Protein S/PROS1 Antibody (818002) [Alexa Fluor® 532]

• Reactivity: Mu
• Applications: WB
• Clone: 818002
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 532

Protein S/PROS1 Antibody (818002) [Alexa Fluor® 532] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse Protein S/PROS1
  Met1-Arg669
  Accession # Q08761
• Specificity: Detects mouse Protein S/PROS1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Protein S is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Protein S/PROS1 Antibody (818002) [Alexa Fluor® 532]

• EC 3.4.21
• PROS
• PROS1
• protein S (alpha)
• Protein S
• protein Sa
• PS21
• PS22
• PS23
• PS24
• PS25
• PSA
• vitamin K-dependent plasma protein S
• vitamin K-dependent protein S

Background

Protein S (PROS1) is a 70-75 kDa plasma glycoprotein member of the vitamin K dependent family of proteins.  It is synthesized by hepatocytes, Sertoli cells, macrophages, vascular smooth muscle cells and endothelium.  Protein S is a non-enzymatic cofactor for activated protein C and participates in the degradation of coagulation factors FVa and FVIIIa.  It also binds to Axl on smooth muscle, likely initiating mitosis.  Protein S circulates free in plasma and, unlike Protein S in human and rat, does not complex with C4BP.  Mouse Protein S precursor is 675 amino acids (aa) in length.  It contains a signal sequence (aa 1-24), a cleavable prosegment (aa 25-41) and a 634 aa mature region.  The mature molecule contains one Gla region (aa 42-87), four EGF-like domains (aa 117-283) and two laminin G-like regions (aa 299-665).  Over aa 1-169 of the mature molecule, mouse Protein S shares 80% and 88% aa identity with human and rat Protein S, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.