QPRT Antibody (24C4) [HRP]

• Reactivity: Hu
• Applications: WB, ELISA, ICC/IF
• Clone: 24C4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: HRP

QPRT Antibody (24C4) [HRP] Summary

• Immunogen: Recombinant human QPRT (1-297aa) purified from E. coli
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: QPRT
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Alternate Names for QPRT Antibody (24C4) [HRP]

• EC 2.4.2.19
• nicotinate-nucleotide pyrophosphorylase (carboxylating)
• QAPRTase
• QPRTasenicotinate-nucleotide pyrophosphorylase [carboxylating]
• Quinolinate phosphoribosyltransferase [decarboxylating]
• quinolinate phosphoribosyltransferase

Background

QPRT encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: QPRT