Prosurfactant Protein C Antibody

• Reactivity: Hu, Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.1 mg/ml

Prosurfactant Protein C Antibody Summary

• Description: Novus Biologicals Rabbit Prosurfactant Protein C Antibody (NBP3-11283) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The polyclonal antibody is raised against recombinant human Prosurfactant Protein C (AA 1-33), GST fusion.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SFTPC
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: For Immunohistochemistry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 0.2 um filtered solution in PBS, 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A purified

Alternate Names for Prosurfactant Protein C Antibody

• PSP-C
• pulmonary surfactant-associated protein C
• Pulmonary surfactant-associated proteolipid SPL(Val)
• SFTP2
• SFTP2pulmonary surfactant apoprotein-2 SP-C
• SMDP2surfactant, pulmonary-associated protein C
• SP-CSP5
• surfactant protein C

Background

The polyclonal antibody recognizes the human surfactant protein C (SP-C). There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant. SP-C is a 34-35 amino acid peptide, of 4 kD that is proteolytically processed from a 21 kD precursor protein. SP-C is initiated early in the embryogenic period of lung formation, where SP-C transcripts are detected uniformly in epithelial cells lining the primitive airways. During lung development SP-C expression is decreased in cells of the proximal conducting portion of the lung. Ultimately SP-C is expressed selectively in type II epithelial cells in the alveolus of the lung. SP-C is secreted into the airspace where it enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-C plays an important role in the spreading and stabilization of phospholipid films in the alveolus. SP-C is essential for air-breathing in mammals and is therefore largely conserved. Deficiency of SP-C and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS). The polyclonal antibody is raised against recombinant human pro-SP-C (AA 1-33), GST fusion. The polyclonal antibody is cross reactive with mouse SP-C.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SFTPC