Prokineticin R2/PROKR2 Antibody

Immunohistochemistry-Paraffin: Prokineticin 2 Antibody [NBP1-44314] - Analysis of anti-PROKR2 antibody with human thyroid.

Immunohistochemistry-Paraffin: Prokineticin 2 Antibody [NBP1-44314] - Analysis of anti-PROKR2 antibody with human brain, cerebellum.

Product Discontinued

Prokineticin R2/PROKR2 Antibody Summary

• Immunogen: Synthetic 15 amino acid peptide from N-terminal extracellular domain of human Prokineticin R2/PROKR2.
• Specificity: Human Prokineticin R2/PROKR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Primate (100%), Equine (93%), Opossum (93%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PROKR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml
• Application Notes: Proteinase K treatment is required for antigen retrieval.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoset (100%), Gorilla (87%), Canine (87%), Bat (87%), Bovine (87%), Rabbit (87%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Prokineticin R2/PROKR2 Antibody

• dJ680N4.3
• G protein-coupled receptor 73-like 1
• GPR73bG-protein coupled receptor 73-like 1
• GPR73L1
• GPR73L1Kallmann syndrome 3 (autosomal dominant)
• GPRg2
• GPRg2KAL3
• KAL3
• PKR2
• PKR2PK-R2
• Prokineticin R2
• prokineticin receptor 2
• ProkineticinR2
• PROKR2

Background

Prokineticin 2 is known to regulate many different biological functions, including neurogenesis, smooth muscle contractility, angiogenesis and circadian rhythm. In serving the latter role, prokineticin 2 functions as an output molecule from the suprachiasmatic nucleus (SCN) of the hypothalamus, that transmits behavioral rhythms, but may also function locally within the SCN to synchronize output. Prokineticin 2 expression is induced by CLOCK and BMAL1 heterodimers and light, and is inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2). Expression is reported in the SCN and among a few other discrete brain areas, including the islands of Calleja, media l preoptic area of the hypothalamus and the shell of the nucleus accumbens as well as in the testis, prostate and, at lower levels, in the small intestine.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PROKR2