal of Nanomedicine, 2021-05-27;16(0):3661-3678. 2021-05-27 [PMID: 34093011] (Rat)
• J Sun, K Xin, C Leng, J Ge Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis BMC pulmonary medicine, 2021-06-06;21(1):191. 2021-06-06 [PMID: 34092219] (Rat)
• LL Huo, ZR Sun MiR-128-3p alleviates TNBS-induced colitis through inactivating TRAF6/NF-&amp;kappaB signaling pathway in rats The Kaohsiung journal of medical sciences, 2021-05-27;0(0):. 2021-05-27 [PMID: 34042286] (Rat)
• Y Yao, R Luo, S Xiong, C Zhang, Y Zhang Protective effects of curcumin against rat intestinal inflammation?related motility disorders Molecular Medicine Reports, 2021-03-24;23(5):. 2021-03-24 [PMID: 33760185] (Rat)
• EK Jackson, Z Mi, DG Gillespie, D Cheng, SP Tofovic Long-Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats Journal of the American Heart Association, 2021-03-08;10(6):e020088. 2021-03-08 [PMID: 33682436] (Rat)
• L Zheng, R Tang, L Shi, M Zhong, Z Zhou Vagus nerve stimulation ameliorates L-NAME-induced preeclampsia-like symptoms in rats through inhibition of the inflammatory response BMC pregnancy and childbirth, 2021-03-04;21(1):177. 2021-03-04 [PMID: 33663436] (Rat)
• H Gao, H Ma, M Gao, A Chen, S Zha, J Yan Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-&amp;kappaB signaling pathway Bioscience Reports, 2021-04-30;0(0):. 2021-04-30 [PMID: 33645622] (Mouse)
• S Sapru, S Das, M Mandal, AK Ghosh, SC Kundu Sericin-chitosan-glycosaminoglycans hydrogels incorporated with growth factors for in vitro and in vivo skin repair Carbohydrate polymers, 2021-01-29;258(0):117717. 2021-01-29 [PMID: 33593579] (Rat)
• Z Li, Z Huang, H Zhang, J Lu, Y Tian, Y Wei, Y Yang, L Bai P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-&amp;kappaB/NLRP3 Crosstalk Oxidative Medicine and Cellular Longevity, 2021-01-16;2021(0):8868361. 2021-01-16 [PMID: 33532039] (Rat)
• CR Muller, V Courelli, A Lucas, AT Williams, JB Li, F Dos Santos, CT Cuddington, SR Moses, AF Palmer, EB Kistler, P Cabrales Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin Scientific Reports, 2021-01-28;11(1):2509. 2021-01-28 [PMID: 33510204] (Rat)
• P Passaglia, F de Lima Fa, ME Batalhão, AM Stabile, LM Bendhack, J Antunes-Ro, R Lacchini, E Capellari Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia Cells, 2021-01-08;10(1):. 2021-01-08 [PMID: 33430014] (Rat)
• L Zhang, X Zhang, T Wu, X Pan, Z Wang Isoflurane reduces septic neuron injury by HO?1?mediated abatement of inflammation and apoptosis Molecular Medicine Reports, 2020-12-23;23(2):. 2020-12-23 [PMID: 33355378] (Mouse)
• JJ Alam, M Krakovsky, U Germann, A Levy Continuous administration of a p38&amp;alpha inhibitor during the subacute phase after transient ischemia-induced stroke in the rat promotes dose-dependent functional recovery accompanied by increase in brain BDNF protein level PLoS ONE, 2020-12-04;15(12):e0233073. 2020-12-04 [PMID: 33275615] (Rat)
• SJ Blaschke, S Demir, A König, JA Abraham, SU Vay, M Rabenstein, DN Olschewski, C Hoffmann, M Hoffmann, N Hersch, R Merkel, B Hoffmann, M Schroeter, GR Fink, MA Rueger Substrate Elasticity Exerts Functional Effects on Primary Microglia Front Cell Neurosci, 2020-11-05;14(0):590500. 2020-11-05 [PMID: 33250714] (Rat)
• F Yaghouby, K Jang, U Hoang, S Asgari, S Vasudevan Sex Differences in Vagus Nerve Stimulation Effects on Rat Cardiovascular and Immune Systems Front Neurosci, 2020-11-06;14(0):560668. 2020-11-06 [PMID: 33240036] (Rat)
• L Jia, K Xue, J Liu, OA Habotta, L Hu, AE Abdel Mone Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways Mediators Inflamm, 2020-09-29;2020(0):9419085. 2020-09-29 [PMID: 33061833] (Rat)
• H Li, L Fan, Y Zhang, Y Cao, X Liu SNHG16 aggravates chronic constriction injury-induced neuropathic pain in rats via binding with miR-124-3p and miR-141-3p to upregulate JAG1 Brain Res Bull, 2020-10-10;165(0):228-237. 2020-10-10 [PMID: 33049352] (Rat)
• X Wang, M Jiang, X He, B Zhang, W Peng, L Guo N?acetyl cysteine inhibits the lipopolysaccharide?induced inflammatory response in bone marrow mesenchymal stem cells by suppressing the TXNIP/NLRP3/IL?1&amp;beta signaling pathway Molecular Medicine Reports, 2020-08-13;0(0):. 2020-08-13 [PMID: 32945495] (Rat)
• M Jiang, X Wang, P Wang, W Peng, B Zhang, L Guo Inhibitor of RAGE and glucose?induced inflammation in bone marrow mesenchymal stem cells: Effect and mechanism of action Molecular Medicine Reports, 2020-08-07;0(0):. 2020-08-07 [PMID: 32945430] (Rat)
• X Wang Inhibition of HtrA2 alleviates inflammatory response and cell apoptosis in lipopolysaccharide?induced acute pneumonia in rats Molecular Medicine Reports, 2020-08-04;0(0):. 2020-08-04 [PMID: 32945404] (Rat)
• C Huang, W Zhang, A Sun, X Zhang, J Guo, R Ji, L Qiao, X Sun, D Zhao Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway Oxid Med Cell Longev, 2020-08-18;2020(0):7075836. 2020-08-18 [PMID: 32922653] (Rat)
• T Ming, M Yuan, Q Kong, Q Huang, Z Xia, X Wu Dexmedetomidine alleviates blunt chest trauma and hemorrhagic shock?resuscitation?induced acute lung injury through inhibiting the NLRP3 inflammasome Mol Med Rep, 2020-07-10;22(3):2507-2515. 2020-07-10 [PMID: 32705267] (Rat)
• ES Son, JW Park, SH Kim, HR Park, W Han, OC Kwon, JY Nam, SH Jeong, CS Lee Anti?inflammatory activity of 3,5,6,7,3&#039;,4&#039;?hexamethoxyflavone via repression of the NF?&amp;kappaB and MAPK signaling pathways in LPS?stimulated RAW264.7 cells Mol Med Rep, 2020-06-18;22(3):1985-1993. 2020-06-18 [PMID: 32705181] (Mouse)
• YN Chen, HH Sha, YW Wang, Q Zhou, P Bhuiyan, NN Li, YN Qian, HQ Dong Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats J Neuroinflammation, 2020-07-22;17(1):217. 2020-07-22 [PMID: 32698899] (Rat)
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• D Hirohama, W Kawarazaki, M Nishimoto, N Ayuzawa, T Marumo, S Shibata, T Fujita PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation Int J Mol Sci, 2020-06-22;21(12):. 2020-06-22 [PMID: 32580367] (Rat)
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Bioinformatics

• Gene Symbol: Il1b