Proteinase 3/Myeloblastin/PRTN3 Antibody (684042) [mFluor Violet 500 SE]

• Reactivity: Hu
• Applications: WB
• Clone: 684042
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 500 SE

Proteinase 3/Myeloblastin/PRTN3 Antibody (684042) [mFluor Violet 500 SE] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf21-derived recombinant human Proteinase 3/Myeloblastin/PRTN3
  Ala26-Arg249
  Accession # P24158
• Specificity: Detects human Proteinase 3/Myeloblastin/PRTN3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human Granzyme B is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: PRTN3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Proteinase 3/Myeloblastin/PRTN3 Antibody (684042) [mFluor Violet 500 SE]

• ACPA
• AGP7
• AGP7PR3
• azurophil granule protein 7
• C-ANCA
• EC 3.4.21
• EC 3.4.21.76
• Leukocyte proteinase 3
• MBN
• MBT
• Myeloblastin
• Neutrophil proteinase 4
• NP4
• NP-4
• P29C-ANCA antigen
• PR-3CANCA
• Proteinase 3
• PRTN3
• serine proteinase, neutrophil
• Wegener autoantigen
• Wegener granulomatosis autoantigen

Background

Myeloblastin (PR3) is a polymorphonuclear leukocyte serine protease which degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. PR3 plays a role in neutrophil response to inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRTN3