RAPGEF3 Antibody [Alexa Fluor™ Plus 594]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 594

RAPGEF3 Antibody [Alexa Fluor™ Plus 594] Summary

• Immunogen: RAPGEF3 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human RAPGEF3. The immunogen is located within amino acids 60 - 110 of RAPGEF3. Amino Acid Squence: WTPLTNSEESLDFSESLE
• Specificity: At least two isoforms of RAPGEF3 are known to exist; this antibody will detect both isoforms. RAPGEF3 antibody is predicted to not cross-react with EPAC2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RAPGEF3
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for RAPGEF3 Antibody [Alexa Fluor™ Plus 594]

• 9330170P05Rik
• bcm910
• cAMP-GEFI
• cAMP-regulated guanine nucleotide exchange factor I
• CGEF1
• EPAC 1
• EPAC
• EPAC1
• EPACRAP guanine-nucleotide-exchange factor (GEF) 3
• Exchange factor directly activated by cAMP 1
• Exchange protein directly activated by cAMP 1
• HSU79275
• MGC21410
• Rap guanine nucleotide exchange factor (GEF) 3
• rap guanine nucleotide exchange factor 3
• Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
• RAPGEF3

Background

RAPGEF3, also known as Rap guanine nucleotide exchange factor 3, is a 104 kDa 923 amino acid protein with two shorter isoforms produced by alternative splicing. The gene is necessary for rearranging actin at cell to cell junctions. RAPGEF3 is currently being studied for its involvement with leukemia, melanoma, pancreatitis, thyroiditis, carcinoma, prostatitis and neuronitis. RAPGEF3 is linked to the chemotaxis, cell adhesion, insulin secretion, and immune system pathways where it interacts with GNAI2, GNAI1, PDE3B, RAP1A and RAP1B.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RAPGEF3