PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE]

Images

 
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) and goat anti-mouse-PE on LNCaP cell line (positive, green) and ...read more
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (mass cytometry) of LNCaP cell line using anti-GCPII (GCP-05) 173Yb. Gated on singlets.
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) Alexa Fluor 488 on LNCaP cell line.
Flow Cytometry: PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] [NBP1-45056] - Surface staining (flow cytometry) of GCPII / PSMA using anti-GCPII (GCP-05) PE on LNCaP cell line.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IP
Clone
GCP-05
Clonality
Monoclonal
Host
Mouse
Conjugate
PE
Concentration
0.1 mg/ml

PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE] Summary

Immunogen
amino acids 44-750 of human GCPII
Specificity
The antibody GCP-05 recognizes extracellular domain of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
FOLH1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 6 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
  • Immunoprecipitation 1:50

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS and 0.2% (w/v) high grade BSA (protease free)
Preservative
15mM Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A purified

Notes

Store in the dark. Avoid prolonged exposure to light.

Alternate Names for PSMA/FOLH1/NAALADase I Antibody (GCP-05) [PE]

  • Cell growth-inhibiting gene 27 protein
  • cell growth-inhibiting protein 27
  • EC 3.4.17.21
  • FGCP
  • folate hydrolase (prostate-specific membrane antigen) 1
  • Folate hydrolase 1
  • FOLH1
  • FOLHNAALADase I
  • Folylpoly-gamma-glutamate carboxypeptidase
  • GCP2
  • GCPII
  • GCPIImGCP
  • glutamate carboxylase II
  • glutamate carboxypeptidase 2
  • Glutamate carboxypeptidase II
  • Membrane glutamate carboxypeptidase
  • mopsm
  • NAALAD1
  • NAALAD1N-acetylated-alpha-linked acidic dipeptidase I
  • NAALADase I
  • NAALAdase
  • N-acetylated alpha-linked acidic dipeptidase 1
  • prostate specific membrane antigen variant F
  • Prostate-specific membrane antigen
  • PSMA
  • PSMAFGCP
  • PSMPteroylpoly-gamma-glutamate carboxypeptidase

Background

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FOLH1
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