Progesterone R/NR3C3 Antibody (PGR/6854R)

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Progesterone R/NR3C3 Antibody (PGR/6854R).

Formalin-fixed, paraffin-embedded horse smooth muscle stained with Progesterone R/NR3C3 Antibody (PGR/6854R).

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Progesterone R/NR3C3 Antibody (PGR/6854R).

• Reactivity: Hu, Eq
• Applications: IHC
• Clone: PGR/6854R
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

Progesterone R/NR3C3 Antibody (PGR/6854R) Summary

• Description: Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
  
  Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Recombinant fragment (around aa 1-200) of human PGR (exact sequence is proprietary) (Uniprot: P06401)
• Localization: Cytoplasm, Mitochondrion outer membrane, Nucleus
• Source: HEK293
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PGR
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 10 mM PBS with 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Progesterone R/NR3C3 Antibody (PGR/6854R)

• NR3C3
• NR3C3PRNuclear receptor subfamily 3 group C member 3
• PGR
• Progesterone R
• progesterone receptor
• ProgesteroneR

Background

The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Progesterone R/NR3C3 Antibody (NBP3-48949). (Showing 1 - 1 of 1 FAQ).

1. I am interested in getting antibodies for PR (progesterone receptor) that would work in flow cytometry. Could you recommend some choices?
   • We do not currently have any antibodies directed towards the progesterone receptor that have been validated in flow cytometry, but any of our antibodies that work in ICC should work just fine in flow as they are essentially the same application. Please see this link for our Progesterone Receptor antibodies validated in ICC.

Bioinformatics

• Gene Symbol: PGR