Rat CXCL2/CINC-3 DuoSet ELISA, 15 Plate

• Reactivity: Rt
• Applications: ELISA
• Conjugate: Biotin

Rat CXCL2/CINC-3 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat CXCL2/CINC-3 DuoSet ELISA, 15 Plate

• chemokine (C-X-C motif) ligand 2
• CINC-2a
• CINC3
• CINC-3
• C-X-C Motif Chemokine 2
• CXCL2
• GRO beta
• GRO2 oncogene
• GRO2
• GROB
• Gro-beta
• Growth-regulated protein beta
• Macrophage inflammatory protein 2-alpha
• melanoma growth stimulatory activity beta
• MGSA beta
• MGSA-b
• MGSA-beta
• MIP2
• MIP-2
• MIP2A
• MIP-2a
• MIP2-alpha
• SCYB2

Background

CXCL2/GRO beta, also called MIP-2 in mouse and CINC-3 in rat, is a member of the CXC chemokine family. Human CXCL2/GRO beta is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 70% and 71% aa sequence identity with the human protein, respectively. N-terminal aa 1-4 of CXCL2/GRO beta can be post-translationally cleaved which confers enhanced hematopoietic bioactivity. CXCL2/GRO beta is produced by a variety of cell types including monocytes and macrophages at sites of inflammation and is chemotactic for granulocytes, including neutrophils.

Publications for CXCL2/GRO beta/MIP-2/CINC-3 (DY525)(10)

Publications using DY525

• Falter, J;Lohmeier, A;Eberl, P;Stoerr, EM;Koskimäki, J;Falter, L;Rossmann, J;Mederer, T;Schmidt, NO;Proescholdt, M; CXCR2-Blocking Has Context-Sensitive Effects on Rat Glioblastoma Cell Line Outgrowth (S635) in an Organotypic Rat Brain Slice Culture Depending on Microglia-Depletion (PLX5622) and Dexamethasone Treatment International journal of molecular sciences 2023-11-27 [PMID: 38069130] (Rat)
• HE Burzynski, VA Macht, JL Woodruff, JN Crawford, JM Erichsen, GG Piroli, CA Grillo, JR Fadel, LP Reagan Pyridostigmine bromide elicits progressive and chronic impairments in the cholinergic anti-inflammatory pathway in the prefrontal cortex and hippocampus of male rats Neurobiology of stress, 2022-04-15;18(0):100446. 2022-04-15 [PMID: 35573808] (Rat)
• MJ Jeong, S Jeon, HS Yu, WS Cho, S Lee, D Kang, Y Kim, YJ Kim, SY Kim Exposure to Nickel Oxide Nanoparticles Induces Acute and Chronic Inflammatory Responses in Rat Lungs and Perturbs the Lung Microbiome International Journal of Environmental Research and Public Health, 2022-01-04;19(1):. 2022-01-04 [PMID: 35010784] (Rat)
• WMT Kuwabara, CNF Yokota, R Curi, TC Alba-Loure Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils Sci Rep, 2018-12-03;8(1):17534. 2018-12-03 [PMID: 30510205] (Rat)
• D Toumpanaki, V Vassilakop, I Sigala, P Zacharatos, I Vraila, V Karavana, S Theocharis, T Vassilakop The role of Src & ERK1/2 kinases in inspiratory resistive breathing induced acute lung injury and inflammation Respir. Res., 2017-12-13;18(1):209. 2017-12-13 [PMID: 29237457] (Rat)
• Vlaar AP, Hofstra JJ, Kulik W Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model. Blood, 2010-05-17;116(8):1360-8. 2010-05-17 [PMID: 20479286] (Rat)
• Hamacher J, Stammberger U, Roux J, Kumar S, Yang G, Xiong C, Schmid RA, Fakin RM, Chakraborty T, Hossain HM, Pittet JF, Wendel A, Black SM, Lucas R The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation. Crit. Care Med., 2010-03-01;38(3):871-8. 2010-03-01 [PMID: 20081530] (Rat)
• Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J. Biol. Chem., 2007-08-31;282(44):31882-90. 2007-08-31 [PMID: 17766241] (Rat)
• Birrell MA, McCluskie K, Hardaker E, Knowles R, Belvisi MG Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model. Eur. Respir. J., 2006-09-27;28(6):1236-44. 2006-09-27 [PMID: 17005583] (Rat)
• Braun C, Hamacher J, Morel DR, Wendel A, Lucas R Dichotomal role of TNF in experimental pulmonary edema reabsorption. J. Immunol., 2005-09-01;175(5):3402-8. 2005-09-01 [PMID: 16116234] (Rat)

FAQs for CXCL2/GRO beta/MIP-2/CINC-3 (DY525). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Cxcl2